The need to identify novel biomarkers for prediction of premature ovarian insufficiency (POI)

Kabodmehri, Roya; Sharami, Seyedeh Hajar; Sorouri, Zahra Rafiei; Gashti, Nasrin Ghanami

doi:10.1186/s43043-022-00100-y

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…AFM in plasma specifically binds vitamin E. AFM concentrations in peritoneal fluid are directly related to the level of oxidative stress in endometriosis 79 and are correlated with vitamin E concentrations. AFM is inversely proportional to the degree of progression of endometriosis, and its concentrations are reduced in follicular and peritoneal fluid in more pronounced diseases 80 . However, extremely high concentrations of AFM were detected in the serum of women with premature ovarian failure 81,82 .…”

Section: Discussionmentioning

confidence: 99%

“…AFM is inversely proportional to the degree of progression of endometriosis, and its concentrations are reduced in follicular and peritoneal fluid in more pronounced diseases. 80 However, extremely high concentrations of AFM were detected in the serum of women with premature ovarian failure. 81,82 According to results of this research, proteins that balance cellular oxidative damage are significantly lower,…”

Section: Proteins With Function In Antioxidant Activitymentioning

confidence: 99%

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Identification of urine biomarkers of endometriosis—Protein mass spectrometry

Višnić,

Barišić,

Čanadi Jurešić

et al. 2024

American J Rep Immunol

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IntroductionEndometriosis is a chronic inflammatory disease that leads to a series of pathological reactions. The basis is a changed proinflammatory activated immune system, which results in more pronounced oxidative stress, disturbed function of proteolysis and cell apoptosis. These processes are crucial in the development of the disease because their dysfunctional activities cause the progression of the disease. It is believed that the proteins excreted in the urine interact with each other and promote pathological processes in endometriosis.MethodsWe analyzed the urine proteome of patients and aimed to detect a potential protein biomarker for endometriosis in the urine proteome. We collected urine samples from 16 patients with endometriosis and 16 patients in the control group with functional ovarian cysts. The diagnosis for all patients was confirmed through pathohistological analysis. After the preanalytical preparation of the urine, chromatography and mass spectrometry (LC‐MS/MS) used the technology of urine proteome analysis.ResultsThe main finding was a significantly different concentration of 14 proteins in the urine samples. We recorded a considerably higher concentration of proteins that have a significant role in activating the immune system (SELL), iron metabolism (HAMP) and cell apoptosis (CHGA) in endometriosis compared to controls. Proteins having an antioxidant function (SOD1) and a role in proteolysis of the extracellular matrix (MMP‐9) were significantly reduced in endometriosis compared to controls.ConclusionConsistent with the known pathogenesis of endometriosis, the study results complement the pathological responses that occur with disease progression.

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Section: Discussionmentioning

confidence: 99%

Section: Proteins With Function In Antioxidant Activitymentioning

confidence: 99%

Identification of urine biomarkers of endometriosis—Protein mass spectrometry

Višnić,

Barišić,

Čanadi Jurešić

et al. 2024

American J Rep Immunol

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Ceruloplasmin and complement C3 are markers of diminished ovarian reserve in premenopausal women

Салимова

Atalyan

Nadeliaeva

et al. 2023

Fundamentalʹnaâ i kliničeskaâ medicina

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Aim. To establish cut-off values for the concentrations of complement C3 and ceruloplasmin, diagnostic markers of reduced antral follicle count (AFC) and anti-Müllerian hormone (AMH) which both indicate diminished ovarian reserve, in women of reproductive age.Materials and Methods. Here we enrolled 864 women (18-40 years of age, average age 31.70 ± 5.14 years) who underwent an annual medical examination in 2017–2019 in the Irkutsk Region and the Republic of Buryatia. Reduced AFC was defined as ≤ 5 antral follicles in each ovary at pelvic ultrasound examination whilst reduced AMH was defined as < 1.2 ng/mL. In total, 112 women had reduced ovarian reserve and 752 were included into the control group. In addition to AMH, we also measured serum prolactin, gonadotropins, inhibin B, estradiol, complement C3, and ceruloplasmin using enzyme-linked immunosorbent assay. The cut-off values were determined by plotting a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC).Results. The cut-off level of complement C3 was 894 (867; 1355.5) mg/mL [AUC: 0.769 (0.635; 0.904)] in women with reduced AFC (≤ 5) and 981.5 (916.5; 1467.5) mg/mL [AUC: 0.62 (0.493; 0.746)] in women with reduced AMH (< 1.2 ng/mL). The cut-off level of ceruloplasmin was 1.745 (1.625; 1.975) mg/mL [AUC: 0.859 (0.759; 0.96)] in women with reduced AFC (≤ 5) and 1.975 (1.665; 2.15) mg/mL, [AUC: 0.662 (0.542; 0.782)] in women with reduced AMH (< 1.2 ng/mL).Conclusion. We have established the cut-off values for the serum complement C3 and ceruloplasmin in women with reduced AFC and AMH, indicators defining diminished ovarian reserve in women of reproductive age.

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The need to identify novel biomarkers for prediction of premature ovarian insufficiency (POI)

Cited by 2 publications

References 59 publications

Identification of urine biomarkers of endometriosis—Protein mass spectrometry

Identification of urine biomarkers of endometriosis—Protein mass spectrometry

Ceruloplasmin and complement C3 are markers of diminished ovarian reserve in premenopausal women

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