The Nature of the Inclusion Body of Verruca Vulgaris: A Histochemical Study of Nucleotids

Demonstration of virus particles in human genital warts.

“…These lesions have cytological similarities to skin warts, and some basophilic inclusions were reported in one series (Blank, Buerk, and Weidman, 1951). It is frequently stated that they are caused by the same virus as is responsible for skin warts, the differences in appearance and behaviour of the lesions being accounted for by the variations in the fine structure of the epidermis in which the virus develops.…”

The Shope Papilloma-Carcinoma Complex as a Model for Investigation of Tumor Immunology and Viral Oncology

“…If we are to look for viruses in human tumors, it would be helpful to identify histalogic features that might indicate in which tumors or parts of tumors virus is being produced. Other workers (Bunting, et al, 1952;Block and Godman, 1957;Blank, et al, 1951) have reported a correlation between the presence of nuclear and cytoplasmic inclusion bodies in ver ruca vulgaris and the amount of virus found with the electron microscope. We need more studies of the relation of microscopic structures to the viral content of tumors of animals.…”

Human papova (wart) virus.

“…Inclusion Bodies Intranuclear inclusion bodies have been observed in warts for many years (14,85,90,115,122,136). The inclusions are of two types, eosinophilic and basophilic.…”

“…Basophilic inclusion bodies were first reported in the nuclei of infected cells of the stratum spinosum and stratum granulosum (85). In one study, half of all the warts examined contained cells with basophilic, Feulgen-positive inclusions in the nuclei (14). Ultraviolet microspectrophotometry revealed the growth of the basophilic inclusion material in cells of the stratum granulosum, and its persistence in the stratum corneum even after dissolution of cell structure (71).…”