The natural compound 2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐<scp>d</scp> glucoside protects against adriamycin‐induced nephropathy through activating the Nrf2‐Keap1 antioxidant pathway

Lin, En Yuan; Bayarsengee, Uyanga; Wang, Ching Chiung; Chiang, Yung Hsiao; Cheng, Chao

doi:10.1002/tox.22496

Cited by 32 publications

(34 citation statements)

References 37 publications

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“…Tsai et al (2011) also indicated that in addition to inhibiting renal nuclear factor-κB activation and decreasing levels of transforming growth factor-β1 in serum, antroquinonol (a major active component of Antrodia camphorate) also increased Nrf2 activation to relieve Dox-induced nephropathy. On our recent findings, the natural compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d glucoside (an active compound extracted from Polygonum multiflorum Thunb) also protected against Dox-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway (Lin et al, 2018). On the current study, silencing Nrf2 suppressed DADS-induced HO-1 mRNA and protein expressions, supporting the ability of DADS to activate the Nrf2 pathway.…”

Section: Discussionmentioning

confidence: 96%

“…Results were analyzed using the TOptical Thermocycler Real-Time PCR System (Biometra, Göttingen, Germany). Amplifications were normalized using the 2 -ΔΔCT method as pervious described (Lin et al, 2018).…”

Section: Rna Isolation Reverse Transcription (Rt) and A Quantitativmentioning

confidence: 99%

“…An experiment was conducted on 8-week-old female BALB/c mice provided by the National Laboratory Animal Center (Taipei, Taiwan). An experimental FSGS model was induced by an intravenous injection of a single dose of Dox (10 mg/kg body weight, Sigma-Aldrich) as pervious described (Lin et al, 2018). Disease onset was checked regularly using urine dipsticks (Siemens, Tokyo, Japan).…”

Section: Animal Studymentioning

confidence: 99%

“…Urine albumin excretion in the same sample was expressed as the albumin-creatine ratio (ACR; mg/mg) as pervious described (Lin et al, 2018).…”

Section: Evaluation Of Albuminuriamentioning

confidence: 99%

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The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy

Lin

Chagnaadorj

Bayarsengee³

et al. 2019

Food Sci. Technol

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The main medicinal property of garlic is mostly attributed to its organosulfur compounds, of which the oil-soluble diallyl disulfide (DADS) is the principal component of distilled garlic oil. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important cellular regulator in response to oxidative stress. This study assessed the possible protective effect of DADS on doxorubicin (Dox)-induced nephrotoxicity and its potential regulation of the Nrf2 pathway. Treatment with DADS (200 μM) induced heme oxygenase (HO)-1 and NADPH quinone oxidoreductase 1 (NQO-1) expression in a human proximal tubular cell line. The induction of HO-1 expression was suppressed in Nrf2-silenced cells. On an animal study, pretreatment with DADS relieved Dox-induced albuminuria, increased catalase activity, and reduced the urinary 8-hydroxy-2'-deoxyguanosine level. On addition, DADS ameliorated the severity of glomerulosclerosis and suppressed expressions of fibrotic and inflammatory gene expressions. Our data indicate that DADS, a major component of garlic, showed protective effects of preventing the progression of Dox-induced nephropathy through enhancing Nrf2-mediated antioxidant activity. DADS, a normal constituent of the human diet, merits investigation as a potential antioxidant daily food supplement against free radical-mediated chronic diseases.

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Section: Discussionmentioning

confidence: 96%

Section: Rna Isolation Reverse Transcription (Rt) and A Quantitativmentioning

confidence: 99%

Section: Animal Studymentioning

confidence: 99%

“…Urine albumin excretion in the same sample was expressed as the albumin-creatine ratio (ACR; mg/mg) as pervious described (Lin et al, 2018).…”

Section: Evaluation Of Albuminuriamentioning

confidence: 99%

See 2 more Smart Citations

The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy

Lin

Chagnaadorj

Bayarsengee³

et al. 2019

Food Sci. Technol

Self Cite

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“…21 The antioxidant activity that eliminates intercellular ROS has been widely studied, including the prevention of neuronal dysfunction and neural cell death. [22][23][24] Oxidative stress is an imbalance between free radical production and antioxidant defenses in CNS system. 25 Those compounds share common polyphenols residues in their chemical structure, which is critical for attenuating ROS production.…”

Section: Introductionmentioning

confidence: 99%

Attenuated glutamate induced ROS production by antioxidative compounds in neural cell lines

Xin

Cui

et al. 2019

RSC Adv.

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Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway

Molaei

Abedi

et al. 2021

Food Science & Nutrition

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Nephropathy can occur following exposure of the kidneys to oxidative stress. Oxidative stress is the result of reactive oxygen species (ROS) formation due to intracellular catabolism or exogenous toxicant exposure. Many natural products (NPs) with antioxidant properties have been used to demonstrate that oxidative damage‐induced nephrotoxicity can be ameliorated or at least reduced through stimulation of the nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling pathway. Nrf2 is a basic leucine zipper (bZip) transcription factor that regulates gene expression of the antioxidant response elements (ARE). Nrf2 is involved in the cellular antioxidant‐detoxification machinery. Nrf2 activation is a major mechanism of nephroprotective activity for these NPs, which facilitates its entry into the nucleus, primarily by inhibiting Kelch like‐ECH‐associated protein 1 (Keap1). The purpose of this article was to review the peer‐reviewed literature of NPs that have shown mitigating effects on renal disorder by stimulating Nrf2 and thereby suggesting potential new therapeutic or prophylactic strategies against kidney‐damaging xenobiotics.

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The natural compound 2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐d glucoside protects against adriamycin‐induced nephropathy through activating the Nrf2‐Keap1 antioxidant pathway

Cited by 32 publications

References 37 publications

The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy

The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy

Attenuated glutamate induced ROS production by antioxidative compounds in neural cell lines

Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway

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