The Neuro-Immuno-Cutaneous-Endocrine Network: Relationship of Mind and Skin

OʼSullivan, Richard; Lipper, Graeme; Lerner, Ethan A.

doi:10.1001/archderm.134.11.1431

Cited by 90 publications

(84 citation statements)

References 52 publications

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“…Although PS-induced functional abnormalities (23,43,44) are often attributed to psychoneuroimmune abnormalities, PS-induced stimulation of endogenous GC production, which compromises both epidermal lipid synthesis and LB production, accounts for epidermal dysfunction (32)(33)(34). Because PS increases systemic GC levels and systemic administration of both the CRF inhibitor antalarmin and the GCr antagonist RU-486 completely normalize function, HPA-derived GCs are likely important mediators of the effects of PS on epidermal function.…”

Section: Discussionmentioning

confidence: 99%

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Åberg

Radek

Choi³

et al. 2007

J. Clin. Invest.

204

181

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The skin is the first line of defense against microbial infection, and psychological stress (PS) has been shown to have adverse effects on cutaneous barrier function. Here we show that PS increased the severity of group A Streptococcus pyogenes (GAS) cutaneous skin infection in mice; this was accompanied by increased production of endogenous glucocorticoids (GCs), which inhibited epidermal lipid synthesis and decreased lamellar body (LB) secretion. LBs encapsulate antimicrobial peptides (AMPs), and PS or systemic or topical GC administration downregulated epidermal expression of murine AMPs cathelin-related AMP and β-defensin 3. Pharmacological blockade of the stress hormone corticotrophin-releasing factor or of peripheral GC action, as well as topical administration of physiologic lipids, normalized epidermal AMP levels and delivery to LBs and decreased the severity of GAS infection during PS. Our results show that PS decreases the levels of 2 key AMPs in the epidermis and their delivery into LBs and that this is attributable to increased endogenous GC production. These data suggest that GC blockade and/or topical lipid administration could normalize cutaneous antimicrobial defense during PS or GC increase. We believe this to be the first mechanistic link between PS and increased susceptibility to infection by microbial pathogens.

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Section: Discussionmentioning

confidence: 99%

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Åberg

Radek

Choi³

et al. 2007

J. Clin. Invest.

204

181

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“…In 1998 the neuro-immuno-cutaneous-endocrine model was suggested to explain the mind and body connection (O Sullivan et al 1998). That model explains how many inflammatory dermatoses, such as psoriasis, are triggered or exacerbated by stress factors, including psychological stress and social environment.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Prevalence of Mental Disorders in Psoriasis: The Relevance of Psychiatric Assessment in Dermatology

et al. 2017

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“…Cytokines are secreted by virtually every nucleated cell type, and usually inducible, in response to injurious and inflammatory stimuli (Oppenheim 2001). Importantly, cytokines provide a link between various systems, providing molecular clues for physiological balance and homeostasis (O'Sullivan et al 1998). Modulation of cytokines secretion offers novel approaches in the treatment and management of a variety of disease conditions.…”

Section: Introductionmentioning

confidence: 99%

Modulation of intracellular expression of IFNγ and IL-2 in culture of splenic T lymphocytes by some flavonoid glycosides ofAlchornea floribunda

Okoye

Odimegwu

Nworu

et al. 2016

Pharmaceutical Biology

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Context Alchornea floribunda Mü ll. Arg. (Euphorbiaceae) leaves are widely used in ethnomedicine for the management of rheumatism, arthritis and toothache. Objective In this study, flavonoid glycosides isolated from Alchornea floribunda were screened for their effect on the intracellular expression of interferon-gamma (IFNg) and interleukin-2 (IL-2) type-1 cytokines. Materials and methods Chromatographic purification of the ethyl acetate fraction of the methanol leaf extract led to the isolation of seven flavonoid glycosides (1-7). Their structures were elucidated by 1D and 2D nuclear magnetic resonance and mass spectrometry. Splenocytes were treated with graded concentrations of the compounds (6.25-25 mg/mL) and incubated for 24 h. Thereafter, their effect on the expression of IFNg and IL-2 by CD4 + and CD8 + T-lymphocytes was evaluated using intracellular cytokine staining and FACS analysis. Results Compounds 1-7 (6.25-25 mg/mL) caused the up-regulation of activated CD8 + (57.85-72.45% versus 57.85% for untreated control) and, to a lesser extent, activated CD4 + (3.21-7.21% versus 2.75% for the untreated control) T-lymphocytes that were both largely interferon-gammareleasing in treated mouse T lymphocytes relative to untreated control. FACS data analysis showed that stimulation with all the compounds increased the proportion of CD8 + /IFNg + and CD4 +

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The Neuro-Immuno-Cutaneous-Endocrine Network: Relationship of Mind and Skin

Cited by 90 publications

References 52 publications

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Analysis of the Prevalence of Mental Disorders in Psoriasis: The Relevance of Psychiatric Assessment in Dermatology

Modulation of intracellular expression of IFNγ and IL-2 in culture of splenic T lymphocytes by some flavonoid glycosides ofAlchornea floribunda

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