The neurological organization of micturition

Seth, Jai; Panicker, Jalesh N.; Fowler, Clare J.

doi:10.1016/b978-0-444-53491-0.00010-9

Cited by 17 publications

(9 citation statements)

References 35 publications

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“…Direct muscle stimulation 6 , stimulation of peripheral nerves 7 , or rhizotomy 8 to restore bladder function all have limitations. Most of these interventions fail to restore the complex, orchestrated sequence of muscle contraction and relaxation that normal, voluntary micturition requires 9 .…”

Section: Introductionmentioning

confidence: 99%

A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder

Niu

Bennett

Keller

et al. 2018

Sci Rep

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Patients with chronic spinal cord injury (SCI) cannot urinate at will and must empty the bladder by self-catheterization. We tested the hypothesis that non-invasive, transcutaneous magnetic spinal cord stimulation (TMSCS) would improve bladder function in individuals with SCI. Five individuals with American Spinal Injury Association Impairment Scale A/B, chronic SCI and detrusor sphincter dyssynergia enrolled in this prospective, interventional study. After a two-week assessment to determine effective stimulation characteristics, each patient received sixteen weekly TMSCS treatments and then received “sham” weekly stimulation for six weeks while bladder function was monitored. Bladder function improved in all five subjects, but only during and after repeated weekly sessions of 1 Hz TMSCS. All subjects achieved volitional urination. The volume of urine produced voluntarily increased from 0 cc/day to 1120 cc/day (p = 0.03); self-catheterization frequency decreased from 6.6/day to 2.4/day (p = 0.04); the capacity of the bladder increased from 244 ml to 404 ml (p = 0.02); and the average quality of life ranking increased significantly (p = 0.007). Volitional bladder function was re-enabled in five individuals with SCI following intermittent, non-invasive TMSCS. We conclude that neuromodulation of spinal micturition circuitry by TMSCS may be used to ameliorate bladder function.

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Section: Introductionmentioning

confidence: 99%

A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder

Niu

Bennett

Keller

et al. 2018

Sci Rep

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“…Therefore, centrally acting drugs may be necessary for proper management of voiding dysfunction [ 22 ]. Moreover, decision about switching from storage to voiding is dependent on social context and is strongly affected by mood [ 23 ]. In turn, voiding may affect mood and behavior, in particular in cases of dysfunction [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice

et al. 2015

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Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components. It involves the coordination of autonomic and neuromuscular activity at the brainstem level, under the executive control of the prefrontal cortex. We tested the hypothesis that administration of molecules acting as reuptake inhibitors of serotonin, noradrenaline or both may exert a strong effect on the control of urine release, in a mouse model of overactive bladder. Mice were injected with cyclophosphamide (40 mg/kg), to increase micturition acts. Mice were then given one of four molecules: the serotonin reuptake inhibitor imipramine, its metabolite desipramine that acts on noradrenaline reuptake, the serotonin and noradrenaline reuptake inhibitor duloxetine or its active metabolite 4-hydroxy-duloxetine. Cyclophosphamide increased urine release without inducing overt toxicity or inflammation, except for increase in urothelium thickness. All the antidepressants were able to decrease the cyclophosphamide effects, as apparent from longer latency to the first micturition act, decreased number of urine spots and volume of released urine. These results suggest that serotonin and noradrenaline reuptake inhibitors exert a strong and effective modulatory effect on the control of urine release and prompt to additional studies on their central effects on brain areas involved in the social and behavioral control of micturition.

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“…This excitatory mechanism is completed by bladder afferent nerves that are connected to the sacral spinal cord interneurons. This interneuron synapse involves preganglionic efferent parasympathetic nerves [ 7 ]. Once bladder contraction is initiated, the bladder–urethral reflex is activated by relaxing the smooth muscle of the proximal urethra to open the outlet.…”

Section: Bladder Function Studymentioning

confidence: 99%

Review of Animal Models to Study Urinary Bladder Function

Shen

Chen

et al. 2021

Biology

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The urinary bladder (UB) serves as a storage and elimination organ for urine. UB dysfunction can cause multiple symptoms of failure to store urine or empty the bladder, e.g., incontinence, frequent urination, and urinary retention. Treatment of these symptoms requires knowledge on bladder function, which involves physiology, pathology, and even psychology. There is no ideal animal model for the study of UB function to understand and treat associated disorders, as the complexity in humans differs from that of other species. However, several animal models are available to study a variety of other bladder disorders. Such models include animals from rodents to nonhuman primates, such as mice, rats, rabbits, felines, canines, pigs, and mini pigs. For incontinence, vaginal distention might mimic birth trauma and can be measured based on leak point pressure. Using peripheral and central models, inflammation, bladder outlet obstruction, and genetic models facilitated the study of overactive bladder. However, the larger the animal model, the more difficult the study is, due to the associated animal ethics issues, laboratory facility, and budget. This review aims at facilitating adapted animal models to study bladder function according to facility, priority, and disease.

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The neurological organization of micturition

Cited by 17 publications

References 35 publications

A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder

A Proof-of-Concept Study of Transcutaneous Magnetic Spinal Cord Stimulation for Neurogenic Bladder

Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice

Review of Animal Models to Study Urinary Bladder Function

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