The national — esa soyuz missions andromède, marco polo, odissea, cervantes, delta and eneide

Loon, Jack J. W. A. van; Medina, F. Javier; Stenuit, Hilde; Istasse, Eric; Heppener, Marc; Marco, Roberto de

doi:10.1007/bf02919448

Cited by 7 publications

(3 citation statements)

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“…As part of this Spanish Cervantes Scientific Mission (see ref. van Loon et al 2007 for overview), several biological experiments were performed including the GENE experiment. The experiment samples returned with the Soyuz 7 capsule in dedicated transport boxes after 11 days in real microgravity.…”

Section: Esmhintmentioning

confidence: 99%

Drosophila GENE Experiment in the Spanish Soyuz Mission to the ISS: II. Effects of the Containment Constraints

Herranz

LaVan

Medina

et al. 2008

Microgravity Sci. Technol.

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In the GENE experiment performed during an 11-day Soyuz Mission to the International Space Station (ISS), we intended to determine if microgravity affects Drosophila metamorphosis processes. Control experiments were performed including a 1g ground control parallel to the ISS flight samples and a Random Position Machine microgravity simulated control. A preliminary analysis of the results indicates that five hundred to one thousand genes change their expression profiles depending on the cut-off levels selected. Especially affected among them are the mitochondrial ones (an example with the respiratory chain is presented). We show here that there is a synergic effect of the constraints introduced to meet the requirements of the space experiment (mainly, a cold step and the use of hermetically closed Type-I containers). The cold transport step to the launch site was introduced to slow down the pupal development. The hermetically closed Type I containers were required to ensure the containment of the fixative (acetone) in the experiment. As shown here, the oxygen concentration inside the container was not optimal but fully compatible with pupal development. It is highly likely that such combined environmental effects will become a common finding in these types of studies as they become more complicated and extensive. They could open the way to understand how the gene expression patterns and the actual phenotypes can adjust to the environment. These findings indicate the importance of a vigorous ground based program in support of real microgravity experiments. Only then we can utilize the ISS in order to understand the consequences of the modified environment in outer space on living organisms.

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Section: Esmhintmentioning

confidence: 99%

Drosophila GENE Experiment in the Spanish Soyuz Mission to the ISS: II. Effects of the Containment Constraints

Herranz

LaVan

Medina

et al. 2008

Microgravity Sci. Technol.

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“…A consequence of this was the implementation by the European Space Agency (ESA) of the ‘European Soyuz Missions to the ISS’ initiative. The science performed during these Missions was reviewed in a Meeting held in Toledo, Spain, June 2006 (van Loon et al. 2007).…”

Section: Introductionmentioning

confidence: 99%

Spaceflight-related suboptimal conditions can accentuate the altered gravity response of Drosophila transcriptome

et al. 2010

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Genome-wide transcriptional profiling shows that reducing gravity levels during Drosophila metamorphosis in the International Space Station (ISS) causes important alterations in gene expression: a large set of differentially expressed genes (DEGs) are observed compared to 1g controls. However, the preparation procedures for spaceflight and the nonideal environmental conditions on board the ISS subject the organisms to additional environmental stresses that demonstrably affect gene expression. Simulated microgravity experiments performed on the ground, under ideal conditions for the flies, using the random position machine (RPM), show much more subtle effects on gene expression. However, when the ground experiments are repeated under conditions designed to reproduce the additional environmental stresses imposed by spaceflight procedures, 79% of the DEGs detected in the ISS are reproduced by the RPM experiment. Gene ontology analysis of them shows they are genes that affect respiratory activity, developmental processes and stress-related changes. Here, we analyse the effects of microgravity on gene expression in relation to the environmental stresses imposed by spaceflight. Analysis using 'gene expression dynamics inspector' (GEDI) self-organizing maps reveals a subtle response of the transcriptome to microgravity. Remarkably, hypergravity simulation induces similar response of the transcriptome, but in the opposite direction, i.e. the genes promoted under microgravity are usually suppressed under hypergravity. These results suggest that the transcriptome is finely tuned to normal gravity and that microgravity, together with environmental constraints associated with space experiments, can have profound effects on gene expression.

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“…Current and past platforms for long-duration microgravity are the Russian Photon and Bion satellites (Nikolaev and Ilyin, 1981;Ilyin, 2000), the Space Shuttle (Crippen and Young, 2011) and Soyuz missions (Van Loon et al, 2007), and the Salyut, Skylab (NASA, 1973;Michel et al, 1976), Mir, and ISS (Evans et al, 2009;Ruttley et al, 2017) space stations or the Chinese Shenzhou spacecraft (e.g., Preu and Braun, 2014;Hu and Kang, 2019), the future Chinese Space Station (e.g., Wang et al, 2019), or its predecessor facilities, such as the TongGong Spacelab (Gu et al, 2016;Li et al, 2018;Wang et al, 2018).…”

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confidence: 99%

Some Challenges in Gravity Related Research

Loon

Jack²

2020

Front. Space Technol.

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The national — esa soyuz missions andromède, marco polo, odissea, cervantes, delta and eneide

Abstract: El artículo seleccionado no se encuentra disponible por ahora a texto completo por no haber sido facilitado todavía por el investigador a cargo del archivo del mismo.

Cited by 7 publications

References 8 publications

Drosophila GENE Experiment in the Spanish Soyuz Mission to the ISS: II. Effects of the Containment Constraints

Drosophila GENE Experiment in the Spanish Soyuz Mission to the ISS: II. Effects of the Containment Constraints

Spaceflight-related suboptimal conditions can accentuate the altered gravity response of Drosophila transcriptome

Some Challenges in Gravity Related Research

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