The need for neurologists in the care of COVID‐19 patients

Sellner, Johann; Taba, Pille; Öztürk, Şerefnur; Helbok, Raimund

doi:10.1111/ene.14257

Cited by 43 publications

(47 citation statements)

References 14 publications

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“…The underlying pathophysiology is still not well understood, and includes abnormal host immune responses with autoimmunity and/or direct CNS damage due to viral replication and infiltration ( Desforges, Le Coupanec, 2019 ). More in details, ACE-2 and transmembrane protease, serine 2 (TMPRSS2) are documented co-receptors for SARS-CoV-2 entry and they are expressed in the oligodendrocytes, suggesting a direct involvement of white matter in case of encephalitis related to COVID-19 infection ( Needham et al, 2020 ; Sellner et al, 2020 ). A retrospective study from Turkey ( Kandemirli et al, 2020 ) included 235 patients in ICU, 50 of which (21%) developed neurological symptoms.…”

Section: Neurologic Manifestationsmentioning

confidence: 99%

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Keyhanian

Umeton

Mohit

et al. 2021

Journal of Neuroimmunology

117

146

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Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.

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Section: Neurologic Manifestationsmentioning

confidence: 99%

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Keyhanian

Umeton

Mohit

et al. 2021

Journal of Neuroimmunology

117

146

View full text Add to dashboard Cite

show abstract

“…Os neurologistas são membros importantes da equipe médica no atendimento hospitalar à COVID-19. reorganizing neurology consultation services for in-and outpatient clinics [12][13][14][15] . Although a few retrospective case series have described the occurrence of specific neurological symptoms and signs in COVID-19 patients 3-5 , we were not able to find systematic reports of the real-life experience of consulting neurologists, other than the anecdotal editorial by Bersano and Pantoni 12 .…”

Section: Introductionmentioning

confidence: 99%

Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital

Neto

Guedes

Tuma

et al. 2020

Arq. Neuro-Psiquiatr.

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Background: More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. Furthermore, pre-existing neurological conditions may require special treatment and may be associated with worse outcomes. Notwithstanding, the role of neurologists in COVID-19 is probably underrecognized. Objective: The aim of this study was to report the reasons for requesting neurological consultations by internists and intensivists in a COVID-19-dedicated hospital. Methods: This retrospective study was carried out at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil, a 900-bed COVID-19 dedicated center (including 300 intensive care unit beds). COVID-19 diagnosis was confirmed by SARS-CoV-2-RT-PCR in nasal swabs. All inpatient neurology consultations between March 23rd and May 23rd, 2020 were analyzed. Neurologists performed the neurological exam, assessed all available data to diagnose the neurological condition, and requested additional tests deemed necessary. Difficult diagnoses were established in consensus meetings. After diagnosis, neurologists were involved in the treatment. Results: Neurological consultations were requested for 89 out of 1,208 (7.4%) inpatient COVID admissions during that period. Main neurological diagnoses included: encephalopathy (44.4%), stroke (16.7%), previous neurological diseases (9.0%), seizures (9.0%), neuromuscular disorders (5.6%), other acute brain lesions (3.4%), and other mild nonspecific symptoms (11.2%). Conclusions: Most neurological consultations in a COVID-19-dedicated hospital were requested for severe conditions that could have an impact on the outcome. First-line doctors should be able to recognize neurological symptoms; neurologists are important members of the medical team in COVID-19 hospital care.

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“…We not only want to get insights to the clinical spectrum and course of infectious and parainfectious manifestations from adequately confirmed cases. This can be assured by active involvement of neurologists in the care of COVID-19 patients [15]. Concerted efforts to collect patient data including the EANCore initiative could expand the knowledge about susceptibility, prognostic factors and shortcomings of the current patient care.…”

Section: Discussionmentioning

confidence: 99%