The National Cancer Grid of India

Bhattacharyya, Tapesh; Sharma, Suresh C.; Yadav, Budhi Singh; Singh, Rajinder; Singh, Gurpreet

doi:10.4103/0971-5851.142038

Cited by 12 publications

(13 citation statements)

References 28 publications

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“…Menstrual status: In our study 56.14% were in postmenopausal group. This is in concordance with study by Bhattacharyya et al (2014) (2) (57.40%) and Raina V et al (2011) (3) (56.5%. )…”

Section: Discussionsupporting

confidence: 93%

“…Age distribution: In our study mean age is 51.42 years and median age of presentation is 50 years. Mean age of the patients in the study by Bhattacharyya et al (2014) (2) was 46 years, by Raina V et al (2011) (3) was 48 years with a range of 22 to 85 years. Median age in the study by Cance et al (2002) (4) was 44 year, by Swain et al (1987) (5) was 42 years.…”

Section: Discussionmentioning

confidence: 88%

“…TNM Stage IIIB (T4, any N, M0) & Stage IIIC (any T, N3, M0)} accounts for 30-35% of all cases of breast cancers in India. (2) Locally Advanced Breast Carcinoma (LABC) encompasses a wide spectrum of malignant breast tumors with varying presentation and remains a clinical challenge because majority of patients develop distant metastasis despite appropriate therapy. Choice of management oscillates between primary surgery with adjuvant chemo-radiotherapy and neo-adjuvant therapy followed by surgery.…”

Section: Introductionmentioning

confidence: 99%

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A Clinical Study of Locally Advanced Carcinoma of Breast

Borkar¹,

Sheikh²

2015

jebmh

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BACKGROUND: In India it is observed that most of the patients of breast cancer clinically present in late stage due to their ignorance of disease despite so much advancement in its detection and management. Locally advanced breast cancer (LABC) accounts for 30-35% of all cases of breast cancers in India. This study aims to evaluate Clinical features, Investigations, various Treatment modalities and the Clinico-pathological correlation & outcome of various treatment modalities of LABC, with special emphasis on Neo-adjuvant chemotherapy (NACT) in Indian setting. MATERIAL AND METHOD: This was a non-randomised prospective observational study. We analyzed 57 patients of LABC Stage IIIB & IIIC presenting at Government Medical College, Nagpur, Maharashtra, a tertiary care Centre from September 2012 to November 2014. RESULTS: Stage IIIB comprised 84.21% patients while remaining 15.79% were having Stage IIIC disease. Skin involvement was observed in 91.23% patients. 15.79% showed supraclavicular lymph node involvement. 32 patients received NACT (2 to 6 cycles). Out of these 32, complete clinical response (cCR) was 12.5%, partial response (cPR) was 68.75% and pathological CR (pCR) was 6.25% with Total Objective response (cCR+cPR) 81.25%. Feasibility of Breast Conserving Surgery (BCS) was observed in 12.5% patients. 25 patients underwent primary surgery followed by adjuvant chemotherapy. Modified Radical Mastectomy was performed in 89.48% patients. CONCLUSIONS: With overall clinical response of 81.25%, neoadjuvant chemotherapy is the best treatment option for patients with Locally Advanced Breast Cancer with added advantage of in vivo testing the sensitivity of chemotherapeutic agents, early management of micrometastasis and down staging the primary tumour with feasibility of BCS. Patients presenting LABC constitute a diverse group for which a variety of treatment modalities should be instituted with coordinated treatment planning among surgeons, medical oncologists and radiation oncologists.

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“…Menstrual status: In our study 56.14% were in postmenopausal group. This is in concordance with study by Bhattacharyya et al (2014) (2) (57.40%) and Raina V et al (2011) (3) (56.5%. )…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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A Clinical Study of Locally Advanced Carcinoma of Breast

Borkar¹,

Sheikh²

2015

jebmh

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“…Seventy-eight (53.1%) patients had achieved a sufficient clinical down-staging to allow BCS; these results are quite comparable with other international reports [33][34][35], but higher than that reported previously in one study from Sudan (33.3%) [13]. In fact, the literature has reported different rates of BCS after NACT ranging from 16%…”

Section: Discussionsupporting

confidence: 85%

The Response, Operability, and Type of Surgery Following Neoadjuvant Chemotherapy in Sudanese Patients with Locally Advanced Breast Cancer

Mohamed¹,

Mohamed²,

Saad³

et al. 2018

SJMS

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Background: Neoadjuvant chemotherapy (NACT) treatment has become the standard treatment for locally advanced breast cancer (LABC) in many centers worldwide. Objectives:This study evaluates the short-term response of patients with LABC to NACT and its impact on operability and the type of surgery. Patients and Methods:This is a descriptive analytical hospital-based study including 147 patients with LABC who were presented to Plastic and Reconstructive Surgery Unit at Soba University hospital (SUH), between January 2012 and December 2014, and were treated with NACT. Clinical and pathological responses to neoadjuvant chemotherapy were evaluated according to Union for International Cancer Control criteria, operability, and the type of surgery performed was also recorded. Results: All patients were females, the mean age was 43 ± 7 years, of them 53.7% were pre-menopausal, 51% presented with a breast lump, 19.7% with nipple discharge, and 19% with skin changes and ulceration. The mean initial tumor size was 7 cm ± SD. Following NACT, complete clinical response was reported in 30 patients (20.4%), partial clinical response in 92(62.6%), stable clinical response in 20 (13.6%), and five (3.4%) had progressive clinical response. Initial smaller tumors (size < 5 cm) showed a better clinical response to NACT as 76.7% of complete clinical response was achieved.Pathological complete response was achieved in 25(17%) patients, pathological partial response in 102(74.1%), and pathological stable disease in 13(8.8%). Following NACT, breast conserving surgery was performed in 78(53.1%) patients, Modified Radical Mastectomy in 64(43.5%), 25 of them had Latissimus Dorsi, and five patients were not offered surgery as they developed progressive disease during the study period. Conclusion: Following NACT, it was possible to perform surgery in more than 96% of patients with LABC.

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“…The overall DFS rates at 36, 60 and 96 months were 77.9%, 68.9% and 67.0%, respectively. 27 In a study conducted by Bhattacharyya et al, on the Outcome of neoadjuvant chemotherapy in locally advanced breast cancer: A tertiary care centre experience at a median follow-up period of 44 months 36 patients (24.3%) developed relapse of which six patients developed locoregional recurrence, while 28 (18.9%) patients developed distant metastasis 17.…”

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confidence: 99%

Role of neoadjuvant chemotherapy in downstaging locally advanced breast carcinoma, selection of surgical procedure and its outcome

2020

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Background: In clinical practice all cases of locally advanced breast carcinoma (LABC) warrant chemotherapy followed by multimodality care. Neoadjuvant chemotherapy (NACT) has been the mainstay in the management of LABC. The main aim of NACT is to downstage and prevent systemic micrometastasis early.Methods: This was a prospective study conducted on 36 diagnosed cases of stage III locally advanced breast cancer coming to the Dept. of Surgery, Dr. D. Y. Patil Medical College and hospital, Pune for a period of 2 years from 2017-2019. The effectiveness of neoadjuvant chemotherapy was assessed based on clinical, pathological and radiological response.Results: Among 36 LABC cases, maximum number of patients fell in the 41-50 years (41.6%) and presented in the Infiltrating ductal carcinoma group with a clinical stage IIIA disease. The response to NACT showed that a total of 12 patients (33.3%) showed complete clinical response and 30 patients were downstaged after neoadjuvant chemotherapy which was statistically significant. Only 4 out of the total 12 complete clinical responders went for Breast conservative surgery. Seroma formation was found to be the most common post-operative complication.Conclusions: LABC subjected to neoadjuvant chemotherapy based on taxanes/Anthracyclines show good clinical and radiological response. Patients preferred modified radical mastectomy due to the lack of awareness and low socioeconomic strata.The type of surgery did not increase the chance of recurrence in the follow up period.

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The National Cancer Grid of India

Cited by 12 publications

References 28 publications

A Clinical Study of Locally Advanced Carcinoma of Breast

A Clinical Study of Locally Advanced Carcinoma of Breast

The Response, Operability, and Type of Surgery Following Neoadjuvant Chemotherapy in Sudanese Patients with Locally Advanced Breast Cancer

Role of neoadjuvant chemotherapy in downstaging locally advanced breast carcinoma, selection of surgical procedure and its outcome

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