Kidney and Liver Function Parameters in Alloxan-Induced Diabetic Rats Treated with Aloe Barbadensis Juice Extract

Abstract

Aloe barbadensis juice extract has been reported to possess hypoglycaemic property but the effects of its use on kidney and liver functions in diabetic animals have not been well investigated. This study investigated some biochemical parameters in the liver and kidney of alloxan-induced diabetic rats treated with Aloe barbadensis juice extract. Alloxan-induced diabetic rats were administered orally with Aloe barbadensis juice extract for seven days after which some biochemical indices in the serum, liver and kidney were measured and compared with the control. Serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine of untreated diabetic group and treated diabetic groups were significantly elevated when compared with the normal control group with no significant changes in the levels of the enzymes in the liver and kidney. There were no significant changes (p>0.05) in the serum levels of Na+ and K+ in untreated diabetic group and treated diabetic groups when compared with the normal control rats which are not diabetic. These results suggest that administration of aqueous extract of Aloe barbadensis to diabetic rats did not have any adverse effect on the liver and kidney functions in rats showing that the extract is not toxic to man.

Use of unripe plantain (Musa paradisiaca) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats

“…Measurement of enzymic activities of aminotransferases (AST and ALT) and phosphatases is of clinical and toxicological importance as changes in their activities are indicative of tissue damage by toxicants or in disease conditions [10,21,22].…”

“…While some authors reported increased activities of AST, ALT [24,25], and ALP [21,26] in the liver of alloxan and streptozotocin diabetic rat models, some others reported no alteration in the levels of these enzymes in the liver of diabetic rats [22]. In a study carried out by Sing et al [8], they reported a nonsignifi cant decrease in the activities of AST and ALT in the liver of streptozotocin diabetic rat models but a signifi cant increase in the activity of ALP in the liver of streptozotocin diabetic rat models.…”

Biochemical and Haematological Effects of the Leaf Extract of <i>Newbouldia laevis</i> in Alloxan-Induced Diabetic Rats

“…Studies have reported the altered biochemical parameters of the liver and kidney functions, and haematological parameters following the administration of alloxan and / or extracts of medicinal plants [20] [21]. Mansi and Lehham [22] reported alteration in various haematological parameters and the immune system during the course of diabetes.…”

Pharmacological potential of methanol extract of Anacardium occidentale stem bark on alloxan-induced diabetic rats

“…The plant is commonly referred to as cashew in English, kashu in Hausa, and kaju in Yoruba. It has a thick and tortuous trunk with branches so winding that they frequently reach the ground [6]. The cashew tree produces many resources and products.…”