The Multifaceted Roles of RCC1 in Tumorigenesis

Ren, Xiaomin; Jiang, Kai; Zhang, Feng

doi:10.3389/fmolb.2020.00225

Cited by 24 publications

(27 citation statements)

References 69 publications

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“…S2 ). RCC1 is a highly conserved guanine nucleotide exchange factor (GEF) for the GTP-binding protein RAN and is involved in nucleocytoplasmic export along with regulation of the cell cycle via chromosome condensation during mitosis (Ren et al, 2020). While there are no previous publications characterizing RCC1L , its sister gene TCF1 is a known negative regulator of cold tolerance in Arabidopsis via the lignin biosynthesis pathway (Ji et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

COR27/28 Regulate the Evening Transcriptional Activity of the RVE8-LNK1/2 Circadian Complex

Sorkin

Tzeng²,

Romanowski

et al. 2022

Preprint

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The timing of many molecular and physiological processes in plants occurs at a specific time of day. These daily rhythms are driven by the circadian clock, a master timekeeper that uses daylength and temperature to maintain rhythms of approximately 24 hours in various clock-regulated phenotypes. The circadian MYB-like transcription factor REVEILLE 8 (RVE8) interacts with its transcriptional coactivators NIGHT LIGHT INDUCIBLE AND CLOCK REGULATED 1 (LNK1) and LNK2 to promote the expression of evening-phased clock genes and cold tolerance factors. While genetic approaches have commonly been used to discover new connections within the clock and between other pathways, here we use affinity purification coupled with mass spectrometry to discover time-of-day-specific protein interactors of the RVE8-LNK1/2 complex. Among the interactors of RVE8/LNK1/LNK2 were COLD REGULATED GENE 27 (COR27) and COR28, which were coprecipitated in an evening-specific manner. In addition to COR27/28, we found an enrichment of temperature-related interactors that led us to establish a novel role for LNK1/2 in temperature entrainment of the clock. We established that RVE8, LNK1, and either COR27 or COR28 form a tripartite complex in yeast and that the effect of this interaction in planta serves to antagonize transcriptional activation of RVE8 target genes through mediating RVE8 protein degradation in the evening. Together, these results illustrate how a proteomic approach identified time-of-day-specific protein interactions and a novel RVE8-LNK-COR protein complex that implicates a new regulatory mechanism for circadian and temperature signaling pathways.

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Section: Resultsmentioning

confidence: 99%

COR27/28 Regulate the Evening Transcriptional Activity of the RVE8-LNK1/2 Circadian Complex

Sorkin

Tzeng²,

Romanowski

et al. 2022

Preprint

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“…The ahnak gene functions as a tumor suppressor (Lee et al 2014) and may reduce cell proliferation during DII and DIII. Similarly, downregulated genes include cyclinB1 (ccnb1), cell division cycle protein 20 (cdc20), and regulation of chromatin condensation 1 (rcc1), all of which have functions in mitotic progression and cell proliferation and when overexpressed increase probability of tumorigenesis (Cekan et al 2016;Otto and Sicinski 2017;Ren et al 2020). This further highlights the potential for research on gene regulatory networks involved in annual killifish adaptations to inform research on pathways involved in human pathologies.…”

Section: Discussionmentioning

confidence: 99%

Deterministic shifts in molecular evolution correlate with convergence to annualism in killifishes

Thompson

Black

Huang

et al. 2021

Preprint

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The repeated evolution of novel life histories correlating with ecological variables offer opportunities to test scenarios of convergence and determinism in genetic, developmental, and metabolic features. Here we leverage the diversity of aplocheiloid killifishes, a clade of teleost fishes that contains over 750 species on three continents. Nearly half of these are annual or seasonal species that inhabit bodies of water that desiccate and are unfeasible for growth, reproduction, or survival for weeks to months at a time. We present a large-scale phylogenomic reconstruction of aplocheiloid killifish evolution using newly sequenced transcriptomes from all major clades. We show that developmental dormancy (diapause) and annualism have up to seven independent origins in Africa and America. We then measure evolutionary rates of orthologous genes and show that annual life history is correlated with higher dN/dS ratios. Many of these fast-evolving genes in annual species constitute key developmental genes and nuclear-encoded metabolic genes that control oxidative phosphorylation. Lastly, we compare these fast-evolving genes to genes associated with developmental dormancy and metabolic shifts in killifishes and other vertebrates and thereby identify molecular evolutionary signatures of repeated evolutionary transitions to extreme environments.

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“…RCC1 regulates the cell cycle and was shown to be related to DNA damage and tumor development [ 13 , 14 , 15 ]. In this study, numerous genetic analysis tools, such as GEPIA2, TIMER2 and UALCAN, were applied to analyze more than 10,000 samples retrieved from TCGA, GEO, GTEx and CPTAC datasets on the expression of RCC1 gene in 33 tumor entities.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a series of enrichment analyses was performed on the above two groups. Not surprisingly, RCC1-related and RCC1-interacted genes are mainly involved in known pathways linked to the cell cycle, DNA replication and RNA transport [ 5 , 6 , 13 , 18 ]. Notably, enrichment analysis showed that these genes were associated with the p53 signaling pathway, and there was currently no report on the potential relationship between RCC1 and this pathway.…”

Section: Discussionmentioning

confidence: 99%

Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)

Duan

Gong

et al. 2021

IJMS

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Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.

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The Multifaceted Roles of RCC1 in Tumorigenesis

Cited by 24 publications

References 69 publications

COR27/28 Regulate the Evening Transcriptional Activity of the RVE8-LNK1/2 Circadian Complex

COR27/28 Regulate the Evening Transcriptional Activity of the RVE8-LNK1/2 Circadian Complex

Deterministic shifts in molecular evolution correlate with convergence to annualism in killifishes

Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)

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