What did we learn from the previous coronavirus epidemics and what can we do better: a neuroinfectiological point of view

Akhvlediani, Tamar; Jelčić, Ilijas; Taba, Pille; Pfausler, Bettina; Steiner, Israel; Sellner, Johann

doi:10.1111/ene.14395

Cited by 12 publications

(13 citation statements)

References 15 publications

(18 reference statements)

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“…Moreover, the epidemics of SARS and MERS led to case reports of neurological symptoms such as seizures, polyneuropathies, large artery cerebral infarctions, and detection of SARS-CoV-1 in CSF. However, these previous epidemics have only spawned a limited number of recorded neurologic cases, and the relationship between SARS, MERS, and neurological complications has been questioned ( Akhvlediani et al, 2020 ).…”

Section: Neuropathological Mechanismsmentioning

confidence: 99%

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

Johansson

Mohamed

Moulin

et al. 2021

Journal of Neuroimmunology

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Section: Neuropathological Mechanismsmentioning

confidence: 99%

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

Johansson

Mohamed

Moulin

et al. 2021

Journal of Neuroimmunology

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“…Eight cases of acute and subacute neurological complications in the form of encephalitis, seizures, leukoencephalopathy, neuropathy or myopathy due to direct viral invasion have been reported for SARS‐CoV‐1 and Middle Eastern respiratory syndrome CoV (MERS‐CoV) [6–8]. Yet, no reports of ATM associated with these two beta‐coronaviruses, which caused epidemics in recent history, are found in the literature [9]. However, the total number of infected individuals for both viruses combined only totaled approximately 11,000 individuals; the frequency may not have been sufficient to notice potentially rarer complications [3].…”

Section: Introductionmentioning

confidence: 99%

Systematic review of cases of acute myelitis in individuals with COVID‐19

Schulte

Hauer

Kunz

et al. 2021

Euro J of Neurology

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Background An incremental number of cases of acute transverse myelitis (ATM) in individuals with ongoing or recent coronavirus disease 2019 (COVID‐19) have been reported. Methods We performed a systematic review of cases of ATM described in the context of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection by screening both articles published and in preprint. Results Twenty cases were identified. There was a slight male predominance (60.0%) and the median age was 56 years. Neurological symptoms first manifested after a mean of 10.3 days from the first onset of classical, mostly respiratory symptoms of COVID‐19. Overall, COVID‐19 severity was relatively mild. PCR of CSF for SARS‐CoV‐2 was negative in all 14 cases examined. Cerebrospinal fluid findings reflected an inflammatory process in most instances (77.8%). Aquaporin‐4 and myelin oligodendrocyte protein (tested in 10 and 9 cases, respectively) antibodies in serum were negative. On MRI, the spinal cord lesions spanned a mean of 9.8 vertebral segments, necrotic‐hemorrhagic transformation was present in three cases and two individuals had additional acute motor axonal neuropathy. More than half of the patients received a second immunotherapy regimen. Over a limited follow‐up period of several weeks, 90% of individuals recovered either partially or near fully. Conclusion Although causality cannot readily be inferred, it is possible that cases of ATM occur para‐ or post‐infectiously in COVID‐19. All identified reports are anecdotal and case descriptions are heterogenous. Whether the condition and the observed radiological characteristics are specific to SARS‐CoV‐2 infection needs to be clarified.

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“…Die Verunsicherung bei Betroffenen, Angehörigen und Behandlern zu Beginn der Pandemie war groß, da erst einmal das potenzielle Risiko, per se aufgrund der MS an COVID-19 zu erkranken, geklärt werden musste [ 6 , 7 ]. Dieser Gedankengang ist nicht unbegründet, liegt doch ein erhöhtes Risiko für Infektionen bei MS-Erkrankten vor [ 8 ].…”

Section: Was Wissen Wir Bislang üBer Covid-19 Und Die Multiple Skleroseunclassified

Einblicke in die Behandlung der Multiplen Sklerose mit Cladribin-Tabletten seit Beginn der COVID-19-Pandemie

Sellner

2021

psychopraxis. neuropraxis

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What did we learn from the previous coronavirus epidemics and what can we do better: a neuroinfectiological point of view

Cited by 12 publications

References 15 publications

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

Systematic review of cases of acute myelitis in individuals with COVID‐19

Einblicke in die Behandlung der Multiplen Sklerose mit Cladribin-Tabletten seit Beginn der COVID-19-Pandemie

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