The neutrophil-lymphocyte ratio to predict poor prognosis of critical acute myocardial infarction patients

Abstract

Introduction:Inflammation is closely related to adverse outcomes of acute myocardial infarction (AMI). This study aimed to evaluate whether neutrophil-lymphocyte ratio (NLR) can predict poor prognosis of critical AMI patients. Materials and methods:We designed a retrospective cohort study and extracted AMI patients from the "Medical Information Mart for Intensive Care-III" database. The primary outcome was 1-year all-cause mortality. The secondary outcomes were 90-day and in-hospital all-cause mortalities, and acute kidney injury (AKI) incidence. The optimal cut-offs of NLR were picked by X-tile software according to the 1-year mortality and patient groups were created: low-NLR (< 4.8), high-NLR (4.8 -21.1), and very high-NLR (> 21.1). Cox and modified Poisson regression models were used to evaluate the effect of NLR on outcomes in critically AMI patients. Results: Finally, 782 critical AMI patients were enrolled in this study, and the 1-year mortality was 32% (249/782). The high-and very high-NLR groups had a higher incidence of outcomes than the low-NLR group (P < 0.05). The multivariate regression analyses found that the high-and very high-NLR groups had a higher risk of 1-year mortality (Hazard ratio (HR)

A nonlinear relationship between systemic inflammation response index and short-term mortality in patients with acute myocardial infarction: a retrospective study from MIMIC-IV

“…TDROC curves were used to compare the predictive value of the risk stratification based on ln-SIRI and the risk stratification based on optimal cutoffs of NLR ( 10 ) ( Figure 5 and Table 7 ). In the risk stratification based on ln-SIRI, for the 30-day mortality, the AUC is 0.6198, and the Max Youden is 0.2068.…”

“…AMI is a formidable global health challenge, accounting for nearly 1.8 million deaths annually and representing a staggering 20% of all mortalities in Europe ( 10 ). Given its high incidence and dire prognosis, AMI poses a grave threat to public health.…”

“…The areas under the TDROC curves were used to compare the predictive value of the risk stratification based on SIRI and the predictive value of the risk stratification based on the optimal cutoffs of NLR. The value of the optimal cutoffs of NLR is from the previous literature ( 10 ).…”

“…The areas under the TDROC curves were used to compare the predictive value of the risk stratification based on SIRI and the predictive value of the risk stratification based on the optimal cutoffs of NLR. The value of the optimal cutoffs of NLR is from the previous literature (10). All statistical analyses were carried out using the software packages R (https://www.R-project.org, The R Foundation) and Free Statistical software.…”

Red Blood Cell Distribution Width to Albumin Ratio for Predicting Type I Cardiorenal Syndrome in Patients with Acute Myocardial Infarction: A Retrospective Cohort Study

“…In a prospective study involving 2063 patients with AMI, the incidence and 23 Wang reported that the high and very high neutrophil-lymphocyte ratio groups had a higher risk of AKI incidence (RR = 1.44, 95% CI= 1.06-1.95, P = 0.018 and RR = 1.34, 95% CI= 0.87-2.07, P = 0.180) compared with low-NLR group. 24 Based on these studies, it is reasonable to infer that those inflammatory markers have the potential to predict CRS-I.…”