The Neural Pathway of Reflex Regulation of Electroacupuncture at Orofacial Acupoints on Gastric Functions in Rats

Abstract

Acupuncture has a reflex regulation in gastrointestinal functions, which is characterized with segment. In the present study, the neural pathway of electroacupuncture (EA) at orofacial acupoints (ST2) on gastric myoelectric activity (GMA) in rats was investigated. The results indicated that EA at ST2 facilitated spike bursts of GMA, which is similar to EA at limbs and opposite to EA at abdomen. The excitatory effect was abolished by the transaction of infraorbital nerves, dorsal vagal complex lesion, and vagotomy, respectively. In addition, microinjection of L-glutamate into the nucleus of the solitary tract (NTS) attenuated the excitatory effect. All these data suggest that the dorsal vagal complex is involved in the reflex regulation of EA at orofacial acupoints on gastric functions and NTS-dorsal motor nucleus of the vagus (DMV) inhibitory connections may be essential for it.

Mechanism of Cordyceps Cicadae in Treating Diabetic Nephropathy Based on Network Pharmacology and Molecular Docking Analysis

“…At present, there are effective approaches that can reduce the incidence of diabetic kidney disease and postpone its progression such as controlling blood glucose levels and blood pressure as well as blockade of the renin-angiotensin-aldosterone system [ 3 ]. Many researches of traditional Chinese medicine have also been carried out in the treatment of DN and have made some achievement in recent years, such as berberine [ 4 ], Qidan Dihuang grain (QDDHG) [ 5 ], and Danggui Shaoyao San (DSS) [ 6 ]. The mechanism of action may be multifaceted, such as regulating glucose metabolism, correcting lipid metabolism disorder, inhibiting the activation of polyol pathway, antioxidative stress, improving the structure and function of podocytes, inhibiting inflammatory response, and intervening cell signal transduction.…”