The Neurological Spectrum for Acetazolamide Pharmacotherapy: from Basic Science to Clinical Applications

Cimolai, Nevio

doi:10.1007/s42399-021-01067-z

Cited by 5 publications

(2 citation statements)

References 263 publications

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“…Moreover, heart failure patients developing blood alkalosis and urine acidosis have been associated with increased diuretic resistance [40]. These conditions could be mitigated Original Article by acetazolamide since it acts in promoting tubular bicarbonate excretion and absorption of chloride ions into blood stream [41]. Congestion treatment with acetazolamide should be carried out by careful monitoring on the serum potassium concentration for possible fast appearance of hypokalemia (≤10 days) [22].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Duta,

Zulfa,

Alina

et al. 2024

Narra X

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Acetazolamide, one of the carbonic anhydrase inhibitors, has been known to improve the efficacy of diuretic therapy in patients with in congestion heart failure. The aim this study was to investigate the effectiveness of acetazolamide when combined with loop diuretics in ameliorating diuresis and natriuresis in congestive heart failure using systematic review and meta-analysis. Randomized controlled trials (RCTs) and cohort studies were searched on PubMed, Scopus, and Embase on March 7, 2023, by using combinations of ‘acetazolamide’, ‘heart failure’ and along with their respective synonyms. The protocol had been registered on PROSPERO (CRD42023409864). The studies must investigate the effect of oral acetazolamide as the add-on to loop diuretic therapy to be included. Successful decongestion, natriuresis, and diuresis were set as the primary outcomes. The quality of the included studies was assessed using the Cochrane risk-of-bias tool for RCTs and Newcastle Ottawa Scale for observational studies. We identified 1176 titles in the initial search, and further reduced to five studies (three RCTs and two cohort studies) after in-depth screening. A total of 625 patients were recruited in the included studies published from 2015 to 2022. Results from meta-analysis revealed that acetazolamide and loop diuretics combination therapy ameliorated natriuresis (n=4; standardized means difference (SMD)=0.65; 95%CI: 0.07–1.24; p=0.03) and diuresis (n=2; SMD=0.29; 95%CI: 0.12–0.46; p=0.0009) when compared to loop diuretics alone. Acetazolamide and loop diuretics combinatorial therapy is efficacious in alleviating congestion in heart failure patients.

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Section: Discussionmentioning

confidence: 99%

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Duta,

Zulfa,

Alina

et al. 2024

Narra X

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“…After oral use, absorption of AZA is entirely actualized in gastrointestinal tract (14). AZA is nearly 95% bound to plasma proteins (15). The drug does not undergo metabolic changes in the body and is excreted by kidney in the urine within 24 hours (16).…”

Section: Introductionmentioning

confidence: 99%

Surface Plasmon Resonance Binding Study on the Interaction of Acetazolamide and Bovine Serum Albumin

TÜRKOĞLU,

AYDIN

2023

Clinical and Experimental Health Sciences

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Objective: Serum albumins are major plasma proteins in systemic blood circulation and act as transport proteins for endogenous and exogenous compounds such as drugs. In pharmaceutical applications, it is essential to characterize how drugs bind to serum albumin in the evaluation of drug candidates. Surface plasmon resonance (SPR) is fast, real-time, label-free optical based detection technique that offers the monitoring of molecular interactions, analyzing binding reactions and determining the affinity constants with real-time and high sensitivity. Acetazolamide (AZA) is used in the treatment of epilepsy and glaucoma. Methods: To determine the binding kinetics of AZA-Bovine serum albumin (BSA) interaction, (i) SPR gold sensor surface was functionalized, (ii) amine coupling procedure was applied to activate the surface group and BSA was immobilized on functionalized sensor surface, (iii) the concentration series of AZA (10, 25, 50, 75, 100, 150, 200 and 250 µM) was injected to SPR system and (iv) kinetic values were measured using the software of SPR system. Results: 5 mM MUA was coated for surface functionalization. 250 µg/mL BSA as ligand, 30 µL/min flow rate, 1X PBS buffer (pH 7.4) and 10 mM acetate buffer (pH 5.2) as running and coupling buffers, respectively, were performed for SPR binding study. According to result, equilibrium constant (KD) of AZA-BSA was determined as 67.72 µM. Conclusion: In this study, we investigated the AZA-BSA binding interaction using SPR system based on Kretchmann configuration. The study designed with fast, label-free and real-time approach will provide valuable knowledge for pharmaceutical and clinical applications.

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Lupane acetates in small molecule drug hybrids: Probing their inhibitory activity for carbonic anhydrase II

Denner,

Heise,

Zacharias

et al. 2024

European Journal of Medicinal Chemistry Reports

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The Neurological Spectrum for Acetazolamide Pharmacotherapy: from Basic Science to Clinical Applications

Cited by 5 publications

References 263 publications

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Efficacy of acetazolamide and loop diuretics combinatorial therapy in congestive heart failure: A meta-analysis

Surface Plasmon Resonance Binding Study on the Interaction of Acetazolamide and Bovine Serum Albumin

Lupane acetates in small molecule drug hybrids: Probing their inhibitory activity for carbonic anhydrase II

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