The neurobiology of abstinence-induced reward-seeking in males and females

Alonso-Caraballo, Yanaira; Guha, Suman K.; Chartoff, Elena H.

doi:10.1016/j.pbb.2020.173088

Cited by 10 publications

(10 citation statements)

References 73 publications

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“…Previous targeted region-by-region analyses in rats have identified several brain regions that are activated during incubation of food and drug craving during abstinence (1, 3, 21, 28, 29).…”

Section: Discussionmentioning

confidence: 99%

“…Brain-wide patterns of increased neural activation following incubation of food seeking during abstinence Previous targeted region-by-region analyses in rats have identified several brain regions that are activated during incubation of food and drug craving during abstinence (1,3,21,28,29).…”

Section: Discussionmentioning

confidence: 99%

“…We analyzed behavioral and whole-brain Fos data using IBM SPSS Statistics (version 28) and GraphPad Prism (version 9.3). For the behavioral and whole brain analysis, alpha (significance) level was set at 0.05, two-tailed.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Fos, Arc, Zif) expression serves as a proxy for strongly activated neurons, and quantification of Fos-positive (Fos+) cells is routinely used to identify changes in neural activation patterns after exposure to different unconditioned and conditioned stimuli (23)(24)(25)(26)(27). Previous activity-mapping studies of incubation of drug and food craving have identified several brain regions (Supplementary Table S1) relevant to (1) relapse (increased Fos expression during relapse tests vs. home cage controls), and/or (2) incubation (higher Fos expression during late abstinence test vs. early abstinence test) (1,3,5,28,29). These studies used targeted one-by-one regional quantification of Fos+ cell counts in thin sectioned tissue 4 samples and focused on changes in specific pre-determined brain areas.…”

Section: Introductionmentioning

confidence: 99%

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Incubation of palatable food craving is associated with brain-wide neuronal activation in mice

Madangopal

Szelenyi

Nguyen

et al. 2022

Preprint

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Studies using rodent models have shown that relapse to drug or food seeking increases progressively during abstinence, a phenomenon termed "incubation of craving". Mechanistic studies of incubation of craving have focused on specific neurobiological targets within pre-selected brain areas. Recent methodological advances in whole-brain immunohistochemistry, clearing, and imaging now enable unbiased brain-wide cellular resolution mapping of regions and circuits engaged during learned behaviors. However, these whole brain imaging approaches were developed for mouse brains while incubation of drug craving has primarily been studied in rats and incubation of food craving has not been demonstrated in mice. Here, we established a mouse model of incubation of palatable food craving and examined food reward seeking after 1, 15, and 60 abstinence days. We then used the neuronal activity marker Fos with intact brain mapping procedures to identify corresponding patterns of brain-wide activation. Relapse to food seeking was significantly higher after 60 abstinence days than after 1 or 15 days. Using unbiased ClearMap analysis, we identified increased activation of multiple brain regions, particularly corticostriatal structures, following 60, but not 15 abstinence days. We used orthogonal SMART2 analysis to confirm these findings within corticostriatal and thalamocortical subvolumes and applied expert-guided registration to investigate subdivision and layer-specific activation patterns. Overall, we (1) identified novel brain-wide activity patterns during incubation of food seeking using complementary analytical approaches, and (2) provide a single-cell resolution whole-brain atlas that can be used to identify functional networks and global architecture underlying incubation of food craving.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incubation of palatable food craving is associated with brain-wide neuronal activation in mice

Madangopal

Szelenyi

Nguyen

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…While negative affect is certainly pertinent to a majority of relapse situations given increased stress vulnerability in addictive disorders in general, stress is not a necessary requirement for cravings. Some cravings relapses are thought to occur in the spirit of reward-seeking ( 66 , 74 , 75 ). In individuals with OUD, for instance, prevalence of non-substance addictive behaviors such as binge eating, hypersexual behavior, excessive video gaming, and gambling is up to 47% and is heavily linked to impulsivity ( 76 , 77 ).…”

Section: Brain Imaging For Mental Health and Its Relation To Technolo...mentioning

confidence: 99%

Turning data into better mental health: Past, present, and future

Moukaddam

Sano

Salas

et al. 2022

Front. Digit. Health

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In this mini-review, we discuss the fundamentals of using technology in mental health diagnosis and tracking. We highlight those principles using two clinical concepts: (1) cravings and relapse in the context of addictive disorders and (2) anhedonia in the context of depression. This manuscript is useful for both clinicians wanting to understand the scope of technology use in psychiatry and for computer scientists and engineers wishing to assess psychiatric frameworks useful for diagnosis and treatment. The increase in smartphone ownership and internet connectivity, as well as the accelerated development of wearable devices, have made the observation and analysis of human behavior patterns possible. This has, in turn, paved the way to understand mental health conditions better. These technologies have immense potential in facilitating the diagnosis and tracking of mental health conditions; they also allow the implementation of existing behavioral treatments in new contexts (e.g., remotely, online, and in rural/underserved areas), and the possibility to develop new treatments based on new understanding of behavior patterns. The path to understand how to best use technology in mental health includes the need to match interdisciplinary frameworks from engineering/computer sciences and psychiatry. Thus, we start our review by introducing bio-behavioral sensing, the types of information available, and what behavioral patterns they may reflect and be related to in psychiatric diagnostic frameworks. This information is linked to the use of functional imaging, highlighting how imaging modalities can be considered “ground truth” for mental health/psychiatric dimensions, given the heterogeneity of clinical presentations, and the difficulty of determining what symptom corresponds to what disease. We then discuss how mental health/psychiatric dimensions overlap, yet differ from, psychiatric diagnoses. Using two clinical examples, we highlight the potential agreement areas in assessment/management of anhedonia and cravings. These two dimensions were chosen because of their link to two very prevalent diseases worldwide: depression and addiction. Anhedonia is a core symptom of depression, which is one of the leading causes of disability worldwide. Cravings, the urge to use a substance or perform an action (e.g., shopping, internet), is the leading step before relapse. Lastly, through the manuscript, we discuss potential mental health dimensions.

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Research progress of the paraventricular thalamus in the regulation of sleep–wake and emotional behaviors

Liu

2022

Ibrain

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The paraventricular thalamus (PVT) is a major component of the midline structure of the thalamus. It is one of the nonspecific nuclei of the thalamus, which plays a great role in the regulation of cortical arousal. PVT, an important node in the central nervous system, sends widespread outputs to many brain regions and also accepts plentiful inputs from many brain regions to modulate diverse functions, including sleep–wake state, attention, memory, and pain. Recently, with the increasing prevalence of sleep disorders and mood disorders, people pay great attention to PVT, which was implicated in arousal and emotional behaviors. Therefore, the main purpose of this review is to illustrate the characteristic of PVT to provide a reference for future research.

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The neurobiology of abstinence-induced reward-seeking in males and females

Cited by 10 publications

References 73 publications

Incubation of palatable food craving is associated with brain-wide neuronal activation in mice

Incubation of palatable food craving is associated with brain-wide neuronal activation in mice

Turning data into better mental health: Past, present, and future

Research progress of the paraventricular thalamus in the regulation of sleep–wake and emotional behaviors

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