Surface Plasmon Resonance Binding Study on the Interaction of Acetazolamide and Bovine Serum Albumin
Emir Alper TÜRKOĞLU,
Fatma Gülruy AYDIN
Abstract:Objective: Serum albumins are major plasma proteins in systemic blood circulation and act as transport proteins for endogenous and exogenous compounds such as drugs. In pharmaceutical applications, it is essential to characterize how drugs bind to serum albumin in the evaluation of drug candidates. Surface plasmon resonance (SPR) is fast, real-time, label-free optical based detection technique that offers the monitoring of molecular interactions, analyzing binding reactions and determining the affinity constan… Show more
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