The neuroprotective effect of mesenchymal stem cells in colistin-induced neurotoxicity

Gergin, Özlem Öz; Gergin, I S; Pehlivan, Sibel Seçkin; Mat, Ozge Cengiz; Turan, Işıl Tuğçe; Bayram, Adnan; Gönen, Zeynep Burçin; Korkmaz, Şeyda; Biçer, Cihangir; Yildiz, Karamehmet; Yay, Arzu

doi:10.1080/15376516.2022.2090303

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…After applying antibiotic therapy, haematological and biochemical indices reached the physiological norm on the 6 th day, which, in addition to the metabolism restoration, indicates the absence of toxic effects of the drugs in the recommended doses and form. That is important because of described nephrotoxic (Heybeli et al, 2019;Rosas Espinoza et al, 2021;Eronmosele et al, 2021;Mirjalili et al, 2022) and neurotoxic (Wadia & Tran 2014;Ajiboye, 2018;Öz Gergin et al, 2022) actions of colistin.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the drug Kolidev 8M (powder for oral use) for the treatment of bacterial infections in decorative birds and European fallow deer

Sachuk,

Gutyj,

Velesyk

et al. 2022

TAVM

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Clinical tests of the commercial veterinary drug Kolidev 8M (powder for oral use) manufactured by «DEVIE» LLC (Ukraine) were conducted for the treatment of bacterial infections in 3-month-old pheasants, 30-day-old peacocks and young European fallow deer (2-3 months old). Obtained data were compared with the efficacy of the analogous drug Kolin 5. The effectiveness of the drugs was determined by the indicators of preservation, morbidity, and blood clinical and biochemical parameters. Clinical studies of the drug Kolidev 8M were carried out at the Hunting Farm «Bars», Kostopil district and the aviary of the personal peasant farm in the Rivne district. Using recommended doses of the drug Kolidev 8M according to the scheme proposed by the manufacturer ensured the preservation of pheasants at the level of 85.7%, but 100.0% of European peacocks and fallow deer survived. Kolidev 8M did not cause hemo-, immuno-and nephrotoxicity effects; on the contrary, it helped restore immune reactivity to physiological levels and eliminate signs of endotoxicosis in their bodies. Based on the results of our research, it was established that the veterinary drug Kolidev 8M (powder for oral use) has a bactericidal effect on gram-negative microorganisms Escherichia coli, Enterobacter spp., Pasteurella multocida and Salmonella enteritidis, which cause damage to the digestive and respiratory systems of pheasants, peacocks and European fallow deer, and does not cause resistance in bacteria.

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