The Nature of Magnesium Tetany

Greenberg, David M.; Tufts, Elma V.

doi:10.1152/ajplegacy.1938.121.2.416

Cited by 61 publications

(26 citation statements)

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“…Greenberg and Tufts (1938) found experimental evidence that the syndrome in animals differed from that of calcium deficiency, and was due to hyperexcitability at midbrain level rather than at the neuromuscular junction. Hanna et al (1960) concluded that the 'pure' syndrome in man included epileptiform convulsions, ataxia, mental depression, and muscular weakness; they did not observe overt tetany, although a positive Cvostek's sign gave evidence of increased neural excitability.…”

Section: Discussionmentioning

confidence: 99%

Neurological Manifestations of Magnesium Deficiency in Infantile Gastro-enteritis and Malnutrition

Back¹,

Montgomery²,

Ward³

1962

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 99%

Neurological Manifestations of Magnesium Deficiency in Infantile Gastro-enteritis and Malnutrition

Back¹,

Montgomery²,

Ward³

1962

Archives of Disease in Childhood

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“…Magnesium primarily acts to inhibit the excitability of muscles and nerves [38]: Mg has a spasmolytic, anti-tetanic, and anticonvulsive effect. Furthermore Mg has antiarrhythmic [82], vasodilative, and antihypertensive properties [1]; it inhibits platelet aggregation, stabilizes the mastocytes, and acts as an anti-allergen [12].…”

Section: Ptiysioiogicai and Pattioptiysioiogicai Importance Of Magnesiummentioning

confidence: 99%

“…In a pronounced case, it may develop into tetanic syndrome [28] or tetany [15,68]. The term magnesium deficiency tetany (MDT) was coined more than 70 years ago [38,56,79] and is increasingly used in definitive resource works for internal medicine [40,44]. However the term magnesium deficiency syndrome [41] is also often used, providing an imprecise image of the disorder.…”

Section: Introductionmentioning

confidence: 99%

Magnesium deficiency tetany – a congenital magnesium-losing disorder

Liebscher¹,

Liebscher²

2011

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Magnesium deficiency tetany (MDT) is a separate hereditary illness. It occurs more often than is assumed or even diagnosed today. As a consequence the estimated number of undetected cases is high. Neuromuscular symptoms are typical of magnesium deficiency due to neuromuscular hyperexcitability. In a pronounced case, it is referred to as tetany. The aim must be to work toward early detection of the symptoms for magnesium deficiency, giving particular consideration to the underlying genetic regulatory mechanisms of Mg homoeostasis. Most patients suffering from MDT have Mg concentrations in their serum lying in the lower third of the normal range, which, however, should not lead to a misdiagnosis and MDT being erroneously dismissed. An early start of a consistent, causal and lifelong supplementation therapy with sufficiently high Mg doses (600 -1,800 mg, in rare cases up to 20,000 mg Mg per day) and a Mg target value in serum of > 0.9 mmol/1 (in specific cases even higher) can safeguard patient health to a large extent, reduce the risk of secondary diseases, and stave off the need for early retirement. These facts become particularly evident in the numerous case reports of patients.

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“…It was only just before the onset of a convulsion that the heart rate was found to be markedly depressed, although it slowly returned to normal after recovery. However, during the bradycardiaj a marked arrhythmia was present (151,152). Mg 2+ deficient rats without convulsions did not exĥ ibit changes in the heart rate.…”

Section: Cardiac Arrhythmie and Electrocardiogram In Hypomagnesaemiamentioning

confidence: 99%

“…(153,154). Nevertheless, the Mg 2 " 1 " deficient rats terid to have extrasystoles (152,153), Additional electrocardiogram abnormalities in Mg 2+ deficient rats afe lengthened P-R intervals and älterations of the S-T segment (153). In anaesthetized, Mg 2+ deficient rats, later investigators found only a highly significant decrease of the T-wave amplitude but no change of other amplitudes or segments (154).…”

Section: Cardiac Arrhythmie and Electrocardiogram In Hypomagnesaemiamentioning

confidence: 99%