The Neutrophil to Lymphocyte Ratio has a High Negative Predictive Value for Pathologic Complete Response in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Eryılmaz, Melek Karakurt; Mutlu, Hasan; Salim, Derya Kivrak; Musri, Fatma Yalcin; Tural, Deniz; Çoşkun, Hasan Şenol

doi:10.7314/apjcp.2014.15.18.7737

Cited by 34 publications

(21 citation statements)

References 27 publications

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“…Studies including All BC Molecular Subtypes: the PCR rate in the function of NLR was the primary objective in seven studies [22][23][24][25][27][28][29]. In all studies (except for two without definition), PCR was defined as the complete disappearance of invasive tumors in breast and lymph nodes (patients with residual ductal carcinoma in situ were also considered to have achieved PCR: ypT0/is pN0).…”

Section: Results On Nlr and Pcrmentioning

confidence: 99%

“…(1) Patients Receiving Neo-Adjuvant Therapy Ten studies reported data on NLR as a predictive or prognostic factor in patients receiving neo-adjuvant therapy [22][23][24][25][26][27][28][29][30][31]. Among these studies, eight included patients with all molecular subtypes [22][23][24][25][26][27][28][29], one included only patients with triple negative BC (TNBC) [31] and the last one included only patients with hormone receptor-positive/HER2-negative BC [30]. The NLR cut-off for the statistical analyses was between 1.7 and 3.33, and was computed by a receiver operating characteristic (ROC) curve analysis in all studies.…”

Section: In Early Bcmentioning

confidence: 99%

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Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic Review

Corbeau

Jacot

Guiu

2020

Cancers

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Inflammatory blood markers (IBM), such as the neutrophil to lymphocyte ratio (NLR), have emerged as potential prognostic factors in various cancers, including breast cancer (BC), potentially allowing an easy, minimally invasive evaluation of a given cancer‘s prognosis and treatment outcome. We report here a systematic overview of the published data evaluating NLR as a prognostic factor or predictive factor for pathological complete response (PCR) and toxicity in early and advanced BC. A total of 45 articles were identified. NLR was found to be an independent prognostic factor for survival in most of the adjuvant treatment studies. However, no significant correlation was found between survival and NLR for early BC patients receiving neo-adjuvant chemotherapy (NACT) and advanced BC patients. Most studies failed to find a significant correlation between NLR and PCR after NACT. Finally, some data showed that IBM could be predictive of chemotherapy-related toxicity.

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Section: Results On Nlr and Pcrmentioning

confidence: 99%

Section: In Early Bcmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic Review

Corbeau

Jacot

Guiu

2020

Cancers

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“…It is associated with prognosis in various types of cancers including gastrointestinal tract cancers, hepatocellular carcinoma, non-small cell carcinoma and cervical carcinoma (Walsh SR et al, 2005;Guthrie et al, 2013;Unal et al, 2013;Eryilmaz MK et al, 2014;Kemal et al, 2014) Preoperative NLR values can be contribute clinicians as well as diagnosis and prognosis in BPBD and breast cancer which associated with inflammation. The purpose of present study was to assess the association between primary breast carcinoma and BPBD which are related with inflammatory processes.…”

mentioning

confidence: 99%

Diagnostic and Prognostic Importance of the Neutrophil Lymphocyte Ratio in Breast Cancer

Özyalvaçlı¹,

Yesil²,

Karğı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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IntroductionsBreast cancer is the most common type of cancer in women and the risk increases with age. As in other tumors the development of breast carcinoma is associated with systemic inflammation. The systemic inflammatory response can change with tumor growth, invasion, angiogenesis and metastasis. İnflammatory markers such as c reactive protein (CRP) and interleukin 6 (IL 6) are increased in breast cancer patients and a have adverse effect on survey (Balta et al., 2013).Benign proliferative breast disease (BPBD) is most common in women who are in their thirties to fifties. Various sizes of cysts, adenosis, hyperplasia with atypia and/or without atypia and apocrine metaplasia can be seen in BPBD on microscopic examination. Despite the strong association between BPBD and breast cancer development, the exact causes of BPBD are still unknown. Hormonal imbalance especially increased estrogen via to progestin is thought to play a role in development of BPBD. Breast cancer risk related with proliferative breast disease. Several studies showed that inflammation plays an important role in the development of BPBD and early breast carcinogenesis (Catsburg et al., 2014).Complete blood count and its subtype neutrophil count and neutrophil lymphocyte ratio (NLR) are an indicator of systemic inflammation (Guthrie et al., 2013). AbstractBackground: The aim of this study was to determine diagnostic and prognostic roles of the neutrophil to lymphocyte ratio (NLR) in breast cancer patients. To date, data are limited on associations of primary breast carcinoma (PBC) and benign proliferative breast disease (BPBD) with preoperative NLR values. Materials and Methods: Our study covered of 120 female patients with PBC and 50 with BPBD. Diagnostic values of NLR were estimated using sensitivity, specificity and areas under receiver operating characteristic curves (AUC). Results: NLR values were significantly higher in the PBC patients than in those with BPBD, with an AUC of 0.668 in the PBC case. The optimal cut-off for NLR was 2.96 and this was validated in the testing set, giving a sensitivity and a specificity of 79.7% and 76.2%, respectively, in PBC patients. Conclusions: Preoperative high NLR is a significant diagnostic predictor of distinction of breast cancer from BPBD and elevated NLR is also an important prognostic marker for primary invasive breast cancer.

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“…Previous research also demonstrated that NLR was correlated with chemotherapeutic response (33,42). Conversely, Eryilmaz et al (43) demonstrated no significant association between CR and NLR levels. In the present study, it was confirmed that PNC and NLR were significant predictors of chemotherapeutic response.…”

Section: Discussionmentioning

confidence: 98%

Predictive value of inflammatory indexes on the chemotherapeutic response in patients with unresectable lung cancer: A retrospective study

Sun

et al. 2018

Oncol Lett

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The Neutrophil to Lymphocyte Ratio has a High Negative Predictive Value for Pathologic Complete Response in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Cited by 34 publications

References 27 publications

Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic Review

Neutrophil to Lymphocyte Ratio as Prognostic and Predictive Factor in Breast Cancer Patients: A Systematic Review

Diagnostic and Prognostic Importance of the Neutrophil Lymphocyte Ratio in Breast Cancer

Predictive value of inflammatory indexes on the chemotherapeutic response in patients with unresectable lung cancer: A retrospective study

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