Separate controls for conditioned cephalic phases of acid secretion and drinking in the rat

The interaction of meal-related, rhythmic and homeostatic mechanisms and the generation of thirst and drinking

“…First, food elicits a pre-absorptive histamine release which may provide a pre-homeostatic activation of the renin-angiotensin system (14). There may be additional pre-homeostatic activation of the latter system via anticipatory conditioned responses (19). Further activation of the ANG II system may occur later as a result of hypovolemia as a consequence of sequestration of extracellular fluid in the gastrointestinal tract.…”