MicroRNAs appear as small molecule modifiers, which improve many new findings and
mechanical illustrations for critically important biological phenomena and pathologic events. The
best-characterized non‐coding RNA family consists of about 2600 human microRNAs. Rich evidence
has revealed their crucial importance in maintaining normal development, differentiation,
growth control, aging, modulation of cell survival or apoptosis, as well as migration and metastasis
as microRNAs dysregulation leads to cancer incidence and progression. By far, microRNAs have recently
emerged as attractive targets for therapeutic intervention. The rationale for developing microRNA
therapeutics is based on the premise that aberrantly expressed microRNAs play a significant
role in the emergence of a variety of human diseases ranging from cardiovascular defects to cancer,
and that repairing these microRNA deficiencies by either antagonizing or restoring microRNA function
may yield a therapeutic benefit. Although microRNA antagonists are conceptually similar to
other inhibitory therapies, improving the performance of microRNAs by microRNA replacement or
inhibition that is a less well- described attitude. In this assay, we have condensed the last global
knowledge and concepts regarding the involvement of microRNAs in cancer emergence, which has
been achieved from the previous studies, consisting of the regulation of key cancer‐related pathways,
such as cell cycle control and the DNA damage response and the disruption of profile expression in
human cancer. Here, we have reviewed the special characteristics of microRNA replacement and inhibition
therapies and discussed explorations linked with the delivery of microRNA mimics in turmeric
cells. Besides, the achievement of biomarkers based on microRNAs in clinics is considered as
novel non-invasive biomarkers in diagnostic and prognostic assessments.