IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis

Yu, Jiajun; Sun, Huiting; Zhang, Zhongfang; Shi, Ran; Liu, Libing; Shang, Wen-Qing; Wei, Chunyan; Chang, Kai‐Kai; Shao, Jun; Wang, Mingyan; Li, Ming‐Qing

doi:10.1530/rep-16-0089

Cited by 65 publications

(44 citation statements)

References 50 publications

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“…In physiologic settings, IL-15-mediated functional exhaustion of NK cells can be seen during endometriosis, where endometrial stromal cells secrete IL-15, which promotes immune escape via inactivation of NK cell cytolytic function (39). One could also foresee inflammatory settings, in which IL-15-mediated exhaustion of NK cells can be beneficial by capping their response.…”

Section: Discussionmentioning

confidence: 99%

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

Felices¹,

Lenvik²,

McElmurry³

et al. 2018

JCI Insight

183

150

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Section: Discussionmentioning

confidence: 99%

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

Felices¹,

Lenvik²,

McElmurry³

et al. 2018

JCI Insight

183

150

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“…[53][54][55][56][57] Due to diminished cytotoxicity, retrograde endometrial cells are prone to survive in the peritoneal cavity, which results in the development of endometriosis. Factors controlling NK cell function have not been thoroughly investigated; however, several studies have shown that IL-6, 57 IL-15, 58 and transforming growth factor-β1 59 suppress NK cell cytotoxic activity.…”

Section: Reduced Nk Cell Cytotoxic Activity In Endometriosismentioning

confidence: 99%

Involvement of immune cells in the pathogenesis of endometriosis

Izumi

Koga

Takamura

et al. 2018

J of Obstet and Gynaecol

135

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Endometriosis is characterized by the implantation and growth of endometriotic tissues outside the uterus. It is widely accepted the theory that endometriosis is caused by the implantation of endometrial tissue from retrograde menstruation; however, retrograde menstruation occurs in almost all women and other factors are required for the establishment of endometriosis, such as cell survival, cell invasion, angiogenesis, and cell growth. Immune factors in the local environment may, therefore, contribute to the formation and progression of endometriosis. Current evidence supports the involvement of immune cells in the pathogenesis of endometriosis. Peritoneal neutrophils and macrophages secrete biochemical factors that help endometriotic cell growth and invasion, and angiogenesis. Peritoneal macrophages and NK cells in endometriosis have limited capability of eliminating endometrial cells in the peritoneal cavity. An imbalance of T cell subsets leads to aberrant cytokine secretions and inflammation that results in the growth of endometriosis lesions. It is still uncertain whether these immune cells have a role in the initial cause and/or stimulate actions that enhance disease; however, in either case, modulating the actions of these cells may prevent initiation or disease progression. Further studies are needed to deepen the understanding of the pathology of endometriosis and to develop novel management approaches of benefit to women suffering from this disease.

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“…Clinically, endometrial tissues might metastasize both locally and distantly and thus inhibit endometriotic cell invasion and migration might be crucial for the management of endometriosis [32–34]. Here we showed that PCJNF could effectively inhibit the migration and invasion of EESCs in vitro, suggesting that this Chinese herbal formula could be a potential alternative option for the treatment of patients with endometriosis.…”

Section: Discussionmentioning

confidence: 66%

Ping‐Chong‐Jiang‐Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway

Liang

Zou

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Endometriosis is a common gynecological condition in childbearing age women and its therapy in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine (CHM), was shown to be clinically effective on endometriosis. Meanwhile, c-Jun N-terminal kinase (JNK) signaling pathway was involved in the therapeutic process of CHM on endometriosis. Here, we explored the effect of PCJNF on the ectopic endometrial stromal cells (EESCs) from endometriosis and test whether JNK signaling was involved. After being treated with PCJNF-containing serum obtained from Sprague Dawley rat, cell proliferation, migration, invasion, and apoptosis were evaluated in EESCs, and the total and phosphorylated JNK, ERK, and p38 proteins were detected. Our results showed that PCJNF could suppress cell proliferation, migration, and invasion and induce apoptosis in EESCs. The suppressed proliferation and increased apoptosis were dependent on JNK activation. Additionally, PCJNF caused cell cycle arrest at G2/M phase and this effect was mediated by JNK signaling, while the decreased cell migration and invasion treated by PCJNF were independent of JNK signaling. In summary, our results provided the first evidence that PCJNF could suppress cell proliferation, migration, and invasion, while increasing apoptosis in EESCs, and the suppressed proliferation and enhanced apoptosis were mediated by JNK signaling.

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IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis

Cited by 65 publications

References 50 publications

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

Involvement of immune cells in the pathogenesis of endometriosis

Ping‐Chong‐Jiang‐Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway

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