Nasal and bronchial response to exercise in patients with asthma and rhinitis: the role of nitric oxide

Valero, Antonio; Serrano, Carlos; Valera, JL; Barberá, Ariana; Torrego, Alfonso; Mullol, Joaquim; Picado, César

doi:10.1111/j.1398-9995.2005.00835.x

Cited by 18 publications

(25 citation statements)

References 21 publications

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“…Also, other groups have not been successful in showing an evident increase in nasal NO in seasonal rhinitis, during as well as out of the pollen season [59,65]. Similar results were observed by Valero et al [66]. Although they reported an increase in nasal NO (of at least 1 h in duration) in subjects with asthma and rhinitis, no relationship between the pre-exercise and post-exercise values of nasal and exhaled NO and the bronchial and nasal responses was found.…”

Section: No In Allergic Rhinitissupporting

confidence: 79%

Nitric Oxide: A Promising Methodological Approach in Airway Diseases

Şahin

Klimek

Mullol

et al. 2011

Int Arch Allergy Immunol

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Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an important role in host defense, and is liberated in the nose and the paranasal sinuses. This review aims to highlight some aspects of the origin and function of NO in airway diseases, such as allergic rhinitis, chronic rhinosinusitis with and without nasal polyps, primary ciliary dyskinesia, and cystic fibrosis. In conclusion, NO measurement may be a promising noninvasive diagnostic marker for airway pathologies.

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Section: No In Allergic Rhinitissupporting

confidence: 79%

Nitric Oxide: A Promising Methodological Approach in Airway Diseases

Şahin

Klimek

Mullol

et al. 2011

Int Arch Allergy Immunol

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“…Eczema is often the first sign of atopy that occurs in genetically predisposed individuals [62]. Evidence is provided by a cohort study that followed asthma-free children with eczema over 4 years [63]. At the end of this period, 45% of them showed asthma-like symptoms and 35% of them were diagnosed as having asthma by a specialist.…”

Section: Discussionmentioning

confidence: 99%

Household Conditions, Eczema Symptoms and Rhinitis Symptoms: Relationship with Wheeze and Severe Wheeze in Children Living in the Polokwane Area, South Africa

Wichmann

Wolvaardt

Maritz

et al. 2008

Matern Child Health J

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Background This is the fifth study that applied the International Study of Asthma and Allergies in Childhood (ISAAC) methodology in the Southern African Development Community (SADC region). However, it is the first ISAAC study that focused on 6-to 7-year-old children living in South Africa and that also investigated the association between potential risk factors and asthma symptoms. Objective To assess the 12-month prevalence of wheeze and severe wheeze along with their potential risk factors. Setting Within a 60-km radius from the Polokwane city centre, Limpopo Province. Methods The survey was conducted during August 2004 and February 2005. Parents/guardians of 6-to 7-year-old children completed the questionnaires in English, Afrikaans or North-Sotho. However, the statistical analyses were restricted to the North-Sotho group (n = 2,437). Results The 12-month prevalence rates of wheeze and severe wheeze were 11.2% and 5.7%, respectively. The 12-month prevalence rates of eczema symptoms and rhinoconjunctivitis symptoms were 8.0% and 7.3%, respectively. Living in a rural area significantly decreased the likelihood of wheeze by 31%. Exposure to environmental tobacco smoke at home and the presence of eczema symptoms and rhinoconjunctivitis symptoms increased the likelihood of wheeze by 77%, 104% and 226%, respectively. Only the presence of rhinoconjunctivitis symptoms increased the likelihood of severe wheeze by 107%. Conclusion Wheeze appears to be an emerging public health problem in the Polokwane area. Hopefully, detailed analytical intervention studies will further explicate these results in the near future.

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“…The absolute values of nasal and oral FE NO are consistent with previous reports using the same method. 18,19,21 pH measurements in EBC The pH levels of oral EBC were significantly lower in children with AD and intermittent and moderate asthma than in HCs. In addition, pH levels were significantly lower in children with intermittent asthma than in children with AD.…”

Section: Exhaled Fe Nomentioning

confidence: 97%

“…The patients were instructed to blow up the cheeks to elevate the mouth pressure to isolate the nasal cavity from the rest of the respiratory system. 19 Before the measurements of oral and nasal FE NO , the subjects rinsed out their mouths. The units of FE NO measurements were parts per billion.…”

Section: Nitric Oxide Measurementmentioning

confidence: 99%