The Nephrotoxicity of Vancomycin

Filippone, Edward J.; Kraft, Walter K.; Farber, John L.

doi:10.1002/cpt.726

Cited by 270 publications

(299 citation statements)

References 103 publications

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“…Our study showed that furosemide was the only type of diuretic that was significantly more likely to be taken by VI-AKI patients concomitantly with VI-AKI in elderly Chinese: single cross-sectional study VAN. This was similar to the results of studies in younger adults [4]. The selection of diuretics in patients receiving VAN may be an important consideration.…”

Section: Discussionsupporting

confidence: 87%

Vancomycin‐induced acute kidney injury in elderly Chinese patients: a single‐centre cross‐sectional study

Pan

Chen

et al. 2018

Brit J Clinical Pharma

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For the elderly Chinese patients treated with VAN, there was insufficient monitoring of SCr, too little use of VAN TDM, and lower rate of patients whose VAN though serum concentrations were not obtained at the correct time. We recommend that hospital managers increase investment in clinical pharmacists, to strengthen professional management. Patients with concomitant hyperuricaemia and on mechanical ventilation and vasopressor therapy should be paid more attention, and a higher serum albumin was determined to be an independent protective factor for VI-AKI.

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Section: Discussionsupporting

confidence: 87%

Vancomycin‐induced acute kidney injury in elderly Chinese patients: a single‐centre cross‐sectional study

Pan

Chen

et al. 2018

Brit J Clinical Pharma

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“…Moreover, increased caspase-8 and -9 activities stimulate extrinsic and intrinsic pathways of apoptosis [19]. High doses of VA have been generally associated with nephrotoxicity which is the main sideeffects of it [20]. Besides nephrotoxicity, other VA toxicities such as red man syndrome, ototoxicity, neutropenia, phlebitis, fever, thrombocytopenia, linear IgA bullous dermatosis, lacrimation, toxic epidermal necrolysis, necrotising cutaneous vasculitis, and Stevens-Johnson syndrome have been reported previously [21].…”

Section: Discussionmentioning

confidence: 99%

The ameliorating effect of silymarin against vancomycin-induced apoptosis and inflammation in rat liver

Güzel¹,

Şahinoğulları²,

Canacankatan³

et al. 2019

jrp

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Silymarin (SL), a flavonolignan complex isolated from seeds of Silybum marianum (Asteraceae), is known for its hepatoprotective, anti-apoptotic, anti-inflammatory, and antioxidant activities. A glycopeptide antibiotic, Vancomycin (VA) which is used for the treatment of serious infections caused by multi-resistant Gram-positive microorganisms has been clinically used for a long time. The aim of the present study was to evaluate potential therapeutic efficiency of SL against VA-induced apoptosis and inflammation using apoptotic (caspase-3, -8, and, -9 enzyme activities) and inflammatory (Tumor necrosis factor-alpha (TNF-α)) markers, and histopathological examinations in rat liver.

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“…However, the significant nephrotoxicity limits the use of vancomycin in daily clinical practice. It has been reported the incidence of VA-AKI ranges from 0% to over 40% [6].…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-associated acute kidney injury in Hong Kong in 2012–2016

et al. 2020

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Background:To study the incidence of vancomycin-associated acute kidney injury (VA-AKI) in Hong Kong and identify risk factors for VA-AKI. Method: Patients with vancomycin prescription and blood level measurement in 2012-2016 were identified using the Hong Kong Hospital Authority Clinical Data Analysis and Reporting System. Acute kidney injury was defined using KDIGO criteria. Patients without creatinine measurements, steady-state trough vancomycin level or who had vancomycin treatment < 3 days were excluded. Results were analyzed using SPSS version 22.0. Logistic regression was used to identify the predictors for VA-AKI. Odds ratio and 95% confidence interval were estimated. Results: One thousand four hundred fifty patients were identified as VA-AKI from 12,758 records in Hong Kong in 2012-2016. The incidence was respectively 10.6, 10.9, 11.3, 12.2, 11.2% from 2012 to 2016. The incidence of VA-AKI was 16.3, 12.2, 11.3 and 6.2% in patients aged 1-12, 12-60, elderly aged > 60 and newborn and infants, respectively. Baseline creatinine, serum trough vancomycin level, systematic disease history including respiratory failure, hypertension, congestive heart failure, chronic renal failure, anemia and type II diabetes, and concomitant diuretics, piperacillin-tazobactam (PTZ) and meropenem prescription were significantly higher in VA-AKI patients older than 12 years. Logistic regression showed that older age group, higher baseline creatinine, serum trough vancomycin level, respiratory failure, chronic renal failure and congestive heart failure, concomitant diuretics, PTZ and meropenem prescription, and longer hospital stay were all associated with increased risk of VA-AKI. Conclusion: The incidence of VA-AKI in Hong Kong is low but shows no decline. Patients with higher baseline creatinine, multi-organ diseases and multiple drugs administration should have their vancomycin level monitored to decrease the risk of VA-AKI.

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The Nephrotoxicity of Vancomycin

Cited by 270 publications

References 103 publications

Vancomycin‐induced acute kidney injury in elderly Chinese patients: a single‐centre cross‐sectional study

Vancomycin‐induced acute kidney injury in elderly Chinese patients: a single‐centre cross‐sectional study

The ameliorating effect of silymarin against vancomycin-induced apoptosis and inflammation in rat liver

Vancomycin-associated acute kidney injury in Hong Kong in 2012–2016

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