2000
DOI: 10.1016/s0016-5085(00)83228-x
|View full text |Cite
|
Sign up to set email alerts
|

The neutral amino acid transporter ASCT2 is overexpressed in human colorectal adenomas and carcinomas

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
47
0
2

Year Published

2004
2004
2018
2018

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 37 publications
(52 citation statements)
references
References 0 publications
3
47
0
2
Order By: Relevance
“…These amino acid transporters have important roles in anti-18 F-FACBC transport. Furthermore, it has been reported that ASCT2 expression is associated with aggressive biologic behavior in colorectal adenocarcinomas (29). Witte et al (29) showed that the survival of colorectal adenocarcinoma patients decreases with an increased percentage of ASCT2-positive cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…These amino acid transporters have important roles in anti-18 F-FACBC transport. Furthermore, it has been reported that ASCT2 expression is associated with aggressive biologic behavior in colorectal adenocarcinomas (29). Witte et al (29) showed that the survival of colorectal adenocarcinoma patients decreases with an increased percentage of ASCT2-positive cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, it has been shown that the expression of GLUT1, a transporter for glucose, is promoted in cancer cells (3,4). Expression of glutamine transporters such as ASCT2 is also facilitated (5,6), and this would support the cellular abundance of glutamine, which is consumed as a source of nitrogen and energy in tumor cells (7). The coordination of expression of highly efficient transporters for organic materials is requisite for powerful consumption of resources to ensure sustained cancer cell proliferation (8), and disruption of this system would lead to failure of tumor growth.…”
Section: Introductionmentioning
confidence: 99%
“…An increased expression of ASCT2 has also been documented in several types of primary tumors [14,23]. Experimental evidence has shown that the ASCT2 gene is expressed in and mediates most of the glutamine uptake in human hepatoma, breast carcinoma, neuroblastoma, colon carcinoma, and C6 glioma cell lines [1,2,4,5,11,12,17,20,21].…”
mentioning
confidence: 99%