Prevention of colistin-induced neurotoxicity: a narrative review of preclinical data

Soroudi, Setareh; Mousavi, Ghazal; Jafari, Fatemeh; Elyasi, Sepideh

doi:10.1007/s00210-023-02884-w

Cited by 4 publications

(1 citation statement)

References 78 publications

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“…Salidroside has the ability to directly reshape the gut microbiota ( Shi et al, 2022 ) and also indirectly influence them through reducing inflammation ( Liu et al, 2023 ), enhancing gut and mucus layer integrity ( Wang et al, 2021 ), promoting appropriate immune responses ( Yang et al, 2024 ), and increasing antimicrobial peptide production ( Soroudi et al, 2024 ). However, there is currently a lack of in vitro studies investigating whether and how salidroside selectively alters bacterial function or competitiveness.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Effects of salidroside on atherosclerosis: potential contribution of gut microbiota

Fei,

Hou,

Jia

2024

Front. Pharmacol.

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Graphical AbstractThis review seeks to offer a comprehensive look at how salidroside impacts gut microbiota and its potential therapeutic role in treating atherosclerosis. (A) Salidroside has been shown to have a positive impact on atherosclerosis by promoting the growth of beneficial bacteria and decreasing the levels of harmful bacteria in the body. (B) Salidroside has been shown to enhance the integrity and function of the intestinal mucosal barrier through its ability to suppress NF-κB and p38 MAPK signaling pathways, modulate the NF-κB/MAPK/JAK-STAT3 signaling pathways and increase the expression of antimicrobial peptides HD-5 and HD-6. (C) Salidroside can reduce TMAO production through reducing the abundance of Firmicutes and Proteobacteria. (D) Salidroside can improve the expression of SCFAs, through increasing the abundance of some special bacteria. (E) Salidroside can reduce LPS-induced inflammation, which is associated with the inhibition of the ROS-mediated PI3K/AKT/mTOR signaling pathway, the downregulation of exosome miR-199a-5p, and the attenuation of the Notch-Hes signaling pathway. (F) Salidroside can inhibit NLRP3-associated gut-coronary axis, including TLR4/MyD88/NF-κB/NLRP3 signaling pathway, AMPK/NF-κB/NLRP3 signaling pathway, and P2X7/NF-κB/NLRP3 signaling pathway.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Effects of salidroside on atherosclerosis: potential contribution of gut microbiota

Fei,

Hou,

Jia

2024

Front. Pharmacol.

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Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria

YURISALDI SALEH,

Yogi Saputra

2024

F1000Res

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Introduction Mitochondria are cell organelles that function as the cell’s main power plant, producing ATP, the main energy molecule in cells. Mitochondria play an important role in the context of neuroprotection, and mitochondrial function has been implicated in various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS). Recent research in the field of neuroprotection has focused on the development of therapies that target mitochondria. Natural ingredients have long been used in traditional medicine and show potential as neuroprotective agents. Methods In this work, a literature review methodology is employed to gather data from the Scopus database using the keywords natural agents, herb*, neuroprotective, and mitochondria. The data were analyzed using Biblioshiny and VOSviewer software to produce visualizations and bibliometric maps. We conducted quantitative and qualitative analyses. Results The research trend found are documents by year, most global cited document, most relevant sources, A factorial map illustrating the leading contributors of papers, documents by author, documents by country or territory, documents by subject area, network visualization, overlay visualization of scopus database using vosviewer, density visualization, thematic map, thematic evolution, cluster analysis, qualitative analysis, and word cloud. Conclusions Natural Agent Neurotropik is a natural substance that influences the brain’s nervous system and peripheral nervous system, enhancing cognition, mood, and brain function. Derived from herbs, spices, and herbal products, it has advantages over other natural agents in energy production, brain biogenesis, and neuroprotection.

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Polymyxin B neurotoxicity as manifestation of a serious life-threatening adverse reaction: clinical case

Sytov,

Epifanova,

Yukhina

et al. 2024

jour

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The aim of this work is to describe a clinical case of a serious life-threatening adverse reaction in the form of neurotoxicity (convulsions, apnea requiring mechanical ventilation) to the polymyxin B drug, and also to remind that manifestations of neurotoxicity can be extremely varied and nonspecific, and do not occur after every administration, can be delayed, require vigilance and careful monitoring both from the attending physicians and from anesthesiologistsresuscitators, neurologists, ophthalmologists, etc.A 62-year-old female patient diagnosed with stage IIIB T4G3N0M0 pleomorphic soft tissue sarcoma of the right thigh, condition after combination treatment, developed infection and necrosis of the postoperative wound (recto-abdominal flap). According to the results of a microbiological study and an antibiogram, the patient received polymyxin B as part of combination antibacterial therapy. On days 4, 5, 6, 7 of polymyxin administration, the patient experienced the following symptoms in various combinations: weakness, numbness of the face, paresthesia, paresis of the limbs, partial convulsions, respiratory depression, and apnea.After establishing a connection between neurologicalsymptoms and intravenous administration of polymyxin B (the total score on the Naranjo scale was 6 points, the degree of reliability of the “adverse reaction–drug” relationship was probable) and drug withdrawal, manifestations of neurotoxicity completely disappeared and did not reoccur. The patient was discharged in satisfactory condition.In a patient with symptoms of damage to the nervous system, it is necessary to conduct multiple differential diagnostic search to exclude stroke, epilepsy, encephalitis, hereditary and acquired neurodegenerative diseases, as well as side effects of medications. At the slightest suspicion of the likelihood of an adverse reaction to polymyxin B/colistimethate sodium, the Naranjo algorithm must be used to establish a cause-and-effect relationship between the adverse reaction and the drug.

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Prevention of colistin-induced neurotoxicity: a narrative review of preclinical data

Cited by 4 publications

References 78 publications

Effects of salidroside on atherosclerosis: potential contribution of gut microbiota

Effects of salidroside on atherosclerosis: potential contribution of gut microbiota

Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria

Polymyxin B neurotoxicity as manifestation of a serious life-threatening adverse reaction: clinical case

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