The ‘Neglected’ Personal Neglect

Caggiano, Pietro; Jehkonen, Mervi

doi:10.1007/s11065-018-9394-4

Cited by 36 publications

(39 citation statements)

References 117 publications

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“…The combined assessment of visual and personal neglect in our sample enabled us to evaluate the possibility of dissociated patterns of performance. Our results confirmed that MN can occur in the absence of signs of visual neglect [2], or of personal neglect [35]. The dissociation from personal neglect is of theoretical relevance, because it challenges the hypothesis that all MN patients simply do not pay attention to their contralesional limbs.…”

Section: Discussionsupporting

confidence: 77%

“…Actigraphy showed asymmetric motor behavior in all these patients, plus three more.The combined assessment of visual and personal neglect in our sample enabled us to evaluate the possibility of dissociated patterns of performance. Our results confirmed that MN can occur in the absence of signs of visual neglect[2], or of personal neglect[35]. The dissociation from personal neglect is of theoretical relevance, because it challenges the hypothesis that all MN patients simply do not pay attention to their contralesional limbs.In a subset of 25 right-brain damaged patients, we explored the lesional correlates of MN.Lesion location was heterogeneous, but frequently involved the white matter, including corticospinal tracts and long-range fronto-parietal and fronto-occipital fascicles.…”

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confidence: 76%

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Quantitative assessment of motor neglect

Toba

Pagliari

Rabuffetti

et al. 2020

Preprint

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Objectives. Patients with unilateral brain damage may avoid moving the limbs contralateral to their lesion, even in the absence of sensorimotor deficits. However, when asked to move their limbs these patients typically show normal strength and dexterity. In their seminal 1983 article on the Journal of Neurology, Neurosurgery and Psychiatry, Laplane and Degos dubbed this condition Motor Neglect (MN). MN can mimic hemiplegia, with severe clinical consequences. Its assessment has thus important clinical implications. However, MN diagnosis is at present highly subjective, because it is based on the clinical observation of patients' spontaneous motor behaviour. Here we introduce differential actigraphy as a novel, objective method to quantify MN. Methods. Patients wear wristwatch-like accelerometers, which record spontaneous motor activity of their upper limbs during 24 hours. Asymmetries of motor behaviour are then automatically computed offline. On the basis of normal participants' performance, we calculated cut-off scores of left/right motor asymmetry. Results. Differential actigraphy showed contralesional MN in nine of 35 patients with unilateral strokes, consistent with clinical assessment. An additional patient with clinical signs of MN obtained a borderline asymmetry score. Lesion location in a subgroup of 25 patients was highly variable, suggesting that MN is a heterogenous condition. Conclusions. Differential actigraphy provides an ecological measure of spontaneous motor behaviour, and can assess upper limb motricity in an objective and quantitative manner. It thus offers a convenient, cost-effective, and relatively automatized procedure for following-up motor behaviour in neurological patients, and to assess the effects of rehabilitation.

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Section: Discussionsupporting

confidence: 77%

supporting

confidence: 76%

Quantitative assessment of motor neglect

Toba

Pagliari

Rabuffetti

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…To our knowledge, there are no investigations of potential lateralisation effects in the context of illusory full-body ownership perception. Future experimental studies should thoroughly examine this issue because we need to learn more about lateralisation in body ownership illusions and clarify how this relates to the literature on lateralisation of body representation [ 69 , 70 ], as well as neurological disorders of body representation [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

The contribution of stimulating multiple body parts simultaneously to the illusion of owning an entire artificial body

O'Kane

Ehrsson

2021

PLoS ONE

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The full-body ownership illusion exploits multisensory perception to induce a feeling of ownership of an entire artificial body. Although previous research has shown that synchronous visuotactile stimulation of a single body part is sufficient for illusory ownership of the whole body, the effect of combining multisensory stimulation across multiple body parts remains unknown. Therefore, 48 healthy adults participated in a full-body ownership illusion with conditions involving synchronous (illusion) or asynchronous (control) visuotactile stimulation to one, two, or three body parts simultaneously (2×3 design). We used questionnaires to isolate illusory ownership of five specific body parts (left arm, right arm, trunk, left leg, right leg) from the full-body ownership experience and sought to test not only for increased ownership in synchronous versus asynchronous conditions but also for potentially varying degrees of full-body ownership illusion intensity related to the number of body parts stimulated. Illusory full-body ownership and all five body-part ownership ratings were significantly higher following synchronous stimulation than asynchronous stimulation (p-values < .01). Since non-stimulated body parts also received significantly increased ownership ratings following synchronous stimulation, the results are consistent with an illusion that engages the entire body. Furthermore, we noted that ownership ratings for right body parts (which were often but not always stimulated in this experiment) were significantly higher than ownership ratings for left body parts (which were never stimulated). Regarding the effect of stimulating multiple body parts simultaneously on explicit full-body ownership ratings, there was no evidence of a significant main effect of the number of stimulations (p = .850) or any significant interaction with stimulation synchronicity (p = .160), as assessed by linear mixed modelling. Instead, median ratings indicated a moderate affirmation (+1) of an illusory full-body sensation in all three synchronous conditions, a finding mirrored by comparable full-body illusion onset times. In sum, illusory full-body ownership appears to be an ‘all-or-nothing’ phenomenon and depends upon the synchronicity of visuotactile stimulation, irrespective of the number of stimulated body parts.

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“…Building a coherent representation of space entails a complex integration of different sensory inputs and output-related factors, in relation to different portions of space and coordinates systems. Coherently with this assumption, USN symptoms can dissociate across sensory modalities, 9 sectors of space (i.e., personal, peri-personal and extra-personal space [10][11][12][13][14], reference frames (egocentric vs allocentric neglect [15][16][17], and tasks. 18 An often neglected dissociation concerns symptoms affecting perceptual and output stages of spatial processing.…”

Section: Usn Is a Complex Syndromementioning

confidence: 99%

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Gammeri¹,

Iacono²,

Ricci

et al. 2020

NDT

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Introduction: Unilateral spatial neglect (USN) is a disorder of contralesional space awareness which often follows unilateral brain lesion. Since USN impairs awareness of contralesional space/body and often of concomitant motor disorders, its presence represents a negative prognostic factor of functional recovery. Thus, the disorder needs to be carefully diagnosed and treated. Here, we attempted to present a clear and concise picture of current insights in the comprehension and rehabilitation of USN. Methods: We first provided an updated overview of USN clinical and neuroanatomical features and then highlighted recent progresses in the diagnosis and rehabilitation of the disease. In relation to USN rehabilitation, we conducted a MEDLINE literature research on three of the most promising interventions for USN rehabilitation: prismatic adaptation (PA), non-invasive brain stimulation (NIBS), and virtual reality (VR). The identified studies were classified according to the strength of their methods. Results: The last years have witnessed a relative decrement of interest in the study of neuropsychological disorders of spatial awareness in USN, but a relative increase in the study of potential interventions for its rehabilitation. Although optimal protocols still need to be defined, high-quality studies have demonstrated the efficacy of PA, TMS and tDCS interventions for the treatment of USN. In addition, preliminary investigations are suggesting the potentials of GVS and VR approaches for USN rehabilitation. Conclusion: Advancing neuropsychological and neuroscience tools to investigate USN pathophysiology is a necessary step to identify effective rehabilitation treatments and to foster our understanding of neurofunctional bases of spatial cognition in the healthy brain.

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The ‘Neglected’ Personal Neglect

Cited by 36 publications

References 117 publications

Quantitative assessment of motor neglect

Quantitative assessment of motor neglect

The contribution of stimulating multiple body parts simultaneously to the illusion of owning an entire artificial body

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

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