The neuroprotective potential of phenolic-enriched fractions from four Juniperus species found in Portugal

Tavares, Lucélia; McDougall, Gordon J.; Fortalezas, Sofia; Stewart, Derek; Ferreira, Ricardo B.; Santos, Cláudia N.

doi:10.1016/j.foodchem.2012.05.023

Cited by 32 publications

(26 citation statements)

References 77 publications

(98 reference statements)

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“…All these biflavonoids were already recognized in Juniperus spp. as well as in the related species of the Cupressaceae family, [18][53] [54] while simple flavonoids, reported as constituents in accessions belonging to other populations of J. turbinata, [55] [56] were not recognized in the present study.…”

Section: Analysis Of the Ethanolic Extractcontrasting

confidence: 61%

Bioactive Constituents ofJuniperus turbinataGuss. from La Maddalena Archipelago

Venditti

Maggi

Quassinti

et al. 2018

Chemistry & Biodiversity

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A comprehensive phytochemical study of Juniperus turbinata (Cupressaceae) collected from La Maddalena Archipelago (Sardinia, Italy) is reported. Both the essential oil and the ethanolic extract obtained from the aerial parts were analyzed. The essential oil appears to belong to a new chemotype compared to other Mediterranean juniper accessions, as it was favored by geographic isolation of the isles. It showed a low content of monoterpene hydrocarbons and α-terpineol, ent-manoyl oxide, 1,10-di-epi-cubenol as the major constituents. The ethanolic fraction contained mainly diterpenoids. Among these, 15-formyloxyimbricatolic acid (7) is a new natural product since it has hitherto been obtained only by synthetic route. The phenolic fraction contained biflavonoids: cupressuflavone (9), followed by minor amounts of amentoflavone (10) and hinokiflavone (11). The essential oil and six purified compounds (1 - 4, 8 and 9) were assessed for biological activities, namely antioxidant (assessed by DPPH , ABTS and FRAP methods) and cytotoxic effects towards selected human tumor cell lines (MDA-MB 231, A375 and HCT116 cells). Compound 3 exhibited higher radical scavenging activity against ABTS radical than the reference Trolox. Noteworthy, compound 8 showed powerful effects towards tumor cell lines, with IC values in the range of 0.060 - 0.201 μm, which make it a promising anticancer drug candidate.

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Section: Analysis Of the Ethanolic Extractcontrasting

confidence: 61%

Bioactive Constituents ofJuniperus turbinataGuss. from La Maddalena Archipelago

Venditti

Maggi

Quassinti

et al. 2018

Chemistry & Biodiversity

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“…Table 1 shows that the TPC values was significantly higher in hops (23.11 ± 0.03 mg GAE/g dw) as compared to juniper berries (9.08 ± 0.01 mg GAE/g dw; p < 0.05). In the present study, it was found that hops and juniper berries had lower TPC values compared with the previously reported studies, which could be due to the fact that researchers applied ethanol extraction with high concentrations [18] or employed a freeze-drying step before extraction [10]. Regarding the TFC, the juniper (2.25 ± 0.01 mg QE/g dw) contains more flavonoids as compared to hops (1.37 ± 0.01 mg QE/g dw).…”

Section: Polyphenol Estimation (Tpc Tfc and Ttc)contrasting

confidence: 60%

LC-ESI-QTOF/MS Characterization of Phenolic Compounds from Medicinal Plants (Hops and Juniper Berries) and Their Antioxidant Activity

Tang

Dunshea

Suleria

2019

Foods

122

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Hops (Humulus lupulus L.) and juniper berries (Juniperus communis L.) are two important medicinal plants widely used in the food, beverage, and pharmaceutical industries due to their strong antioxidant capacity, which is attributed to the presence of polyphenols. The present study is conducted to comprehensively characterize polyphenols from hops and juniper berries using liquid chromatography coupled with electrospray-ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF/MS) to assess their antioxidant capacity. For polyphenol estimation, total phenolic content, flavonoids and tannins were measured, while for antioxidant capacity, three different antioxidant assays including the 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant assay, the 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cation decolorization assay and the ferric reducing-antioxidant power (FRAP) assay were used. Hops presented the higher phenolic content (23.11 ± 0.03 mg/g dw) which corresponded to its strong antioxidant activity as compared to the juniper berries. Using LC-ESI-QTOF/MS, a total of 148 phenolic compounds were tentatively identified in juniper and hops, among which phenolic acids (including hydroxybenzoic acids, hydroxycinnamic acids and hydroxyphenylpropanoic acids) and flavonoids (mainly anthocyanins, flavones, flavonols, and isoflavonoids) were the main polyphenols, which may contribute to their antioxidant capacity. Furthermore, the HPLC quantitative analysis showed that both samples had a high concentration of phenolic acids and flavonoids. In the HPLC quantification, the predominant phenolic acids in hops and juniper berries were chlorogenic acid (16.48 ± 0.03 mg/g dw) and protocatechuic acid (11.46 ± 0.03 mg/g dw), respectively. The obtained results highlight the importance of hops and juniper berries as a rich source of functional ingredients in different food, beverage, and pharmaceutical industries.

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“…In fact, this extract was more active than the phenolic-enriched fractions obtained from other Juniperus species found in Portugal, none of which achieves 50% of inhibition at 200 µg/mL [16].…”

Section: Resultsmentioning

confidence: 75%

Anti-acetylcholinesterasic, antioxidant and antibacterial activities of Juniperus brevifolia extracts

Oliveira¹,

Medeiros²,

Rosa³

et al. 2015

Integr Pharm Toxicol Gentoxicol

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Juniperus brevifolia (Seub.) Antoine (Cupressaceae) is an endemic conifer of the Azores, a habitat isolated from the continental masses which may significantly influence the biosynthesis of bioactive compounds with unique features. In this context, the toxicity, antibacterial, antioxidant (DPPH) and anti-acetylcholinesterasic (anti-AChE) activities of the methanol and acetone extracts of J. brevifolia wood and bark were evaluated for the first time. In the brine-shrimp assay all the extracts showed low toxicity, with the concentration causing 50% mortality (LC 50 ) higher than 2.03 mg/mL. The acetone extract of the bark proved to be the most active against Bacillus cereus, B. subtilis and Micrococcus luteus, while the wood acetone extract showed activity only against B. cereus. No activity was observed against Gram (-) bacteria Escherichia coli and Enterobacter cloacae. The acetone extract of bark was the most active showing the higher antioxidant (EC 50 =7.0 µg/mL) and antiAChE activities (IC 50 =193 µg/mL), near to the reference compounds, quercetin (EC 50 =3.2 µg/mL) and ursolic acid (IC 50 =190 µg/mL), respectively. The present study demonstrates the great potential of the acetone bark extract of J. brevifolia as a source of new non-toxic natural bioactive compounds as antioxidant and antiacetylcholinesterasic drugs.

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The neuroprotective potential of phenolic-enriched fractions from four Juniperus species found in Portugal

Cited by 32 publications

References 77 publications

Bioactive Constituents ofJuniperus turbinataGuss. from La Maddalena Archipelago

Bioactive Constituents ofJuniperus turbinataGuss. from La Maddalena Archipelago

LC-ESI-QTOF/MS Characterization of Phenolic Compounds from Medicinal Plants (Hops and Juniper Berries) and Their Antioxidant Activity

Anti-acetylcholinesterasic, antioxidant and antibacterial activities of Juniperus brevifolia extracts

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