The nephrogenic hepatic dysfunction syndrome: A review

Strickland, Raymond C.; Schenker, Steven

doi:10.1007/bf01077398

Cited by 28 publications

(8 citation statements)

References 24 publications

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“…This form of cholestasis has been observed in patients with non‐metastatic renal cell carcinoma (Stauffer’s syndrome), soft tissue sarcomas and malignant lymphomas, in particular, Hodgkin’s disease. 64–70 The underlying mechanisms are unknown, but cholestasis has been ascribed to effects of paraneoplastic mediators released by the tumour, in particular cytokines released by inflammatory cells surrounding/ infiltrating the tumour. 7,11 Idiopathic paraneoplastic cholestasis usually disappears after removal and/or successful treatment of the tumour.…”

Section: Clinical Spectrum Of Inflammation‐induced Cholestasismentioning

confidence: 99%

Inflammation-induced cholestasis

Trauner

Fickert

Stauber

1999

J Gastroenterol Hepatol

217

165

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Inflammatory cytokines produced in response to various infectious and non‐infectious stimuli are potent inducers of intrahepatic cholestasis (inflammation‐induced cholestasis). The cholestatic effect of cytokines results mainly from inhibition of expression and function of hepatocellular transport systems which normally mediate hepatic uptake and biliary excretion of bile salts and various non‐bile salt organic anions (e.g. bilirubin). These cytokine effects are reversible and bile secretory function is restored upon disappearance of the inflammatory injury. This review summarizes the clinical, pathophysiological and molecular aspects of inflammation‐induced cholestasis. © 1999 Blackwell Science Asia Pty Ltd

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Section: Clinical Spectrum Of Inflammation‐induced Cholestasismentioning

confidence: 99%

Inflammation-induced cholestasis

Trauner

Fickert

Stauber

1999

J Gastroenterol Hepatol

217

165

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“…This study has also provided further evidence of the association of this syndrome with the presence of fever, anaemia, weight loss and a raised ESR. These features are present in a high pro-portion of cases and may form part of the syndrome (Strickland and Schenker, 1977).…”

Section: Discussionmentioning

confidence: 99%

“…The syndrome of non-metastatic hepatic dysfunction was first described in 5 patients with renal carcinoma who developed hepatomegaly and abnormal liver function without evidence of hepatic metastases (Stauffer, 1961). An incidence of 4 to 15% has been subsequently reported in the literature (Walsh and Kissane, 1968;Warren et al, 1970;Ramos and Taylor, 1972;Strickland and Schenker, 1977;Boxer et al, 1978) but little information has been given about the outcome, and the significance of this condition remains uncertain.…”

mentioning

confidence: 99%

Hepatic Dysfunction in Renal Carcinoma

Fletcher

Packham

Pryor

et al. 1981

British Journal of Urology

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In a retrospective review of 81 patients with renal carcinoma 34 (42%) had abnormalities of one or more liver function tests. Fifteen patients (18.5%) had abnormalities of 3 or more liver function tests but without evidence of hepatic metastases. There was a significant association between these patients and the presence of fever, anaemia, weight loss and a raised ESR (P less than 0.001) compared with those whose liver function was normal. Following nephrectomy, liver function returned to normal in 5 patients. Median survival in these patients was 35 months, whilst in those whose liver function remained abnormal the median survival was 8 months (P less than 0.01).

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“…It has also been suggested that the occurrence of Stauffer's syndrome may be an early indicator of recurrence after surgical resection or tumor metastases [15,16] . The initial reports by Stauffer and others have described the classic, or anincteric, form of the NMHD in the setting of renal tumors [1,17] . In comparison, the first case of the cholestatic, or icteric, variant of Stauffer's syndrome was reported by Dourakis et al in 1997 [18] .…”

Section: Al-taee Am Et Al Non-metastatic Hepatic Dysfunctionmentioning

confidence: 99%

An Unusual Case of Cholestatic Hepatitis

Al-Taee

Gremida

Cheung

et al. 2017

Journal of Gastroenterology and Hepatology Research

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resection of the primary tumor. Here we present an unusual case of non-metastatic hepatic dysfunction secondary to renal cell carcinoma, also known as Stauffer's syndrome, in a 55-year old patient who presented with liver synthetic dysfunction and notable hyperbilirubinemia. Unlike earlier reports, the icteric variant of Staffer's syndrome has been emerging as the predominantly reported variant in the recent literature. Moreover, poor correlation between the severity of hepatic dysfunction and the liver biopsy findings was noted. The variable and non-specific presenting symptoms and signs as well as the need for extensive evaluation for abnormal liver chemistry usually results in a delay in the diagnosis of the primary tumor. Therefore, physicians need to be familiar with this clinical entity as a possible reversible etiology of liver chemistry abnormalities in patients with renal and other solid tumors as this may guide further investigations, lead to earlier diagnosis and treatment of the primary tumor, and ultimately improve outcomes. INTRODUCTIONNon-metastatic hepatic dysfunction secondary to renal cell carcinoma, also known as Stauffer's syndrome, was first described by Stauffer in 1961 [1] . The pathophysiology has not been completely elucidated so far. Surgical resection of the primary tumor is characteristically associated with reversal of liver chemistry abnormalities [2] . CASE PRESENTATIONA 55-year-old Caucasian male with a past medical history of type 2 diabetes mellitus and benign prostatic hyperplasia presented to the emergency room with the chief complaint of worsening abdominal ABSTRACTRenal cell carcinoma can present with a variety of paraneoplastic syndromes. Reversible hepatic dysfunction in the setting of nonmetastatic renal cell carcinoma is a rare paraneoplastic phenomenon that was first described by Stauffer in 1961. This clinical entity is characterized by reversal of liver chemistry abnormalities after CASE REPORT

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The nephrogenic hepatic dysfunction syndrome: A review

Cited by 28 publications

References 24 publications

Inflammation-induced cholestasis

Inflammation-induced cholestasis

Hepatic Dysfunction in Renal Carcinoma

An Unusual Case of Cholestatic Hepatitis

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