The Neonicotinoid Insecticide Imidacloprid: A Male Reproductive System Toxicity Inducer-Human and Experimental Study

Hafez, Essam M.; Issa, Sahar Y.; AI-Mazroua, Maha K; Ibrahim, Karem T; Rahman, Safaa M Abdel

doi:10.4172/2476-2067.1000109

Cited by 17 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the deterioration of spermatozoa characteristics noted in this study could be attributed to the significant reduction in LH, FSH and testosterone. Our results are similar to those of Hahez et al who demonstrated that in IMI-exposed rats, spermatozoa damage was associated with a decrease in sex hormones [9]. Moreover, this decrease in plasmatic LH and FSH could be partly explained by the oxidative potentials of IMI on the central nervous system [3].…”

Section: Discussionsupporting

confidence: 91%

“…However, several studies have reported considerable damaging effects of this insecticide on rats nervous, excretory and reproductive systems. Indeed, a significant decrease in spermatozoa count, motility and viability associated with a decrease in sexual hormones and severe testis histological damages were reported in rats treated with IMI [5, 8, 9]. Oxidative stress which results from imbalance in the body’s oxidants and antioxidants in favor of the first is said to be the underlying mechanism generating these damages [10, 11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

Tetsatsi

Nkeng-Effouet

Alumeti

et al. 2019

Basic Clin. Androl.

View full text Add to dashboard Cite

Background: Imidacloprid, a neonicotinoid insecticide, has been associated to severe reproductive toxicity in mammals. Although some preventive measures have been reported, curative strategies are yet to be explored. The present study was designed to investigate the alleviating effects of Lannea acida on the reproductive toxicity of colibri®, a commercial formulation of imidacloprid, in adult male rats. Materials and methods: Seventy rats were orally administered with colibri® (22.5 mg/kg, 10 mL/kg) for 14 days and treated for other 14 or 28 days with either aqueous or methanol extracts of L. acida (170 or 340 mg/kg). Control animals were similarly treated with clomiphene citrate or vitamin E. Sexual organ weights, spermatozoa characteristics, sexual hormones, stress markers and testis histology were evaluated at the end of each treatment period. Results: Colibri® exposition induced reproductive toxicity marked by a decrease in sex organ weights, spermatozoa count, motility and viability. Colibri® also decreased testosterone, luteinizing hormone, follicle stimulating hormone concentrations and increased testicular oxidative stress. Spermatozoa morphology and testis histology were also severely altered. Similar to clomiphene citrate and vitamin E, treatment with L. acida extracts significantly (p ≤ 0.05-0.001) reversed the above-mentioned damages, especially after 28 days of treatment with aqueous (340 mg/kg) and methanol (170 mg/kg) extracts. Conclusion: Present results indicate that L. acida exerts curative effects against colibri®-induced male reproductive toxicity. These results justify the use of this plant as fertility enhancer and suggest that it could be an alternative in the management of pesticide-derived male infertility.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

Tetsatsi

Nkeng-Effouet

Alumeti

et al. 2019

Basic Clin. Androl.

View full text Add to dashboard Cite

show abstract

“…Studies conducted in male and female laboratory animals, mostly rats, have established that oral administration of imidacloprid could affect reproductive function, as summarised in Table 1 (20)(21)(22)(23)(24)(25)(26)(27)(28). Subchronic and chronic exposure to different doses of imidacloprid can cause histological damage of the testicular tissue, changes in sperm morphology, increased sperm mortality and abnormality, decreased sperm count and motility, inhibited spermatogenesis, and reduced testosterone levels in male rats, all of which could lead to infertility (20)(21)(22)(23)(24).…”

Section: Reproductive Toxicitymentioning

confidence: 99%

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Mikolić

Karačonji

2018

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Imidacloprid, a neonicotinoid insecticide, has been used worldwide due to its selective toxicity for insects. Its residues may enter the food chain, which is why it is important to investigate the potential adverse effects of imidacloprid exposure. This review summarises current knowledge of the reproductive toxicity and disruptive endocrine effects of imidacloprid in laboratory animals. Investigations, conducted mostly on laboratory rats, have shown adverse effects of imidacloprid on the reproductive ability in both parental and offspring generation as well as on the development of the offspring. Like many pesticides, imidacloprid may also act as endocrine disrupting chemical (EDC). It may disrupt the metabolic homeostasis, contribute to obesity, and disrupt steroidogenesis by inhibiting cytochrome P450 (CYP) enzyme activities. All these adverse effects of imidacloprid may pose a serious risk for reproduction and development with long-term consequences in adulthood.

show abstract

“…In terms of reproductive toxicity, it has been shown that the NN clothianidin (CLO), causes the DNA fragmentation of germ cells and the inhibition of embryonic development in mature quail [ 18 , 19 , 37 ]. Another NN, imidacloprid, has been reported to cause significant changes in ovarian morphology and in follicle stimulating hormone (FSH), luteinizing hormone (LH), and progesterone levels in female rats [ 21 ] and to decrease testosterone levels in male rats [ 12 ]. We recently reported that CLO passes rapidly through the placental barrier in mice [ 27 ].…”

mentioning

confidence: 99%

Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

et al. 2021

View full text Add to dashboard Cite

Recently, developmental exposure to clothianidin (CLO) has been shown to cause reproductive toxicity in male mice, but the effects in female mice remain to be clarified. Pregnant C57BL/6N mice were given a no-observed-adverse-effect-level (NOAEL) dose of CLO until weaning. We then examined ovaries of 3-or 10-week-old female offspring. In the CLO-administered group, morphological changes, a decrease in the immunoreactivity of the antioxidant enzyme glutathione peroxidase 4 (GPx4), and activation of genes in the steroid hormone biosynthesis pathway were observed in 3-week-old mice, and decreases of GPx4 immunoreactivity, 17OH-progesterone and corticosterone levels were observed in 10-week-old mice, along with high rates of infanticide and severe neglect, providing new evidence that developmental exposure to CLO affects juvenile and adult mice differently.

show abstract

The Neonicotinoid Insecticide Imidacloprid: A Male Reproductive System Toxicity Inducer-Human and Experimental Study

Cited by 17 publications

References 20 publications

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

Contact Info

Product

Resources

About