The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis

Oosterlynck, Didier J.; Meuleman, Christel; Waer, Mark; Vandeputte, Michel; Koninckx, Philippe

doi:10.1016/s0015-0282(16)55224-8

Cited by 224 publications

(122 citation statements)

References 16 publications

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“…In addition, depressed NK activity has been reported in patients with endometriosis (30) and in a rat model of experimental endometriosis (31). A significant correlation between reduced peritoneal NK activity and the severity of endometriosis was also reported (32). Hence, we examined the NK activity of mononuclear cells from the peritoneal fluid and spleen as well as IL-1b production by peritoneal macrophages in our rat model.…”

Section: European Journal Of Endocrinology (1998) 138mentioning

confidence: 68%

Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

Katsuki

Takano

Futamura

et al. 1998

European Journal of Endocrinology

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Objective: Dienogest, a synthetic steroid with progestational activity, is used as a component of oral contraceptives and is currently being evaluated clinically for the treatment of endometriosis. The present study was conducted to confirm the effects of dienogest on experimental endometriosis in rats and to elucidate its mechanism of action. Design: Experimental endometriosis induced by autotransplantation of endometrium in rats. Methods: Endometrial implants, immune system, and bone mineral were investigated after 3 weeks of medication. Results: Dienogest (0.1-1 mg/kg per day, p.o.) reduced the endometrial implant volume to the same extent as danazol (100 mg/kg per day, p.o.). Simultaneously, dienogest ameliorated the endometrial implant-induced alterations of the immune system; i.e. it increased the natural killer activity of peritoneal fluid cells and splenic cells, decreased the number of peritoneal fluid cells, and decreased interleukin-1b production by peritoneal macrophages. In contrast, danazol (100 mg/kg per day, p.o.) and buserelin (30 mg/kg per day, s.c.) had none of these immunologic effects. Additionally, combined administration of dienogest (0.1 mg/kg per day) plus buserelin (0.3 mg/kg per day) suppressed the bone mineral loss induced by buserelin alone, with no reduction of the effect on endometrial implants. In vitro studies on dienogest revealed an antiproliferative effect on rat endometrial cells due to inhibition of protein kinase C activity plus a partial progestational effect.Conclusions: Dienogest appears to be a potent agent with mechanisms of action different from those of danazol and GnRH agonists currently available for the treatment of endometriosis. European Journal of Endocrinology 138 216-226

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Section: European Journal Of Endocrinology (1998) 138mentioning

confidence: 68%

Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

Katsuki

Takano

Futamura

et al. 1998

European Journal of Endocrinology

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“…These are weakly cytotoxic but important immune regulators. The phenotypes and functions of the NK cells in the peritoneum and endometrium could contribute to the pathology of EMS (Oosterlynck et al 1992, Ho et al 1995). In the current study, after co-culture with ESCs, the ratio of CD16 + CD56 + NK cells was significantly decreased.…”

Section: Cd56mentioning

confidence: 99%

IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis

Sun

Zhang

et al. 2016

Reproduction

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“…It is well known that women with endometriosis have a decreased cellular immunity and a decreased NK activity in peripheral blood and in peritoneal fluid (8)(9)(10). Stress, which is followed by increased cortisol levels, inhibits NK cell activity.…”

Section: Parameters Analyzedmentioning

confidence: 99%

“…The main conclusions of these studies indicate an increased number of activated macrophages and their immune mediators, which may substantially interfere with reproduction at various levels, including gamete function, fertilization, embryo development, and embryo implantation. Furthermore, women with endometriosis have reduced cellular immunity and more specifically a decreased natural killer (NK) activity in peripheral blood and in peritoneal fluid (8)(9)(10). It is also well known that parameters associated with stress can significantly alter several immunological parameters, including the number of cells as well as their function (for a review, see Ref.…”

Section: Introductionmentioning

confidence: 99%

Prolactin and cortisol levels in women with endometriosis

Lima

Moura

Silva

2006

Braz J Med Biol Res

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The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis

Cited by 224 publications

References 16 publications

Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis

Prolactin and cortisol levels in women with endometriosis

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