The neurobiology of attention deficit/hyperactivity disorder

Curatolo, Paolo; Paloscia, Claudio; D’Agati, Elisa; Moavero, Romina; Pasini, Augusto

doi:10.1016/j.ejpn.2008.06.003

Cited by 113 publications

(91 citation statements)

References 75 publications

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“…Neuropsychological studies have reported that children with ADHD have alterations in cerebral regions and circuits related to control of both cardinal symptoms (attention, hyperactivity and impulsivity) and appropriate executive functioning, emphasizing structures and pathways associated with prefrontal regions, parietal lobe, basal ganglia and cerebellum 25,26 compromising the proper functioning of planning, problem solving, strategy changes, working memory, inhibition of distraction factors as well as inappropriate behaviors and thoughts 27 .…”

Section: Resultsmentioning

confidence: 99%

Processamento auditivo temporal em crianças com transtorno do déficit de atenção com hiperatividade (TDAH)

2015

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OBJETIVO:comparar os achados da avaliação comportamental do processamento auditivo temporal em crianças com e sem Transtorno do Déficit de Atenção com Hiperatividade.MÉTODOS:participaram desse estudo 30 crianças na faixa etária de 8 a 12 anos, sendo 15 do grupo controle e 15 do grupo pesquisa, com limiares audiométricos dentro dos padrões de normalidade. Como procedimentos foram realizados os testes temporais de padrão de frequência e de duração.RESULTADOS:na comparação entre o grupo controle e grupo pesquisa em ambos os testes - padrão de frequência e padrão de duração foram verificadas diferenças significantes entre os grupos, sendo que o grupo pesquisa apresentou resultados alterados em sua maioria, enquanto que todas as crianças do grupo controle apresentaram resultados normais. Foi possível observar ainda que todas as crianças de ambos os grupos tiveram resultados inferiores para o Padrão de Duração quando comparado aos resultados do Padrão de Frequência e.CONCLUSÃO:a avaliação comportamental do processamento auditivo temporal de crianças com e sem Transtorno do Déficit de Atenção com Hiperatividade, mostrou que os sujeitos com Transtorno do Déficit de Atenção com Hiperatividade apresentaram alterações, enquanto que o grupo sem Transtorno do Déficit de Atenção com Hiperatividade resultados normais em ambos os testes. O presente estudo possibilitou um maior conhecimento da via auditiva central das crianças com e sem Transtorno do Déficit de Atenção com Hiperatividade, porém, outros estudos ainda se fazem necessários, principalmente na literatura nacional, a fim de se conhecer melhor o funcionamento do processamento auditivo dessas populações.

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Section: Resultsmentioning

confidence: 99%

Processamento auditivo temporal em crianças com transtorno do déficit de atenção com hiperatividade (TDAH)

2015

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“…Functional MRI (fMRI) studies have similarly demonstrated abnormal activation in these areas, including the prefrontal cortex, anterior cingulate gyrus and thalamus (Durston, 2003;Rubia et al, 2011). Gross anatomic studies have demonstrated a lower total brain volume in children with ADHD (Curatolo et al, 2009;Makris et al, 2009;Tripp, 2009). Additionally, decreased size of the right frontal lobe (RFL), corpus callosum, striatum and cerebellum have been observed in children and adolescents with ADHD (Curatolo et al, 2009;Makris et al, 2009;Tripp, 2009).…”

Section: Neurobiology Of Adhdmentioning

confidence: 99%

“…Gross anatomic studies have demonstrated a lower total brain volume in children with ADHD (Curatolo et al, 2009;Makris et al, 2009;Tripp, 2009). Additionally, decreased size of the right frontal lobe (RFL), corpus callosum, striatum and cerebellum have been observed in children and adolescents with ADHD (Curatolo et al, 2009;Makris et al, 2009;Tripp, 2009). The areas found to be different in ADHD are those which support emotion and higher brain functions including executive function and attention (Makris et al, 2009).…”

Section: Neurobiology Of Adhdmentioning

confidence: 99%

“…The areas found to be different in ADHD are those which support emotion and higher brain functions including executive function and attention (Makris et al, 2009). Abnormalities observed in the cerebrum and cerebellum have been found to persist with advancing age, whereas, abnormalities in the caudate normalize with age (Curatolo et al, 2009;Konrad & Eickhoff, 2010).…”

Section: Neurobiology Of Adhdmentioning

confidence: 99%

“…ADHD is associated with catecholamine dysregulation, specifically related to dopamine and norepinephrine (Curatolo et al, 2009;Faraone, 1998Faraone, , 2005Gonon, 2009;Makris et al, 2009;Rosa-Neto et al, 2005;Swanson, 2000;Tripp, 2009). The dysregulation of dopamine in ADHD has been the focus of much inquiry.…”

Section: Neurobiology Of Adhdmentioning

confidence: 99%

See 2 more Smart Citations

ADHD and Sleep Problems in Children

Hastings¹,

Felt²

2012

Current Directions in ADHD and Its Treatment

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A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder

et al. 2009

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Scientific Abstract Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to “plane of section artifacts” may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI’s were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism, Asperger syndrome, and typically-developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the high functioning autism group was significantly reduced compared to typically-developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders.

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The neurobiology of attention deficit/hyperactivity disorder

Cited by 113 publications

References 75 publications

Processamento auditivo temporal em crianças com transtorno do déficit de atenção com hiperatividade (TDAH)

Processamento auditivo temporal em crianças com transtorno do déficit de atenção com hiperatividade (TDAH)

ADHD and Sleep Problems in Children

A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder

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