Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)

Abstract

Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.

A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3)

“…Our immunohistochemical analysis of various cancer tissues revealed glial cells and CAF as the main cellular population expressing PLOD3. CAFs are involved in regulating tumor-infiltrating immune cells, cancer initiation, progression, or metastasis [ 38 , 39 , 40 , 41 ]. These cells form one of the most necessary factors of the TME, playing a key role in the process of tumor infiltration, in promoting oncogenesis, and are associated with the immune evasion of cancer cells [ 42 , 43 , 44 , 45 ].…”

SaRCC1, a Regulator of Chromosome Condensation 1 (RCC1) Family Protein Gene from Spartina alterniflora, Negatively Regulates Salinity Stress Tolerance in Transgenic Arabidopsis

“…RCC1 family proteins were first characterized to function in the regulating cell cycle, but since then, different members of this family have been identified to have diverse functions [ 4 ]. In animals, RCC1 is critical for activating Ran and is involved in various biological processes coupled with Ran [ 4 , 5 , 6 ]. In plants, the RCC1 family proteins could be grouped into two major categories: one consisting of 6–7 RCC1 repeats similar to human RCC1, and the other composed of multiple domains, including the RCC1 repeats domain [ 16 ].…”

“…RCC1 family proteins could be directly involved in the assembly of mitotic spindles, formation of the nuclear envelope, transport of nuclear material, and regulation of cell cycle G1/S transition. Besides, numerous studies have revealed that they also play important roles in tumor biology [ 5 , 6 ]. In plants, RCC1 family proteins could act as regulating factors for mediating diverse biological processes such as the ultraviolet-B (UV-B) radiation response, abscisic acid (ABA) signaling, cold tolerance, and phenotypic plasticity [ 7 , 8 , 9 , 10 ].…”

CD96 as a Potential Diagnostic Biomarker and New Target for Skin Cutaneous Melanoma

“…e cutaneous melanoma (TCGA, Firehose Legacy) dataset included 480 pathology-reported cases and was further studied for CD96 applying cBioPortal (https://www.cbioportal.org/) [14].…”