1993
DOI: 10.1111/j.1471-4159.1993.tb13431.x
|View full text |Cite
|
Sign up to set email alerts
|

The N‐Methyl‐D‐Aspartate Antagonist MK‐801 Fails to Protect Dopaminergic Neurons from 1‐Methyl‐4‐ Phenylpyridinium Toxicity In Vitro

Abstract: Recent reports suggest that NMDA receptor antagonists when administered in vivo can protect dopaminergic neurons from the toxic actions of MPP+. In the present study the possible neuro-protective effects against MPP+ toxicity of the noncompetitive NMDA receptor antagonist MK-801 was studied in primary cultures of fetal rat mesencephalic dopamine neurons. MK-801 failed to protect dopaminergic neurons from MPP+ toxicity at concentrations that completely block NMDA-induced toxicity of these same neurons. In contr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
11
0

Year Published

1994
1994
2014
2014

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 31 publications
(13 citation statements)
references
References 16 publications
(13 reference statements)
2
11
0
Order By: Relevance
“…2). Because CGNs express NMDA receptors and the neurotoxic effects of MPP ϩ could be mediated by an interaction with these glutamate receptors, we decided to test the effects of MK801, a selective NMDA receptor antagonist in our experimental conditions (Finiels-Marlier et al, 1993). Our results indicate that this selective compound did not prevent MPP ϩ -induced DNA fragmentation in CGNs (Fig.…”
Section: Role Of Cysteine Proteases 3-ma and Mk-801 In Mpp ؉ -Inducementioning
confidence: 80%
“…2). Because CGNs express NMDA receptors and the neurotoxic effects of MPP ϩ could be mediated by an interaction with these glutamate receptors, we decided to test the effects of MK801, a selective NMDA receptor antagonist in our experimental conditions (Finiels-Marlier et al, 1993). Our results indicate that this selective compound did not prevent MPP ϩ -induced DNA fragmentation in CGNs (Fig.…”
Section: Role Of Cysteine Proteases 3-ma and Mk-801 In Mpp ؉ -Inducementioning
confidence: 80%
“…NMDA receptor involvement has been reported to contribute to dopaminergic cell death in brain slices and mesencephalic cultures derived from rat after administration of metabolic inhibitors, including MPP ϩ , in some studies (Zeevalk et al, 1995;McNaught and Jenner, 1999;Bywood and Johnson, 2003) but not in others (Michel and Agid, 1992;Finiels-Marlier et al, 1993;Sawada et al, 1996). As species differences could not account for the respective changes, we reasoned that differences in experimental preparations might underlie these disparate findings.…”
Section: Discussionmentioning
confidence: 84%
“…However, the noncompetitive NMDA receptor antagonist, MK-801, failed to protect rats against MPP + and mice against MPTP neurotoxicity (15)(16)(17). The observed neuroprotective effect of ketamine may also be mediated by its dopamine D 2 receptor agonist action, as is the case for other agonists such as pramipexole reported to be neuroprotective against MPTP and 6-OHDA lesions (18).…”
Section: Discussionmentioning
confidence: 99%