The neuroendocrine system of Ciona intestinalis Type A, a deuterostome invertebrate and the closest relative of vertebrates

Satake, Honoo; Sasakura, Yasunori

doi:10.1016/j.mce.2023.112122

Molecular and Cellular Endocrinology

2024

DOI: 10.1016/j.mce.2023.112122

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The neuroendocrine system of Ciona intestinalis Type A, a deuterostome invertebrate and the closest relative of vertebrates

Honoo Satake,

Yasunori Sasakura

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2024

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Cited by 2 publications

References 135 publications

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Hormonal regulation and disruption in invertebrates – An historical perspective and recent findings

Sommer Vinagre,

Lange,

Cardoso

2024

Molecular and Cellular Endocrinology

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Hormonal regulation and disruption in invertebrates – An historical perspective and recent findings

Sommer Vinagre,

Lange,

Cardoso

2024

Molecular and Cellular Endocrinology

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A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells

Rees,

Kirk,

Gattoni

et al. 2024

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Vertebrate calcitonin-producing cells (C-cells) are neuroendocrine cells that secrete the small peptide hormone calcitonin in response to elevated blood calcium levels. Whereas mouse C-cells reside within the thyroid gland and derive from pharyngeal endoderm, avian C-cells are located within ultimobranchial glands and have been reported to derive from the neural crest. We use a comparative cell lineage tracing approach in a range of vertebrate model systems to resolve the ancestral embryonic origin of vertebrate C-cells. We find, contrary to previous studies, that chick C-cells derive from pharyngeal endoderm, with neural crest-derived cells instead contributing to connective tissue intimately associated with C-cells in the ultimobranchial gland. This endodermal origin of C-cells is conserved in a ray-finned bony fish (zebrafish) and a cartilaginous fish (the little skate, Leucoraja erinacea). Furthermore, we discover putative C-cell homologs within the endodermally-derived pharyngeal epithelium of the ascidian Ciona intestinalis and the amphioxus Branchiostoma lanceolatum, two invertebrate chordates that lack neural crest cells. Our findings point to a conserved endodermal origin of C-cells across vertebrates and to a pre-vertebrate origin of this cell type along the chordate stem.

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The neuroendocrine system of Ciona intestinalis Type A, a deuterostome invertebrate and the closest relative of vertebrates

Cited by 2 publications

References 135 publications

Hormonal regulation and disruption in invertebrates – An historical perspective and recent findings

Hormonal regulation and disruption in invertebrates – An historical perspective and recent findings

A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells

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