Use of unripe plantain (<i>Musa paradisiaca</i>) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats

Eleazu, Chinedum; Okafor, P.N.

doi:10.1556/imas.7.2015.1.2

Cited by 23 publications

(27 citation statements)

References 27 publications

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“…The studies occurred in nine different countries: England [41], Sweden [42,43], Bangladesh [44,45,46], Jamaica [47], Venezuela [48], Mexico [49], Brazil [50,51,52,53,54], Nigeria [55], and India [56] (Supplementary file Figure S1) between 1984 and 2019 (Table 1). Almost 40% ( n = 7) of the studies were conducted in Brazil [50,51,52,53,54], probably due to the Brazilian banana production corresponding for about 15% of the worldwide banana production.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the ingredients or foods used in the research, ten studies were conducted with green banana flour [41,43,49,50,51,52,53,55,56,59] and eight with the green banana pulp/biomass [42,44,45,46,47,48,54,60]. Most of the studies used green banana flour, probably due to the highest shelf-life and stability of the product compared to the green banana pulp/biomass [61], and this product is well characterized in the scientific literature.…”

Section: Resultsmentioning

confidence: 99%

“…However, this product tends to be expensive and not accessible in some countries [10,32,36,62,63,64,65,66,67,68,69,70,71,72], stimulating the utilization of green banana pulp/biomass in some products. Considering the type of research method, 14 of the studies were performed in vivo [41,42,44,45,46,47,48,49,51,52,54,55,59,60], one conducted in vitro [56], and three studies used both in vivo and in vitro methods [43,50,53].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Health Benefits of Green Banana Consumption: A Systematic Review

Falcomer

Riquette²,

Romão

et al. 2019

Nutrients

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Despite the growing demand for green banana (GB) products, there is no review study regarding their potential health benefits. We aimed to compare the health benefits among different GB products by a systematic review. We researched six electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, and Google Scholar) from inception to March 2019. We found 1009 articles in these databases. After duplicate removal, we screened 732 articles’ titles and abstracts, and selected 18 potentially relevant studies for full-text reading. We added five records from the reference list of the fully-read articles and seven suggested by the expert. Twelve articles were excluded. In the end, 18 studies were considered for this systematic review. Ten studies were conducted with green banana flour and eight with the green banana pulp/biomass. Most of the GB health benefits studied were related to the gastrointestinal symptoms/diseases, followed by the glycemic/insulin metabolism, weight control, and renal and liver complications associated to diabetes. Only one study did not confirm the health benefit proposed. It is necessary to standardize the GB dose/effect to different age groups and different health effects considering the GB variety and ripeness level. Further studies are necessary to present better detailing of GB product and their health effects considering all the raw-material characteristics.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Health Benefits of Green Banana Consumption: A Systematic Review

Falcomer

Riquette²,

Romão

et al. 2019

Nutrients

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“…The use of unripe M. paradisiaca in the management of diabetes and hepatic dysfunction in STZ-induced diabetes in rats was assessed by Eleazu and Okafor [30]. The authors reported that intake of unripe extract by diabetic rats resulted in a significant decrease in blood glucose when compared to diabetic control rats; urine glucose and protein decreased with time following treatment with extract of unripe M. paradisiaca.…”

Section: Antidiabetic Activity Of M Paradisiacamentioning

confidence: 99%

Antidiabetic, Anti-Inflammatory, Antibacterial, Anti-Helminthic, Antioxidant and Nutritional Potential of Musa Paradisiaca

Oguntibeju

2019

Asian J Pharm Clin Res

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The medicinal and economic values of medicinal plants remain vital to the well-being, growth, and development of humans, especially those living in developing countries. It has been shown that due to the availability, less side effects, general acceptance by local people, medicinal plants contribute significantly to improving health-care delivery system by supplying important pharmaceutical and pharmacological ingredients that are affordable to the teaming majority of people. It is estimated that 30% of pharmaceutical products that are sold globally is rich in compounds derived from plant materials. It is also of interest to report that over 80% of the people in developing countries, mostly in Asia and Africa depend heavily on plant products in the treatment and management of various disease conditions. The interest in demand and utilization of medicinal plants has also increased significantly due to the high cost of orthodox medications, lack of good transportation, lack of storage facilities, inadequate availability of health professionals, and lack of the will and political power to provide basic health needs for the citizens of these developing countries. Musa paradisiaca is one of such medicinal plants believed to have multi-faceted health benefits and its health benefits extend to different countries of the world. It is a stable crop found in Asia, Africa, and Central and South America commonly consumed as energy-yielding food but with many medicinal values as well. It is used in the treatment and management of diabetes mellitus, inflammation, parasitic infection, microbial infections, renal, and liver dysfunction. This manuscript focuses on the antidiabetic, antioxidant, anti-inflammatory, antimicrobial, anti-helminthic, and nutritional values of M. paradisiaca.

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“…Evidence suggests that levels of TBARS, a marker of oxidative stress are markedly increased in the liver and pancreas during the progression of diabetes, and that, this plays a major role in pancreatic and hepatocyte damage associated with diabetes [40]. Regeneration of the pancreatic beta cells is one of the proposed mechanisms by which, plant-based drugs are believed to lower blood glucose in STZ-induced diabetic rats because the regenerated beta cells increase the capacity of the endocrine pancreas to synthesize and release insulin, which in turn, promotes cellular glucose utilization [41]. Evaluation of relative vital organs weight showed that EEA-treated diabetic rats had significantly increased liver and pancreatic weights when compared with the diabetic untreated control group.…”

Section: Disscussionmentioning

confidence: 99%

Evaluation of Antidiabetic and Antioxidant Effects of Ethanolic Leaf Extract of Erythrina Abbysinica Lam, Ex Dc

Rexon

Masopera

Shauli

et al. 2018

Asian J Pharm Clin Res

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Objective: This study was conducted to scientifically evaluate the antidiabetic and antioxidant effects of ethanolic leaf extract of Erythrina abbysinica (EEA).Methods: Acute and sub-chronic effects of EEA at 100, 200, and 400 mg/kg/bwt and glibenclamide (GL) at 5 mg/kg/bwt. were evaluated in both normal and streptozotocin (STZ)-induced diabetic male Wistar rats (250–300 g). The acute studies were performed using oral glucose tolerance test (OGTT). In sub-chronic studies, animals were orally administered with EEA and GL daily for 6 w. Brine shrimp assay was used to determine the toxicity of EEA. 1, 1-diphenyl-2-picrylhydrazyl, ferric reducing capacity of plasma, and thiobarbituric acid reactive substances assays were used to determine antioxidant properties of EEA.Results: Following OGTT, EEA significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in both normal and STZ-induced diabetic rats when compared with positive and negative control counterparts at all-time points, whereas GL significantly (p<0.05) decreased blood glucose only in normal rats but not in diabetic rats. Daily, oral administration of EEA for 6 w significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in STZ-induced diabetic rats when compared with the diabetic control group. EEA revealed weak toxicity with a lethal concentration50 value of 997 μg/ml). Furthermore, EEA showed significant free radical scavenging, total antioxidant, and anti-lipid peroxidative capacities.Conclusion: The study has shed more light on the scientific basis for the use of E. abbysinica in management of diabetes in some communities of Eastern Cape of South Africa.

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Use of unripe plantain (Musa paradisiaca) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats

Cited by 23 publications

References 27 publications

Health Benefits of Green Banana Consumption: A Systematic Review

Health Benefits of Green Banana Consumption: A Systematic Review

Antidiabetic, Anti-Inflammatory, Antibacterial, Anti-Helminthic, Antioxidant and Nutritional Potential of Musa Paradisiaca

Evaluation of Antidiabetic and Antioxidant Effects of Ethanolic Leaf Extract of Erythrina Abbysinica Lam, Ex Dc

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