Aim. To establish cut-off values for the concentrations of complement C3 and ceruloplasmin, diagnostic markers of reduced antral follicle count (AFC) and anti-Müllerian hormone (AMH) which both indicate diminished ovarian reserve, in women of reproductive age.Materials and Methods. Here we enrolled 864 women (18-40 years of age, average age 31.70 ± 5.14 years) who underwent an annual medical examination in 2017–2019 in the Irkutsk Region and the Republic of Buryatia. Reduced AFC was defined as ≤ 5 antral follicles in each ovary at pelvic ultrasound examination whilst reduced AMH was defined as < 1.2 ng/mL. In total, 112 women had reduced ovarian reserve and 752 were included into the control group. In addition to AMH, we also measured serum prolactin, gonadotropins, inhibin B, estradiol, complement C3, and ceruloplasmin using enzyme-linked immunosorbent assay. The cut-off values were determined by plotting a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC).Results. The cut-off level of complement C3 was 894 (867; 1355.5) mg/mL [AUC: 0.769 (0.635; 0.904)] in women with reduced AFC (≤ 5) and 981.5 (916.5; 1467.5) mg/mL [AUC: 0.62 (0.493; 0.746)] in women with reduced AMH (< 1.2 ng/mL). The cut-off level of ceruloplasmin was 1.745 (1.625; 1.975) mg/mL [AUC: 0.859 (0.759; 0.96)] in women with reduced AFC (≤ 5) and 1.975 (1.665; 2.15) mg/mL, [AUC: 0.662 (0.542; 0.782)] in women with reduced AMH (< 1.2 ng/mL).Conclusion. We have established the cut-off values for the serum complement C3 and ceruloplasmin in women with reduced AFC and AMH, indicators defining diminished ovarian reserve in women of reproductive age.
The objective of the study was to estimate the prevalence and clinical manifestation of decreased ovarian reserve in women of reproductive age from Eastern Siberia
Methods and Results: During a cross-sectional study, performed in 2017-2019 in Irkutsk Region and Buryat Republic (Russia), we invited 1119 women aged 18 to 40 yrs, who underwent an annual preventive medical examination at their place of work. Of 1119 women, 907 women aged 31,78 5,13 years were included in the study. We used clinical, instrumental, and laboratory research methods and statistical analysis. Of the 907 women included in the study, 117 participants 12.9% had a follicle number per ovary of less than 5 and were diagnosed as patients with decreased ovarian reserve (DOR). According to the laboratory study, 56 out of 117 (47.8%) AMH was below 1.2 ng/ml. The average value of which was 0.53 0.43 ng/ml. In women with reduced AMH levels, a shortening of the menstrual cycle and high parity were observed. Also, in 4 of 117 (3,4%) patients with a reduced number of antral follicles, premature ovarian failure was diagnosed.
Conclusion: Determination of ovarian reserve by one AFC parameter may be useful for determining the risk group of women with premature ovarian insufficiency.
Современные представления о клинико-диагностических критериях преждевременной недостаточности яичников (обзор литературы)Салимова М.д., наделяева я.г., данусевич и.н.
преждевременная недостаточность яичников в популяционной выборке женщин прибайкальского региона: распространённость и возрастные особенности * Салимова М.д., наделяева я.г.
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