The nasal microbiome in patients with chronic rhinosinusitis: Analyzing the effects of atopy and bacterial functional pathways in 111 patients

Mahdavinia, Mahboobeh; Engen, Phillip A.; LoSavio, Phillip; Naqib, Ankur; Khan, Rafsa; Tobin, Mary C.; Mehta, Arpita; Kota, Raj; Preite, Nailliw Z.; Codispoti, Christopher D.; Tajudeen, Bobby A.; Schleimer, Robert P.; Green, Stefan J.; Keshavarzian, Ali; Batra, Pete S.

doi:10.1016/j.jaci.2018.01.033

Cited by 54 publications

(60 citation statements)

References 15 publications

(10 reference statements)

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“…Two recent large studies showed that the nasal microbiome of CRS patients with asthma were significantly different compared with non-asthmatic CRS cases [5,6]. Furthermore, among CRS cases, AR and atopic dermatitis were associated with significant variations in the nasal microbiome.…”

Section: Defining Endotypes Of Allergic and Inflammatory Diseasesmentioning

confidence: 99%

“…Furthermore, among CRS cases, AR and atopic dermatitis were associated with significant variations in the nasal microbiome. The reported increased relative abundance (RA) of Streptococcus along with decreased RA of Corynebacterium in atopic CRS patients [5] suggests that the imbalance between these two bacteria might be an important factor in defining an atopic endotype in CRS. Prediction of functional pathways showed that patients with AR had a higher RA of bacterial functional genes involved in lipopolysaccharide (LPS) biosynthesis compared to non-allergic patients [5].…”

Section: Defining Endotypes Of Allergic and Inflammatory Diseasesmentioning

confidence: 99%

“…The reported increased relative abundance (RA) of Streptococcus along with decreased RA of Corynebacterium in atopic CRS patients [5] suggests that the imbalance between these two bacteria might be an important factor in defining an atopic endotype in CRS. Prediction of functional pathways showed that patients with AR had a higher RA of bacterial functional genes involved in lipopolysaccharide (LPS) biosynthesis compared to non-allergic patients [5]. These results showing a link between specific genera or bacterial function, and clinical variables indicate that the nasal microbiome could be used as a tool to characterize and identify allergic endotypes of CRS.…”

Section: Defining Endotypes Of Allergic and Inflammatory Diseasesmentioning

confidence: 99%

“…While commensal microorganisms and their metabolites maintain the stability of their habitat in a symbiotic system, disturbances in the composition of these commensal resident microbes and pathogens play important roles in the initiation and potentially the progression of inflammation [1]. Current research has shown evidence for dysbiosis of the nasal microbiome in the context of allergic and inflammatory diseases of the airways such as allergic rhinitis (AR) [2][3][4], chronic rhinosinusitis (CRS) [1,5,6], and asthma [7]. We also know that the effect of the microbiome is not confined to its immediate location but rather can affect the entire host physiology.…”

mentioning

confidence: 99%

“…Use of culture-independent methods, especially analyzing the 16S ribosomal RNA of bacteria, showed evidence for a rich and diverse community of bacteria in the nose that is shifted significantly in the presence of allergic diseases [1][2][3][5][6][7][13][14][15]. With the use of current complex methods, we can not only predict the abundance of each taxa and their community structures but also predict and compare their functions.…”

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confidence: 99%

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The nasal microbiome: opening new clinical research avenues for allergic disease

Mahdavinia

2018

Expert Review of Clinical Immunology

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Section: Defining Endotypes Of Allergic and Inflammatory Diseasesmentioning

confidence: 99%

Section: Defining Endotypes Of Allergic and Inflammatory Diseasesmentioning

confidence: 99%

Section: Defining Endotypes Of Allergic and Inflammatory Diseasesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The nasal microbiome: opening new clinical research avenues for allergic disease

Mahdavinia

2018

Expert Review of Clinical Immunology

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Impact of genetic variants of GLCCI1 on operational therapy in Chinese chronic rhinosinusitis patients

Liu

Che

Fan

et al. 2018

Int Forum Allergy Rhinol

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Background: Endoscopic surgery and postoperative glucocorticoids may effectively control inflammation in patients with chronic rhinosinusitis (CRS). However, some patients who are insensitive to glucocorticoids have a poor prognosis. Studies have shown that the GLCCI1 polymorphism is related to sensitivity to glucocorticoids, but no study has been conducted in China to investigate the relationship between GLCCI1 polymorphisms and postoperative prognosis of CRS. Methods:A total of 208 CRS patients received routine functional endonasal sinus surgery and then were treated with glucocorticoids. Polymerase chain reactionrestriction fragment length polymorphism was employed to detect the rs37973G/A polymorphism of GLCCI1. The visual analogue scale (VAS) score, Lund-Kennedy score, and computed tomography (CT) Lund-Mackay score were determined 6 months a er surgery among patients with different genotypes. Moreover, the polymorphism frequency was compared among different subgroups.Results: There were no marked differences in VAS score, Lund-Kennedy score, or CT Lund-Mackay score among patients with different genotypes before surgery. In patients with the AA genotype, the changes in VAS score, Lund-Kennedy score, and CT Lund-Mackay scores were significantly higher than in patients with the GA/GG genotype (p < 0.05). However, there were no marked differences between patients with the GA genotype and those with the GG genotype (p > 0.05). Compared with patients with noneosinophilic sinusitis, the difference between the AA genotype and the GA/GG genotype was more evident in patients with eosinophilic sinusitis (p < 0.01). Conclusion:The rs37973 polymorphism is related to postoperative recovery from CRS for individual sensitivity to glucocorticoids. Furthermore, AA genotype was associated with be er treatment response in CRS. C 2018 ARS-AAOA, LLC. How to Cite thisArticle: Liu S, Che N, Fan K, et al. Impact of genetic variants of GLCCI1 on operational therapy in Chinese chronic rhinosinusitis patients. Int Forum Allergy Rhinol. 2018;8:1356-1362.C hronic rhinosinusitis (CRS) has a high prevalence, 1 and some sinusitis patients usually have concomitant nasal polyps. Recent studies indicate that chronic sinusitis

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The difference in nasal bacterial microbiome diversity between chronic rhinosinusitis patients with polyps and a control population

Gan

Yang

Tang

et al. 2019

Int Forum Allergy Rhinol

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BackgroundLittle is known regarding the role of the microbiome of the paranasal sinuses and its contribution to sinus mucosal health and disease. Consequently, we examined the microbiome of chronic rhinosinusitis patients with polyps (CRSwNP) and a control population to provide new insights into the microbiota associated with the pathogenesis of CRSwNP.MethodsFifty‐nine CRSwNP patients and 27 controls were enrolled in the study. The bacterial communities of the middle meatus were detected using 16S ribosomal RNA (rRNA)‒targeted Illumina MiSeq sequencing after microbial DNA was extracted from swabs.ResultsAlthough there was no difference in diversity between the 2 groups, richness was lower in the CRSwNP group than in the control group (p = 0.03). At the phylum level, Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes were predominant in both groups; however, the relative abundance was different, with the proportions of Actinobacteria (predominantly Corynebacterium) and Dolosigranulum being significantly higher in the control group than in the CRSwNP group.ConclusionThese results support the theory of microbial dysbiosis as the pathogenesis of CRSwNP. The reduction in the proportions of potentially protective bacteria may decrease the overall stability of the sinonasal bacterial community.

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The nasal microbiome in patients with chronic rhinosinusitis: Analyzing the effects of atopy and bacterial functional pathways in 111 patients

Cited by 54 publications

References 15 publications

The nasal microbiome: opening new clinical research avenues for allergic disease

The nasal microbiome: opening new clinical research avenues for allergic disease

Impact of genetic variants of GLCCI1 on operational therapy in Chinese chronic rhinosinusitis patients

The difference in nasal bacterial microbiome diversity between chronic rhinosinusitis patients with polyps and a control population

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