Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Åberg, K. Magnus; Radek, Katherine A.; Choi, Eung Ho; Kim, Dong Kun; Demerjian, Marianne; Hupe, Melanie; Kerbleski, Joseph F; Gallo, Richard L.; Ganz, Tomas; Mauro, Theodora M.; Feingold, Kenneth R.; Elias, Peter M.

doi:10.1172/jci31726

Cited by 198 publications

(190 citation statements)

References 83 publications

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“…By day 7 following wounding, 85.4% of restraint-stress mice had bacterial counts predictive of infection, compared to 27.4% of controls 32 . In accord with these data, other researchers have also found that stress impairs the skin's barrier function, resulting in increased severity of cutaneous infections in mice 33 .…”

Section: Stress and Wound Healingsupporting

confidence: 69%

Omega-3 Fatty Acids and Stress-Induced Immune Dysregulation: Implications for Wound Healing

Kiecolt‐Glaser¹,

Glaser²,

Christian³

2016

Military Medicine

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Stress-related immune alterations can be consequential for health; they can enhance susceptibility to infectious agents and influence the severity of infectious disease, diminish the strength of immune responses to vaccines, reactivate latent viruses, and slow wound healing. Furthermore, stressful events and negative emotions promote systemic proinflammatory cytokine production while reducing beneficial local production of proinflammatory cytokines at the wound site that are important for wound healing. Dietary omega-3 and omega-6 polyunsaturated fatty acids (PUFA) also influence systemic inflammation; high proportions of omega-6 to omega-3 boost inflammation, while omega-3 has anti-inflammatory properties. Additionally, the limited evidence thus far suggests that omega-3 PUFA may enhance local inflammatory responses at wound sites. Moreover, an individual's dietary proportion of omega-3 to omega-6 may influence the magnitude of inflammatory responses to stressful events. Thus, wound healing and surgery provide exemplars of how stress and depression can interact with the diet to influence important clinical outcomes.

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Section: Stress and Wound Healingsupporting

confidence: 69%

Omega-3 Fatty Acids and Stress-Induced Immune Dysregulation: Implications for Wound Healing

Kiecolt‐Glaser¹,

Glaser²,

Christian³

2016

Military Medicine

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“…In addition, acute cold stress was shown to induce a significant release of -defensin in the jejunum in this study, supporting the possibility that stress might affect this protective pathway in the gut, as have been shown in the skin. 110 Furthermore, we have also found that cold stress evoked a differential gender-determined increase in human intestinal macromolecular permeability. 111 This enhanced permeability could lead to excessive uptake of luminal antigens and bacterial products that may initiate an inflammatory response in the mucosa.…”

Section: Permeabilitymentioning

confidence: 64%

Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Rodiño-Janeiro¹,

Alonso-Cotoner²,

Pigrau³

et al. 2015

J Neurogastroenterol Motil

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The interface between the intestinal lumen and the mucosa is the location where the majority of ingested immunogenic particles face the scrutiny of the vast gastrointestinal immune system. Upon regular physiological conditions, the intestinal microflora and the epithelial barrier are well prepared to process daily a huge amount of food-derived antigens and non-immunogenic particles. Similarly, they are ready to prevent environmental toxins and microbial antigens to penetrate further and interact with the mucosal-associated immune system. These functions promote the development of proper immune responses and oral tolerance and prevent disease and inflammation. Brain-gut axis structures participate in the processing and execution of response signals to external and internal stimuli. The brain-gut axis integrates local and distant regulatory networks and supersystems that serve key housekeeping physiological functions including the balanced functioning of the intestinal barrier. Disturbance of the brain-gut axis may induce intestinal barrier dysfunction, increasing the risk of uncontrolled immunological reactions, which may indeed trigger transient mucosal inflammation and gut disease. There is a large body of evidence indicating that stress, through the brain-gut axis, may cause intestinal barrier dysfunction, mainly via the systemic and peripheral release of corticotropin-releasing factor. In this review, we describe the role of stress and corticotropin-releasing factor in the regulation of gastrointestinal permeability, and discuss the link to both health and pathological conditions. (J Neurogastroenterol Motil 2015;21:33-50)

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“…Psychological stress decreased epidermal cell proliferation, adversely effected differentiation and decreased the size and density of corneodesmosomes, all of which negatively impact barrier function (47). Stress decreased antimicrobial peptides in the epidermis (animal model), an effect which resulted in more severe skin infections (48).…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Epidermal Innate Immunity in Premature and Full-Term Infants

et al. 2010

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ABSTRACT:Epidermal innate immunity is a complex process involving a balance of pro-and anti-inflammatory cytokines, structural proteins, and specific antigen presenting cells occurring against a background of neuroendocrine modulators such as cortisol. In this study, a multiplex array system was used to simultaneously determine multiple molecular factors critical for development of epidermal innate immune function from the skin surface of premature and term infants, healthy adults, and vernix caseosa. Samples were analyzed for Keratin 1,10,11, Keratin 6, involucrin, albumin, fibronectin and cortisol, and cytokines IL-1, TNF␣, IL-6, IL-8, MCP1, IP10, IFN␥, and IL-1 receptor antagonist. Keratin 1,10,11 was decreased and involucrin was increased in infants versus adults. All infants had elevated IL1␣ and reduced TNF␣ versus adults. IL-6, IL-8, and MCP1 were significantly increased in premature versus term infants and adults. Skin surface cortisol and albumin were significantly elevated in premature infants. The biomarker profile in premature infants was unique with differences in structural proteins, albumin, and cytokines IL-6, IL-1␤, IL-8, and MCP1. The higher infant IL1␣ may be associated with skin barrier maturation. The significant elevations in skin surface cortisol for preterm infants may reflect a neuroendocrine response to the stress of premature birth. (Pediatr Res 67: 382-386, 2010)

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Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Cited by 198 publications

References 83 publications

Omega-3 Fatty Acids and Stress-Induced Immune Dysregulation: Implications for Wound Healing

Omega-3 Fatty Acids and Stress-Induced Immune Dysregulation: Implications for Wound Healing

Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Biomarkers of Epidermal Innate Immunity in Premature and Full-Term Infants

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