The myxovirus resistance A (MxA) gene −88G&gt;T single nucleotide polymorphism is associated with prostate cancer

Glymph, Shanora; Mandal, S. K.; Knowell, Ashley Evans; Abebe, Fisseha; Chaudhary, Jaideep

doi:10.1016/j.meegid.2013.02.010

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…Alternatively, the overall low expression of MxA in prostate cancer could possibly be due to the polymorphism in the proximal promoter region of MxA. Our previous study established an association of MxA with prostate cancer risk, specifically the genotype with low promoter activity (25) which results in reduced expression of MxA. Alternatively, MxA gene could be deleted in prostate cancer as a consequence of TMPRSS2-ERG fusion in aggressive and invasive prostate cancer (8).…”

Section: Discussionmentioning

confidence: 99%

Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis

et al. 2014

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Background The interferon inducible Myxovirus (influenza virus) resistance A (MxA) is considered as a key mediator of the interferon -induced antiviral response. Mx proteins contain the typical GTP-binding motif and show significant homology to dynamin family of GTPases. Strong interaction of MxA with tubulin suggests that Mx proteins could be involved in mitosis. Studies have shown that MxA inhibit tumor motility/metastasis and virus induced apoptosis. However the clear association between MxA expression and cancer remains unknown. Meta-analysis suggested that MxA expression was inversely correlated with prostate cancer (PCa). In this study we demonstrate the expression MxA in PCa and its functional significance on the cancer phenotype. Methods The expression of MxA protein in prostate cancer was examined by immuno-histochemistry. MxA was knocked down (shMxA) or over-expressed (pMxA) in DU145 or LNCaP PCa cell lines respectively. These cell lines were used to study proliferation, apoptosis, invasion, migration and anchorage independent growth. Co-localization of MxA with tubulin was performed by immuno-cytochemistry following Docetaxel treatment. Results The expression of MxA protein was significantly decreased in PCa as compared to the normal tissues. DU145 cells lacking MxA (DU145+chMxA) showed significant increase in proliferation, associated with decreased expression of CDKN1A and B. Increased migration, anchorage independent growth in DU145+shMxA cells was associated with increased MMP13 expression. Tubulin organization was also dependent on MxA expression. Tubulin polymerizing agents such as Docetaxel was less effective in promoting apoptosis in cells lacking MxA due to altered tubulin organization. Gain of MxA expression in LNCaP cells (LNCaP+pMxA) resulted in cell cycle arrest that was associated with increased expression of CDKN1A. MxA expression was also down-regulated by dihydrotestosterone in LNCaP cells. Conclusions MxA expression is inversely correlated with prostate cancer. Down-regulation of MxA in LNCaP cells by DHT suggests that MxA could play a significant role in disease progression. Loss of MxA expression results in increased metastasis and decreased sensitivity to Docetaxel suggesting that MxA expression could determine the outcome of chemo-therapeutic treatment. Additional studies will be required to fully establish the cross-talk between androgen receptor-IFN pathway in regulating MxA expression in the normal prostate and prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis

et al. 2014

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“…acknowledged to be involved in intracellular vesicle tra cking and organelle homeostasis, which chie y participates in the cellular antiviral response against a wide range of RNA viruses, including in uenza viruses and members of the bunyavirus family [51]. It is an interferon stimulated antiviral protein that is required for a complete antiviral response [52]. Preceding study found that down-regulation of MxA in LNCaP cells by dihydrotestosterone suggests that MxA appears to be meaningfully associated with cell cycle and further cancer development while the loss of MxA expression leads to increased metastasis and decreased sensitivity to Docetaxel, which shows that MxA expression could regulate the outcome of chemotherapy [53,54].…”

Section: Discussionmentioning

confidence: 99%

A Novel Analysis of the Differentiated Expression of Long Noncoding RNAs Profiles in Human Prostate Cancer

Sun

et al. 2020

Preprint

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Background: Long noncoding RNAs (lncRNAs) have crucial roles in cancer biology. Increasing numbers of evidences have indicated that lncRNAs play an important role in the pathogenesis, invasion, and metastasis in almost all kinds of cancers. But, compared with the large amounts of patients, there is rare reports that showed the differential expression of lncRNAs in prostate cancer. Methods: In this study, lncRNA expression profiles were screened in PCa, by using 5 pairs of clinical specimens in PCa and matched non-PCa tissues with lncRNA chip. To affirm further clinical value, we extended the samples consisting of another 5 tumor specimens and 7 para-cancerous/benign contrasts by qRT-PCR in top 10 up-regulated and down-regulated lncRNAs. Results: A total of 817 lncRNAs were differentially expressed between PCa tumor and para-cancerous tissues (Fold Change ≥2.0, p < 0.05): 422 were upregulated, whereas 395 were downregulated in PCa tissues. Gene ontology and KEGG pathway analyses showed that many lncRNAs were implicated in carcinogenesis. Among differentially expressed lncRNAs, lnc-MYL2-4:1 (FC = 0.00141, p = 0.01909) and NR_125857 (FC = 59.27658, p = 0.00128) had the highest magnitude of change. The subsequent qPCR confirmed the expression of NR_125857 accorded with the clinical samples.Conclusions: Our study detected a relatively novel complicated map of lncRNAs in PCa, which may have the potential to investigate for diagnosis, treatment and follow-up in PCa. Our study revealed the expression of NR_125857 in human PCa tissues was most up-regulated. Further study of these meaningful candidates are need to research deep mechanisms.

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“…When IL-1β increases in the serum of HCV patients, consequently, the response to IFN-based therapy significantly decreases (66 …”

Section: Il-1βmentioning

confidence: 99%

“…These SNPs have a major role on expression level of IL-10 gene. Therefore, lowering IL-10 expression drives immune system to Th1 type, which results in high-sustained viral clearance (66,71). Most patients with low expression of IL10 are at high risk of rejection in liver transplantation whereas a polymorphism named RA-rs9610 A/G which lowers IL-10 expression shows a significant relation to HCV outcome (74).…”

Section: Il-10mentioning

confidence: 99%

Genetic Variations in Host Factors and their Critical Role on HCV Medication

et al. 2017

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Although standard treatments are nearly life-saving in hepatitis C patients, all patients equalldon't respond to such medications. To achieve an efficient therapeutic response in all patients, medications should individually alter based on genetic factor variations. Hence, having more detailed knowledge of the affective factors on the disease promotion could help us to organize an appropriate regime to treat HCV patients. In order to review recent studies on HCV-related treatments, the data was collected from the clinical and molecular studies published during the last 15 years in electronic databases such as PubMed, Google Scholar, Medline, Scopus and Web of Sciences. Thus, this literature reviews the recent clinical studies with the genetic-based aspects, especially those factors affecting the etiopathological and histological feature of hepatitis C, diagnostic genetic and viral affecting criteria as well as some effective treatment strategies.

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The myxovirus resistance A (MxA) gene −88G>T single nucleotide polymorphism is associated with prostate cancer

Cited by 4 publications

References 35 publications

Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis

Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis

A Novel Analysis of the Differentiated Expression of Long Noncoding RNAs Profiles in Human Prostate Cancer

Genetic Variations in Host Factors and their Critical Role on HCV Medication

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