The natural compound, formononetin, extracted from <scp><i>Astragalus membranaceus</i></scp> increases adipocyte thermogenesis by modulating PPARγ activity

Nie, Tao; Zhao, Shiting; Mao, Liufeng; Yang, Yiting; Sun, Wei; Lin, Xinhua; Liu, Shuo; Li, Kuai; Sun, Yirong; Li, Peng; Zhou, Zhiguang; Lin, Shaoqiang; Hui, Xiaoyan; Xu, Aimin; Wah, Chung; Xu, Yong; Wang, Cunchuan; Dunbar, P. Rod; Wu, Donghai

doi:10.1111/bph.14139

Cited by 54 publications

(30 citation statements)

References 47 publications

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“…Identification of the possible mechanism of action of the natural product is mandatory for publication in BJP. As an example in which evaluation of an extract was followed by a detailed pharmacological analysis of the main active ingredient, a BJP paper reported that multiple distinct Chinese herbal medicine extracts increased the expression of uncoupling protein 1 in isolated adipocytes (Nie et al, 2018). The authors found that extracts from the Chinese plant Astragalus membranaceous had the highest activity and then went on to isolate and purify the components of that extract (with data from HPLC identifying the constituents).…”

Section: Papers Promoting a Phytochemical As Lead Compound For The Dementioning

confidence: 99%

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

Izzo

Teixeira

Alexander

et al. 2020

British J Pharmacology

190

181

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Section: Papers Promoting a Phytochemical As Lead Compound For The Dementioning

confidence: 99%

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

Izzo

Teixeira

Alexander

et al. 2020

British J Pharmacology

190

181

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“…Formononetin is a principal isoflavone compound extracted from Radix Astragali , which has long been used to treat cardiovascular diseases in traditional Chinese medicine. For example, formononetin has been reported to be able to reduce intracellular ROS by inhibiting mitogen activated protein kinase 8 phosphorylation ( 28 ); to inhibit breast cancer cell proliferation by regulating the phosphatidylinositol 3-kinase (PI3K)/RAC-α serine/threonine-protein kinase (AKT)/serine/threonine-protein kinase mTOR signaling pathway ( 29 ); to increase adipocyte thermogenesis by modulating peroxisome proliferator-activated receptor-γ activity ( 30 ); or to have neuroprotective effects following traumatic brain injury by increasing microRNA-155 and heme oxygenase-1 expression ( 31 ). Regarding I/R injury, formononetin has been reported to markedly reduce the infarct volume and brain water accumulation in a rat model of I/R injury via activation of the PI3K/Akt signaling pathway ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation

2018

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Myocardial infarction is a leading cause of mortality worldwide, and timely blood/oxygen reperfusion may substantially improve the outcome of infarction. However, ischemia/reperfusion (I/R) may cause severe side effects through excess reactive oxygen species generation. To develop novel methods to relieve I/R induced cell damage, the present study used a component of traditional Chinese medicine. In the present study, isolated heart tissue from aged mice and H9C2 cells with chemically-induced aging were used as experimental subjects, and it was demonstrated that formononetin was able to alleviate I/R-induced cell or tissue apoptosis. By applying formononetin to I/R-damaged tissue or cells, it was demonstrated that formononetin was able to enhance autophagy and thus alleviate I/R-induced cell damage. Furthermore, it was observed that I/R was able to inhibit lysosomal degradation processes in aged tissues or cells by impairing the lysosome acidification level, and formononetin was able to reverse this process via the re-acidification of lysosomes. In conclusion, the present study demonstrated that formononetin was able to alleviate I/R-induced cellular apoptosis in aged cells by facilitating autophagy.

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“…Both diets rich in isoflavones and the administration of daidzein were found to result in the increased expression of uncoupling protein 1 (ucp1), a thermogenic marker, in the BAT of experimental animals [77,78]. Additionally, formononetin, via direct interaction with PPARγ, was found to increase the expression of ucp1 in primary cultures of mouse adipocytes, while its administration to C57BL/6J mice was found to prevent the development of diet-induced obesity [79]. Similarly, a two-week treatment with coumestrol was found to reduce body weight and improved glucose tolerance in mice on an HFD due to the increased thermogenesis in BAT.…”

Section: Adipose Tissue Browningmentioning

confidence: 99%

Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens

2020

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In the assessment of the health risk of an obese individual, both the amount of adipose tissue and its distribution and metabolic activity are essential. In adults, the distribution of adipose tissue differs in a gender-dependent manner and is regulated by sex steroids, especially estrogens. Estrogens affect adipocyte differentiation but are also involved in the regulation of the lipid metabolism, insulin resistance, and inflammatory activity of the adipose tissue. Their deficiency results in unfavorable changes in body composition and increases the risk of metabolic complications, which can be partially reversed by hormone replacement therapy. Therefore, the idea of the supplementation of estrogen-like compounds to counteract obesity and related complications is compelling. Phytoestrogens are natural plant-derived dietary compounds that resemble human estrogens in their chemical structure and biological activity. Supplementation with phytoestrogens may confer a range of beneficial effects. However, results of studies on the influence of phytoestrogens on body composition and prevalence of obesity are inconsistent. In this review, we present data from in vitro, animal, and human studies regarding the role of phytoestrogens in adipose tissue development and function in the context of their potential application in the prevention of visceral obesity and related complications.

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The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity

Cited by 54 publications

References 47 publications

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation

Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens

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