The Neuropsychology of Drinking Behavior

Epstein, Alan N.

doi:10.1007/978-1-4684-4286-1_9

Cited by 4 publications

(3 citation statements)

References 211 publications

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“…This comparison also depicts cortical amygdala and lateral hypothalamus as primary forebrain regions showing increased activity to the combination of dehydration and the opportunity to ingest, because they are not activated by ingestion alone. These findings are consistent with considerable evidence for a hypothalamic integrative role in drinking (e.g., Epstein, 1983) and with recent suggestions for modulation of brain stem ingestive response systems by the reticular neuropil surrounding oral motor nuclei (Travers & Norgren, 1983).…”

Section: Resultssupporting

confidence: 91%

“…In any case, the response to dehydration is consistent with the activation of a number of brain regions believed to be involved in both physiological and behavioral regulation of fluid balance (Epstein, 1983). These include the magnocellular hypothalamic areas that were distinctly activated to cellular dehydration (paraventricular and supraoptic nuclei) as well as the preoptic periventricular, preoptic suprachiasmatic, and arcuate nuclei that were activated by cellular dehydration and showed trends toward activation to extracellular dehydration.…”

Section: Dehydration Receptor and Effector Systemsupporting

confidence: 59%

“…Experiment 2: Regional Metabolic Changes Related to Cellular Dehydration and to Ingestive Responding in Cellularly Dehydrated Rat Pups A fundamental characteristic of behavioral regulatory systems is that a change in internal state alters behavior in a manner consistent with reestablishing homeostasis. For the fluid balance regulatory systems, considerable progress has been made in the last two decades in defining the two major characteristics of fluid balance, volume of the cellular and extracellular fluid compartments, that are regulated (see Epstein, 1982;Fitzsimons, 1979) and in describing the forebrain receptor systems that detect changes in the state of each of these compartments (Epstein, 1983). As well, the effects of dehydration have been studied with DG (Gross, Kadekaro, Sokoloff, Holcomb, & Saavedra, 1985;Kadekaro, Gross, & Sokoloff, 1986;Nicolaidis, Le Poncin-Lafitte, Danguir, Grosdemouge, & Rapin, 1981;Schwartz et al, 1979;Sutherland, Martin, McQueen, & Fink, 1983).…”

mentioning

confidence: 99%

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Neural systems for early independent ingestion: Regional metabolic changes during ingestive responding and dehydration.

Hall¹

1989

Behavioral Neuroscience

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The ingestive behavior of young rodents, studied independently of the mother and suckling, provides a system for the developmental analysis of the neurobiology of feeding and drinking. In these experiments regional neural metabolic activity, as assessed by semiquantitative deoxyglucose (DG) autoradiography, was related to dehydration and ingestive behavior in 6-day-old rat pups. During simple ingestive responding, changes in relative DG uptake, representative of changes in neural metabolic activity, occurred primarily in hindbrain sensory and motor nuclei. Producing cellular dehydration resulted in activity changes primarily in the basal forebrain. When pups were dehydrated and allowed to ingest during the DG-uptake period, activity changes were seen in both the hindbrain and forebrain areas that responded to ingestion or dehydration alone as well as in regions that were not affected by either manipulation alone. These latter changes, which result from an interaction of behavioral and physiological stimuli, call attention to areas that may subserve motivational aspects of behavior. Extracellular dehydration was found to produce fewer and different forebrain responses in neural metabolic activity. During ingestion, the only effects of extracellular dehydration that overlapped with those of cellular dehydration appeared in circumventricular hypothalamic regions and brain stem motor nuclei. Thus, there appeared to be only a limited final common pathway for these two types of dehydration-induced drinking. Taken together, these findings in infant rats depict distributed neural systems subserving ingestion and responding to state change. They provide a starting point early in ontogeny for the developmental analysis of neural substrates of ingestive systems.

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Section: Resultssupporting

confidence: 91%

Section: Dehydration Receptor and Effector Systemsupporting

confidence: 59%