Attenuated glutamate induced ROS production by antioxidative compounds in neural cell lines

Xin, Haolin; Cui, Ying; An, Zhuoling; Yang, Qian; Zou, Xuan; Yu, Ning

doi:10.1039/c9ra03848e

Cited by 17 publications

(21 citation statements)

References 49 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glutamate levels are the highest immediately after TBI, and these heightened levels are sustained for 24-48 h due to the disruption of the BBB [75]. In addition, there is some evidence that glutamate promotes ROS production [76,77].…”

Section: Excitotoxicitymentioning

confidence: 99%

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Sivandzade

Alqahtani

Cucullo

2020

IJMS

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is among the most pressing global health issues and prevalent causes of cerebrovascular and neurological disorders all over the world. In addition to the brain injury, TBI may also alter the systemic immune response. Thus, TBI patients become vulnerable to infections, have worse neurological outcomes, and exhibit a higher rate of mortality and morbidity. It is well established that brain injury leads to impairments of the blood–brain barrier (BBB) integrity and function, contributing to the loss of neural tissue and affecting the response to neuroprotective drugs. Thus, stabilization/protection of the BBB after TBI could be a promising strategy to limit neuronal inflammation, secondary brain damage, and acute neurodegeneration. Herein, we present a review highlighting the significant post-traumatic effects of TBI on the cerebrovascular system. These include the loss of BBB integrity and selective permeability, impact on BBB transport mechanisms, post-traumatic cerebral edema formation, and significant pathophysiological factors that may further exacerbate post-traumatic BBB dysfunctions. Furthermore, we discuss the post-traumatic impacts of chronic smoking, which has been recently shown to act as a premorbid condition that impairs post-TBI recovery. Indeed, understanding the underlying molecular mechanisms associated with TBI damage is essential to better understand the pathogenesis and progression of post-traumatic secondary brain injury and the development of targeted treatments to improve outcomes and speed up the recovery process. Therapies aimed at restoring/protecting the BBB may reduce the post-traumatic burden of TBI by minimizing the impairment of brain homeostasis and help to restore an optimal microenvironment to support neuronal repair.

show abstract

Section: Excitotoxicitymentioning

confidence: 99%

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Sivandzade

Alqahtani

Cucullo

2020

IJMS

View full text Add to dashboard Cite

show abstract

“…The excitotoxic neurotransmitter glutamate caused neurotoxicity by inducing the overproduction of ROS and subsequently increasing oxidative stress. 51 Previous studies showed that the extracellular glutamate content of MCAO rats reached the highest level in 1–2 hours, and began to decrease after 3 h. 52 The increase in the glutamate content was one of the earliest changes in cerebral ischemia, which was also accompanied by the decreasing amounts of glutamine. 53,54 The results of the present study showed that the serum levels of glutamate and glutamine decreased concurrently 24 h after MCAO, which was consistent with the reported results in the literature.…”

Section: Discussionmentioning

confidence: 96%

Nuciferine attenuates acute ischemic stroke in a rat model: a metabolomic approach for the mechanistic study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Glutamate is a well-known excitatory neurotransmitter engaged in neural function. Excessive buildup of intercellular glutamate leads to increased concentrations of ROS and RNS in neuronal cells [ 49 ]. Activation of the NMDA receptor by glutamate application to cultured forebrain neurons stimulates a localized ROS formation.…”

Section: Role Of Ros Generated In the Neuronal Environmentmentioning

confidence: 99%

Utility of Reactive Species Generation in Plasma Medicine for Neuronal Development

et al. 2020

View full text Add to dashboard Cite

Reactive oxygen species (ROS) are critical signaling molecules for neuronal physiology that stimulate growth and development and play vital roles in several pathways when in a balanced state, but they cause neurodegeneration when unbalanced. As ROS levels above a certain threshold cause the activation of the autophagy system, moderate levels of ROS can be used as treatment strategies. Currently, such treatments are used together with low-level laser or photodynamic therapies, photo-bio modulation, or infrared treatments, in different chronic diseases but not in the treatment of neurodegeneration. Recently, non-thermal plasma has been successfully used in biomedical applications and treatments, and beneficial effects such as differentiation, cell growth, and proliferation, stimulation of ROS based pathways have been observed. Besides the activation of a wide range of biological signaling pathways by generating ROS, plasma application can be an effective treatment in neuronal regeneration, as well as in neuronal diseases. In this review, we summarize the generation and role of ROS in neurons and provide critical insights into their potential benefits on neurons. We also discuss the underlying mechanisms of ROS on neuronal development. Regarding clinical applications, we focus on ROS-based neuronal growth and regeneration strategies and in the usage of non-thermal plasma in neuronal and CNS injury treatments.

show abstract

Attenuated glutamate induced ROS production by antioxidative compounds in neural cell lines

Abstract: Glutamate is an excitatory neurotransmitter involved in neural function.

Cited by 17 publications

References 49 publications

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Nuciferine attenuates acute ischemic stroke in a rat model: a metabolomic approach for the mechanistic study

Utility of Reactive Species Generation in Plasma Medicine for Neuronal Development

Contact Info

Product

Resources

About