The nasal response to exercise and exercise induced bronchoconstriction in normal and asthmatic subjects.

Abstract

Two studies were carried out to test the hypothesis that the fall and recovery of nasal resistance after exercise in asthmatic and non-asthmatic subjects are related to the development of bronchoconstriction after exercise. In study 1 nasal resistance (posterior rhinomanometry) and specific airway resistance (sRaw) were measured before challenge and one, five, 10 and 30 minutes after four minutes of exhausting legwork exercise in nine asthmatic subjects and nine age matched healthy subjects. One minute after exercise there was a reduction in nasal resistance of49% (SD 15%) from baseline in the healthy subjects and of 66% (17%) in the asthmatic subjects. This response and the subsequent return ofnasal resistance to baseline values did not differ significantly between the two groups despite a substantial difference in the change in sRaw, an increase of 74% (45%) in the asthmatic subjects 10 minutes after exercise, and no change in the non-asthmatic subjects. In study 2, nasal and specific airway resistances were monitored according to the same measurement protocol in six subjects with increased airway reactivity. Subjects exercised on two occasions, wearing a noseclip, once while breathing cold, dry air and once while breathing warm, humid air. The fall in nasal resistance was similar under both conditions (to 47% and 39% of baseline), though sRaw rose only after cold air inhalation (to 172% of baseline). The results indicate that the nasal response to exercise is not related to bronchial obstruction in asthmatic subjects after exercise or to the temperature or humidity of the air inspired through the mouth during exercise.

Nasal resistance and flow resistive work of nasal breathing during exercise: effects of a nasal dilator strip

“…During exercise, Rn is known to fall (4,5,13,25), most likely because of sympathetic vasoconstriction in the nasal mucosa (13). This effect has been shown to persist for up to 30 min after exercise (13,18). Consequently, in the present study, we used a rest period of 30-150 min between the exercise runs.…”

Nasal and bronchial response to exercise in children with seasonal allergic rhinitis out of the pollen season

“…Stroh et al used posterior rhinomanometry to study the nasal response to exercise in healthy subjects and others with asthma or rhinitis and asthma. They concluded that the nasal response is not related to the bronchial response or the temperature and humidity of the air breathed in through the mouth during the exercise test.…”

Nasal and bronchial response to exercise in patients with asthma and rhinitis: the role of nitric oxide

“…Strohl et al (5) used posterior rhinomanometry to study the nasal response to exercise in healthy subjects and others with asthma or with rhinitis and asthma, concluding that the nasal response is not related to the bronchial response or the temperature and humidity of the air breathed in through the mouth during the exercise test.…”

“…It has been demonstrated that physical exercise is associated with a decrease in nasal resistance in healthy subjects and patients with rhinitis (1–5). It has been thought that these changes could largely be caused by a vasoconstrictive phenomenon that reduces the volume of the venous sinusoids.…”