A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells
Jenaid M. Rees,
Katie Kirk,
Giacomo Gattoni
et al.
Abstract:Vertebrate calcitonin-producing cells (C-cells) are neuroendocrine cells that secrete the small peptide hormone calcitonin in response to elevated blood calcium levels. Whereas mouse C-cells reside within the thyroid gland and derive from pharyngeal endoderm, avian C-cells are located within ultimobranchial glands and have been reported to derive from the neural crest. We use a comparative cell lineage tracing approach in a range of vertebrate model systems to resolve the ancestral embryonic origin of vertebra… Show more
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