The Nephrotic Syndrome

Orth, Stephan R.; Ritz, Eberhard

doi:10.1056/nejm199804233381707

Cited by 406 publications

(279 citation statements)

References 95 publications

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“…The observed non alteration in serum electrolyte in animals treated with the extract compared with the control is an indication that the extract might not have altered renal function in the rats. Alteration in serum levels of Na+ and K+ has been associated with renal function impairment (Halpperin and Kamel, 1998;Orth and Ritz, 1998).…”

Section: Discussionmentioning

confidence: 99%

Kidney and Liver Function Parameters in Alloxan-Induced Diabetic Rats Treated with Aloe Barbadensis Juice Extract

A¹,

Oluwole²,

Babara³

2010

Sierra Leone j. biomed. res.

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Aloe barbadensis juice extract has been reported to possess hypoglycaemic property but the effects of its use on kidney and liver functions in diabetic animals have not been well investigated. This study investigated some biochemical parameters in the liver and kidney of alloxan-induced diabetic rats treated with Aloe barbadensis juice extract. Alloxan-induced diabetic rats were administered orally with Aloe barbadensis juice extract for seven days after which some biochemical indices in the serum, liver and kidney were measured and compared with the control. Serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine of untreated diabetic group and treated diabetic groups were significantly elevated when compared with the normal control group with no significant changes in the levels of the enzymes in the liver and kidney. There were no significant changes (p>0.05) in the serum levels of Na+ and K+ in untreated diabetic group and treated diabetic groups when compared with the normal control rats which are not diabetic. These results suggest that administration of aqueous extract of Aloe barbadensis to diabetic rats did not have any adverse effect on the liver and kidney functions in rats showing that the extract is not toxic to man.

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Section: Discussionmentioning

confidence: 99%

Kidney and Liver Function Parameters in Alloxan-Induced Diabetic Rats Treated with Aloe Barbadensis Juice Extract

A¹,

Oluwole²,

Babara³

2010

Sierra Leone j. biomed. res.

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“…This might be due to increased synthesis from the damaged kidney cells caused by malaria parasites (Orth and Ritz, 1998). Serum urea has been reported to increase in acute and chronic intrinsic renal disease (Cameron and Greger, 1998) and also when there is decreased effective circulating blood volume with decreased renal perfusion (Orth and Ritz, 1998). Increase in serum creatinine has also been reported to arise from intrinsic renal lesions, decreased perfusion of the kidney, or obstruction of lower urinary tract malaria infection (Cameron and Greger, 1998).…”

Section: Discussionmentioning

confidence: 99%

Plasmodium Falciparum-Induced Kidney and Liver Dysfunction in Malaria Patients in Freetown, Sierra Leone

Oyewole¹,

Senusie²,

Mansaray³

2010

Sierra Leone j. biomed. res.

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This study was undertaken to investigate the effect of Plasmodium falciparum infection on kidney and liver function parameters in malaria patients in Freetown, Sierra Leone. Blood samples taken from 64 malaria patients and 64 non-malaria volunteers at Abanita and Blue Shield Hospitals, Freetown Sierra Leone between January to April, 2009 were examined. Changes in serum biochemical parameters were analysed using normal range values as baseline. Serum bilirubin, alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations were significantly elevated in falciparum malaria patients compared to their non-malaria counterparts which is an indication of defective liver function. Most of patients with falciparum malaria also have significantly high serum concentrations of urea, creatinine, sodium and potassium showing alteration in kidney function. This study suggests that malaria parasites could be responsible for derangement of kidney and liver functions in patients and could therefore contribute to organ damage in affected individuals if not treated.

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“…Nephrotic syndrome in diabetic and nondiabetic individuals is associated with a number of disorders that have been implicated in CVD, such as extreme dyslipidemia and hypercoagulability, and is reviewed elsewhere. 101,102 The goal of this review is to highlight the importance of lower levels of proteinuria.…”

Section: Cvd In Nondiabetic Kidney Diseasementioning

confidence: 99%