The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Abstract

Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

“…Endoproteolytic breakdown of APP yields the A β peptide, which is 40-42 amino acids long. After combining A β with curcumin, research findings indicated that rats treated with A β show reduced oxidative stress, inflammation, and cognitive deficits [ 109 , 110 ]. Curcumin's potential to prevent A β aggregation and fibril formation has been demonstrated in vivo and in vitro experiments.…”

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

“…Since ancient times, natural remedies derived from various medicinal plants have been employed for their therapeutic characteristics [ 41 , 42 ]. Organic materials are frequently used in medication, nutritional, and food additive enterprises to make herbal medications, minerals, nutritional supplements, and ailment medications.…”

Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation

“…As an inflammatory mediator, IL-1 β directly affects the symptoms of POI (gas, defecation, nausea, vomiting, and so on). Its release depends on the number of AIM2 inflammasomes and microorganisms [ 25 ]. IL-10 is a potent anti-inflammatory mediator that reduces neutrophil infiltration, cytotoxicity [ 26 ], and inflammatory responses induced by intraoperative hemorrhage [ 27 ], regardless of sepsis-induced gastrointestinal function [ 28 ] or postoperative gastrointestinal dysfunction [ 29 ].…”