The Neutrophil to Lymphocyte Ratio is a Prognostic Biomarker of Mortality Among Patients With Acute Limb Ischaemia

Ruiz-Carmona, Carlos; Velescu, Alina; Galarza, Andrés Fernando Andrade; Calsina, Laura; Elosúa, Roberto; Clarà, Albert Benet i

doi:10.1016/j.ejvs.2020.02.031

Cited by 2 publications

(4 citation statements)

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“…As for ALI, pre-operative NLR values were independently associated with 30-day death and amputation in several retrospective studies on patients undergoing lower limb revascularization for ALI [ 139 , 140 , 142 , 143 ]. Similar results were found for longer follow-ups [ 141 , 142 , 174 ].…”

Section: The Established Role Of Neutrophils In Peripheral Artery Dis...supporting

confidence: 86%

The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives

Buso

Faggin

Rosenblatt‐Velin

et al. 2023

IJMS

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In recent years, increasing attention has been paid to the role of neutrophils in cardiovascular (CV) disease (CVD) with evidence supporting their role in the initiation, progression, and rupture of atherosclerotic plaque. Although these cells have long been considered as terminally differentiated cells with a relatively limited spectrum of action, recent research has revealed intriguing novel cellular functions, including neutrophil extracellular trap (NET) generation and inflammasome activation, which have been linked to several human diseases, including CVD. While most research to date has focused on the role of neutrophils in coronary artery and cerebrovascular diseases, much less information is available on lower limb peripheral artery disease (PAD). PAD is a widespread condition associated with great morbidity and mortality, though physician and patient awareness of the disease remains low. To date, several studies have produced some evidence on the role of certain biomarkers of neutrophil activation in this clinical setting. However, the etiopathogenetic role of neutrophils, and in particular of some of the newly discovered mechanisms, has yet to be fully elucidated. In the future, complementary assessment of neutrophil activity should improve CV risk stratification and provide personalized treatments to patients with PAD. This review aims to summarize the basic principles and recent advances in the understanding of neutrophil biology, current knowledge about the role of neutrophils in atherosclerosis, as well as available evidence on their role of PAD.

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Section: The Established Role Of Neutrophils In Peripheral Artery Dis...supporting

confidence: 86%

The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives

Buso

Faggin

Rosenblatt‐Velin

et al. 2023

IJMS

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Section: Discussionmentioning

confidence: 83%

“…A further study performed in 148 patients with advanced kidney disease who underwent percutaneous transluminal angioplasty for PAD showed that NLR ≥3.76 can significantly and independently predict allcause mortality and major amputation. 41 The association between mortality and NLR in 226 patients with PAD surgically treated was more recently confirmed in a retrospective study published by Ruiz-Carmona et al 42 These studies suggest that NLR values ranging between 5.0 and 5.25 are strongly associated with negative outcomes after several types of surgery performed for CLI or ALI. However, further prospective studies are warranted to determine the predictive role of NLR in patients undergoing different types of lower limb vascular surgery.…”

Section: Nlr Nlr As a Predictor Of Amputation Risk In Conservative Th...mentioning

confidence: 84%

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Blood Cell Count Biomarkers, Risk, and Outcomes of Ischemia-Related Lower Limb Amputations: A Systematic Review

Dettori¹,

Mangoni

Zinellu

et al. 2020

The International Journal of Lower Extremity Wounds

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Lower limb amputations due to ischemia represent an important health care and social issue. However, there are currently no specific biomarkers able to predict the risk of amputation and postamputation complications and prognosis. We conducted a systematic review of studies investigating whether blood cell count indexes of systemic inflammation are linked to the risk and the outcome of lower limb amputations due to ischemia. Overall, in 22 studies involving 8832 patients selected for review, several blood cell count indexes, particularly the neutrophil lymphocyte ratio, showed some promise in terms of predicting amputations and general outcomes of conservative and surgical treatments, as well as postamputation complications and prognosis. However, largely due to methodological limitations, further prospective studies are required to establish the clinical utility and applicability of blood cell indexes in the routine management of patients with ischemia-related lower limb amputations.

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The Neutrophil to Lymphocyte Ratio is a Prognostic Biomarker of Mortality Among Patients With Acute Limb Ischaemia

Cited by 2 publications

References 5 publications

The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives

The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives

Blood Cell Count Biomarkers, Risk, and Outcomes of Ischemia-Related Lower Limb Amputations: A Systematic Review

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