2014
DOI: 10.1590/0004-2730000003311
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Abstract: Differently from most hormones, which commonly are specialized molecules able to influence other cells, tissues and systems, thyroid hormones (TH) are pleiotropic peptides, whose primordial function is difficult to identify. The complex action of TH on human economy can be easily witnessed by examining the diverse consequences of TH excess and deficiency during development and after maturity. In particular, different manifestations in bone modeling and remodeling reflect the circumstantial consequences of thyr… Show more

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Cited by 52 publications
(51 citation statements)
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References 65 publications
(82 reference statements)
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“…Triiodothyronine (T3) plays a primordial role in the skeletal homeostasis and stimulates osteoblast differentiation and activity by complex direct actions on TH-receptors and indirect mechanisms, involving diverse growth factors and cytokines (2). T3 also stimulates osteoclast differentiation and bone resorption, but it still remains unclear whether this effect results from direct action in osteoclasts or indirectly through RANK-RANKL system (3). Thyrotoxicosis is an established risk factor for secondary osteoporosis due to increased bone turnover (4).…”
Section: Introductionmentioning
confidence: 99%
“…Triiodothyronine (T3) plays a primordial role in the skeletal homeostasis and stimulates osteoblast differentiation and activity by complex direct actions on TH-receptors and indirect mechanisms, involving diverse growth factors and cytokines (2). T3 also stimulates osteoclast differentiation and bone resorption, but it still remains unclear whether this effect results from direct action in osteoclasts or indirectly through RANK-RANKL system (3). Thyrotoxicosis is an established risk factor for secondary osteoporosis due to increased bone turnover (4).…”
Section: Introductionmentioning
confidence: 99%
“…2). Статиче-ски значимо снижается как уровень маркё-ров костной резорбции β-CTX, так и маркё-ра костеобразования -костной щелочной фосфатазы, отражая замедление процессов ремоделирования, что в конечном итоге приводит к снижению костной массы [3,9].…”
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“…Тиреоидные гормоны оказы-вают сложное влияние на обмен фосфора, увеличивая фосфатурию и одновременно повышая его почечную реабсорбцию [9]. Не случайно данные литературы относи-тельно метаболизма фосфора при гиперти-реозе противоречивы.…”
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