The Native and Denatured States of Soluble Collagen

Influence of the mineral staggering on the elastic properties of the mineralized collagen fibril in lamellar bone

“…Hodge and Petruska (1963); Katz and Li (1973); Weiner and Traub (1986); Landis et al (1993); Rho et al (1998);Orgel et al (2001). The length of the collagen molecule is 4.4D (Boedtker and Doty, 1956) being D = 67 nm the periodic length between adjacent collagen molecules in the axial direction of the fibril. 1D period is composed by the gap or hole zone of 0.6D and the overlap zone of 0.4D (Hodge and Petruska, 1963).…”

The formation of fibrils from collagen solutions 1. The effect of experimental conditions: kinetic and electron-microscope studies

“…It appears therefore that under these conditions, at least, both sections of the overall precipitation are accelerated by increasing the temperature but that fibril width and hence E 0 are determined during the lag period. DISCUSSION The electron-microscope approach, notably in the hands of Schmitt and co-workers (Schmitt, Gross & Highberger, 1955a, b;Gross, 1956;Schmitt, 1959 has led to the concept of collagen precipitation in vitro as the aggregation ofrod-like collagen particles, whose presence in collagen solutions has been demonstrated (Boedtker & Doty, 1956;Doty & Nishihara, 1958;Hall, 1956;Hall & Doty, 1958). In spite of the wide variation of rate of formation, ultimate fibril width and extent of aggregation, all the precipitates observed in the present study consisted, almost entirely, of fibrils bearing striations with 640A periodicity.…”

“…In all cases therefore the soluble-collagen particles must have aggregated in essentially the same manner; probably in the same manner as in the formation of collagen fibrils in vivo. Boedtker & Doty (1956) presented evidence, however, for the presence of aggregated material in some of their solutions, and Mathews, Kulonen & Dorfman (1954) suggested that reversible systems of aggregates occur in collagen solutions. Some of the collagen particles present in our solutions may not therefore have been discrete collagen molecules but molecular aggregates.…”

A multiscale modelling of bone ultrastructure elastic proprieties using finite elements simulation and neural network method

“…The hierarchical combination of these components and the interconnection mechanisms between collagen molecules that provides stability and strength (cross-links), form a highly organized bone tissue. The length of the collagen molecule is approximately 4,4D [41] with D=67 nm being the periodic length between adjacent collagen molecules in the axial direction of the molecule. The period is composed by the gap or hole zone of 0,6D and the overlap zone of 0,4D [38].…”